Liberals have causes that require taking money from one source and using it for another source. Conservatives generally don't like the way that impinges on their freedoms to make money and use it.
This Conservatives forever argue the merits of building the pie and letting things trickle down; while Liberals are always willing to impose a tax to achieve a pet project. If the free economy cannot support the cause, Liberals want to subsidize it.
Conservatives tend to rely on free enterprise and capitalism as if it will define what is good, worth doing and correct, as free enterprise will assign and allocate all resources "correctly" to those that earn them; and they don't want to mess with the hand of Adam Smith.
But Liberals have endless "good" ideas for the sake of betterment of those that need help, and for their ideals of a proper society, and many of them require a special handling that the conservatives reject out of hand because someone wealthy must pay for someone not wealthy to receive the liberal benefit.
There are other things that are not economic that produce issues, such as the religious inclination to fight scientific progress or the battles over free choice with abortions, but your post was not about that.
You are looking at good government as an exercise in economics of good management, but you must not forget to consider "rational" steps, eg to offer extended health care at the expense of someone paying for it that does not receive the benefit. If you are going to win in politics, you will need to identify your constituency and take sides. Unfortunately or fortunately you will need to get funding, and in the end, you must decide your sacrifices.
PS, are you talking about Montana?
Personally, I don't think Trump is a fascist nor do I think his ideas deserve the label of Nazism. Those are pejorative mischaracterizations of what he thinks and believes, IMO.
The radical islamists do have a concept of Islam that can be compared to the ideas of Hitler in the sense they think of the perfect Muslim like Hitler thought of the master race.
And, their reading of the supposed teaching of Mohammad would bring them to wipe out and free the world from anyone that does not fit their characterization of what is a true Muslim. This is the cult of terrorism as we see it in action.
Trump desires to take action against such disruptive beliefs and the people that expose them, and most of the civilized world, including most Muslims, agree with important parts of his thinking. It does not matter whether you are left wing or right wing, terrorism is not acceptable.
The questions of politics are what should we do about it. These questions present us with dilemmas that force the sacrifice of some goals to achieve others and the fight is over which goals to sacrifice.
In these regions, like you, I think I am a libertarian, but unlike you, I add the word "rational", so that I say one should hold out for the ideals and actions of "rational libertarians" and that there are some of the answers to be found in what Trump says, and some in what Obama (or Clinton) says.
Judgement and Wisdom is the ability to know which of the goals should be sacrificed and when. And those questions can almost never be answered definitively, otherwise there would be no sacrifice.
When John Lennon wrote "Imagine" he included a line about a world with no Religion. Maybe that is what we should sacrifice. I don't think anyone will ever get it completely right. And no view is going to please everyone, that is for certain.
One point made at the beginning of the article is a subtile, but important background idea. This is the age of "Big Data" meaning that, more than ever before, and by a long way, scientists and others, are developing data, sharing data and mining the shared data with sophisticated new tool. What has come out of this explosion of data is the discovery of an enormous number of protein targets that underlie disease.
Just as the new science is beginning to show real progress in delivery and triggers, Big Data has opened the floodgates of targets to consider for use of siRNA silencing.The cornucopia of new ways to apply siRNA to work on cancer and other ceases has never been greater and is growing at breakneck speed.
Since the human genome was mapped in 2000, the mapping of proteins and the discovery, analysis of the workings of the protein universe, the workhorses of all human cellular activity (see FR. ) , has exploded.
What better time for siRNA technology to come of age.It is the dawn of a new data driven attack on disease and siRNA is destined to become one of the hottest new genitic tool in a medical science that will be driven by genetics as never before.
The role of Big Data in all this should be appreciated by every investors in ARWR!!
Holden, I have a similar opinion. I expect the most likely scenario will be cash for rights, and no dilution because the have real pipeline assets to trade and BF will be interested. If with ROCHE or NVS, they may through in a few thousand shares, but nothing too dilutive, IMO.
They did let you know, but you don't understand the words. They fired him before his contract was up, so they are negotiating a severance package in return for a release. The BOD is not satisfied with his performance.They turned most Afrezza maters over to SNY, so they probably did not fire him for problems with the launch. They claimed that TS was fully staffed and would aggressively announce a series of pre clinical product candidates. Where are those announcements? That is one area of unsatisfactory performance under the CEOs responsibility. Also, he is a weak spokes person, and that could not have been helping him. There is a specific reason or trigger but this is confidential and won't be released. It probably is TS related.There are a range of possibilities, and we might know more when the new CEO is selected.
DTC has just gotten started. SNY has invested significant $$$ in Afrezza and they need more sales. Why abandon a drug that many users praise without advertising it? The ads are going to come when the insurance will support purchases. There will be a TV campaign. There are reasons that this YMB is not privy to for what has happened, and most of those guessing what is going on are simply wrong.
Short interest makes an a outstanding and tempting target. Sooner or later the events will turn and shorts will be under attack. All there needs to be is good sales for a good drug that insurance will cover. SNY holds the key to the door, and they can always drop prices to gain better coverage. What would stop them from increasing prices later after the drug gains traction? But, they are not going to start with low prices. You need to establish the high prices so you can give a "discount".
SNY has never entertained dropping Afrezza in 2016 and they have a 3 year campaign planned. This was explained on the day they discussed their plans to improve their diabetes franchise. Once the mandated studies and the FDA approves use of Afrezza for children, SNY will work on label improvements. This will be based of this early group that is trying the drug and raving about it. This is the information that will guide the label improvement studies.
With the CEO termination, it is hard to say where they are in licensing TS. But they have screened candidates and they are testing in preclinical studies. TS works with Afrezza, a drug that must be given all the time. They will have some versions of TS with drugs that are given much less frequently and where they are in gaining a license is unclear right now. But they do have a working technology and it does have potential so, this is a wild card. The comments they made that there would be a TS product announced this year and that they would have several to follow probably had a basis. I don't guarantee anything, but give it time.
Do your DD.
After Donald Trump in recent weeks suggested stepping up security measures to put further scrutiny on Muslim Americans, such as surveilling mosques, liberals and conservatives alike called his ideas fascist.
But in case those critiques didn't get the point across, some politicians and pundits are now making a more direct connection between Trump's views and Nazism.
Donald Trump: "I want surveillance of certain mosques"
For instance, New Day for America, the super PAC supporting the candidacy of Ohio's GOP Gov. John Kasich, released a web video this week featuring retired Air Force Col. Tom Moe, a former Vietnam POW. Moe is shown speaking at an event in Ohio, where he warns about the potential danger Trump's candidacy poses by paraphrasing the famous anti#$%$ remarks delivered by pastor Martin Niem�ller.
"You might not care if Donald Trump says Muslims should register with their government, because you're not one," Moe is shown saying over ominous music. "And you might not care if Donald Trump says he's going to round up all the Hispanic immigrants, because you're not one. And you might not care if Donald Trump says it's okay to rough up black protesters, because you're not one. And you might not care if Donald Trump wants to suppress journalists, because you're not one. But think about this: If he keeps going, and he actually becomes president, he might just get around to you. And you better hope there's someone left to help you."
On behalf of all the longs, I want to thank you think2 for putting out the effort and doing a great job at setting up that board. I definitely will read it and use it as a source and I am sure countless others interested in ARWR will watch developments. The real problem with ARWRs PPS has been that it is not getting a wide exposure among potential investors that will understand the science and buy, and I think your board will do its part to increase awareness, and potential demand over the long run, that is assuming ARWR continues to have great science to report about.
Eventually, the value that the market assigns will be the result of a lot of forces and factors, and I believe that your board will play a roll.
Good job at being a proactive investor.
That post was not a prediction of $150/share based on one chimp going into FC, but it is quite realistic to believe that if ARWR gets a drug approved for cHBV because it achieves 50% or better FCs, that would sell quite large into the 400 M cHBV patients, and the % of all patients that will try it will exceed those it gives a FC, so, yes, in that case, if it ever comes, ARWR will be rolling in revenue presumably and $150 might be a conservative call if we still have just 62 M shares outstanding.
But don't count your chickens before they hatch is a wise old saying, LOL.
Nice story. Everyone loves the idea of predicting the market. It was easier then, before the algos, however. I wonder if he could do it today, even with the luck of the Irish!
They are going to start rumors if they can and all sorts of stories. This could be the last we will see of these very nice buying opportunities. I am not saying the major break is coming in November, but I do think ARWR will get a one day jump in the several dollars range, just as it did on 10/14. It has taken over a year to build the base for a rebound. It would not surprise me to see some catalyst give ARWR the little push that shifts sentiment enough to gain some wider attention and buying from the funds. Maybe the AAT data will do it.
Don't forget, it is my understanding they define FC
1. Must have no detectable sAG
2. Must be off drug 6 months with out return of sAG
Not yet meeting the time line.
I have always understood that seroconversion follows undetectable sAG within about 3 months if there is an immune response against sAG, in which case, I would look for seroconversion of sAG as the first real clue, then the 6 months of undetectable sAG.
We are approaching it, but not ready for the call, IMO.
I don't know about $150, but I sure as hell think we are shooting to cross the 200 Day MA at $6.48 and move up from there. Looking for ARWR to realize some value from the AD information that has not yet worked its way into the PPS. On AD, pre-market, ARWR traded up to $10 and them the manipulation took it down.
This time we should reach for $10.
217 Institutional Holders
111,430,045 Total Shares Held
This Institutional count has slightly increased since last quarter. Now 27%
Laura Kronen @beyouonlybetter Jul 20
Checking my blood sugar is getting boring now. It's always perfect on #Afrezza. I feel like I just won a 22 year long race with #diabetes
PS, The fact that he is being kept on under the contract does not mean he will work another day for MNKD. It stops him from working for a competitor and it keeps him from talking about things. They have him available for questions if they need to know something, but I doubt he will be coming to work or doing anything significant to advance the company. His days at MNKD are probably over.