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Tesaro, Inc. (TSRO) Message Board

favela808 7 posts  |  Last Activity: Apr 14, 2014 9:29 AM Member since: Jan 23, 2003
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  • Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy
    This study is not yet open for participant recruitment.
    Verified April 2014 by Sidney Kimmel Comprehensive Cancer Center
    Sidney Kimmel Comprehensive Cancer Center
    Information provided by (Responsible Party):
    Sidney Kimmel Comprehensive Cancer Center Identifier:
    First received: March 23, 2014
    Last updated: April 8, 2014
    Last verified: April 2014
    History of Changes
    Full Text View Tabular ViewNo Study Results PostedDisclaimerHow to Read a Study Record
    The purpose of this study is to see if Scrambler Therapy with the Calmare MC5-A machine will relieve chemotherapy induced peripheral neuropathy (CIPN).

    Scrambler Therapy is a method of pain relief given with common electrocardiography (ECG) skin electrodes. The electrodes are placed on the body in pairs, and the Scrambler Therapy machine directs electrical signals across the field to simulate non-pain information.

    Based on other studies, we think that we relieve pain with the Scrambler therapy device, but it has not been tested in a setting such as this one. This means that some of the pain relief could be due to placebo effect, or the CIPN pain going away on its own. In this study we want to compare the Scrambler Therapy with the sham therapy (the therapy that does not use the electrical signals). We hope that this study will help us determine if the Scrambler device really helps patients with CIPN.

    Cancer patients with chronic, chemotherapy-related pain of 4 or more (on a 0-10 scale) for at least 3 months may be eligible to join this study.

    Sentiment: Strong Buy

  • Competitive Technologies (NASDAQ:CTTC)‘s stock had its “neutral” rating reiterated by Zacks in a research report issued to clients and investors on Wednesday, ARN reports. They currently have a $0.50 target price on the stock. Zacks‘s price target would indicate a potential upside of 61.29% from the company’s current price.
    Zacks’ analyst wrote, “Competitive Technologies’ current main focus lies with the marketing and distribution of the FDA-cleared and CE Marked Calmare pain therapy device. While several small studies provide some support of its efficacy, lack of broad reimbursement from private and public payers has been a significant headwind in accelerating commercialization of Calmare. A new CEO was brought onboard to orchestrate a turnaround which includes the plan to run two pivotal clinical studies to support an FDA PMA submission and improved reimbursement status. A near-term initiative to spark a resurgence in revenue growth includes streamlining the process to sell to U.S. government entities. While we think the new commercialization strategy makes sense, an investment in CTI is not without meaningful risk which is factored into our investment rating. We are initiating coverage of CTI with a Neutral rating and $0.50/share price target. “
    Competitive Technologies (NASDAQ:CTTC) traded up 10.67% during mid-day trading on Wednesday, hitting $0.31. 23,150 shares of the company’s stock traded hands. Competitive Technologies has a 52 week low of $0.05 and a 52 week high of $0.48. The stock’s 50-day moving average is $0.29 and its 200-day moving average is $0.25. The company’s market cap is $5.9 million.

    Sentiment: Strong Buy

  • Reply to

    Pain Article

    by favela808 Feb 25, 2014 10:37 AM
    favela808 favela808 Feb 25, 2014 10:43 AM Flag

    At first, these new nerve impulses going through my central nervous system felt a bit like a bee sting or a strange vibration. But after a minute or two, the only thing I noticed was the pain receding. Even though my pain came back after a few hours that first day, it reminded me what having a normal, pain-free life was like, something I wouldn’t have thought possible.

    For the first time in months, I was able to sit with my legs down in a chair — not balled up close to my body to keep them from swelling painfully. When I touched my typically oversensitive skin, it also felt different. I could feel the skin and the muscles in my legs again. It felt so weird. Good weird.

    When I left the clinic after that first day of treatment, everyone in the room got hugs. I had never hugged a doctor before.

    When I got home, I was able to take a nap for the first time in weeks. I actually fell asleep in a chair while reading because I felt so good.

    I was really skeptical when I first heard about Calmare because I know things like TENS and spinal cord stimulators don’t work for me. I was really apprehensive, but I am so glad that I tried it and that is working.

    The pain that I still experience daily is different from the pain I had a week ago. I am only halfway through my treatment and it is amazing! Compared to everything else I have tried, this is working wonders. I have pain-free times every day. Each day I walked into the clinic with less and less pain and walked out pain-free.

    I have actually been able to get out of the house! I went to the mall and walked around, took my dog on a long walk, and took my family to a water park. It has been a life changer!

    I’m super excited to see where the rest of the treatment takes me. I am hopeful that this treatment may allow my husband and I to finally start planning on having another baby, which was something we never thought possible because of my CRPS.

  • Reply to

    Pain Article

    by favela808 Feb 25, 2014 10:37 AM
    favela808 favela808 Feb 25, 2014 10:40 AM Flag

    ’ve only been walking since I attended the Rehabilitation Institute of Washington’s CRPS program in Seattle in November of last year, which got me out of a wheelchair and back on my feet. That was certainly a change for the better, but my quality of life was still nowhere near what I wanted it to be. A 4-5 on the 10 pain scale had become my “tolerable normal” and what I was beginning to anticipate for the rest of my life.

    image (2)The thing about Calmare that boggles my mind is that after trying all manner of painful procedures and medicines, and waiting weeks or months to see a result — if you have the type of pain that Calmare therapy treats, you’ll know if it will be successful for you within a few minutes.

    My first day of therapy, I walked in at a 6/10, and left an hour later, eerily close to pain-free. I started feeling a change in 30 minutes.

    The pain in my legs started to creep back in after a few hours, but I’m told that is typical after one treatment.

    Patients typically go for 10 consecutive days of Calmare treatment, though each case is different. By the end of that first round of treatment, the objective is that patients be pain-free for 30-90 days. At that point a booster treatment of one or two sessions will keep you going for another 30-90 days free of pain. It’s repeatable, not something your body is going to develop a resistance to the same way it might with drugs.

    The treatment itself is nothing more than being hooked by a few electrodes up to a machine. Electrodes placed, I might add, well outside of any area affected by pain.

    I like to think that Calmare works for pain much the same way that noise-canceling headphones do for ambient noise. The Calmare machine interrupts the chronic pain signals your brain is used to receiving and replaces those distorted nerve signals with a normal, pain-free sensation.

  • Reply to

    Pain Article

    by favela808 Feb 25, 2014 10:37 AM
    favela808 favela808 Feb 25, 2014 10:38 AM Flag

    Calmare uses electricity to block pain signals without the use of drugs. Originally developed for people suffering from chemotherapy induced peripheral neuropathy, Calmare has also been found to be and effective at treating other types of neuropathic pain, including Complex Regional Pain Syndrome (CRPS), which I’ve suffered from over the last two years.

    Calmare won’t treat mechanical pain, however. Mechanical pain in my case being the collapsed arch in my foot and the sprained ankle that led to my CRPS in the first place.

    Having the pain from my CRPS gone is like listening to the sounds of the forest, after being in an office building next to jackhammers and construction all day. The volume is turned down and suddenly you’re receiving far less sensory input. You are able to notice much more subtle nuanced things that you never had the capacity, energy or space to notice before.

    I can feel sore muscles in my foot again. I can feel them because my feet hurt so much and were so hypersensitive to touch and pressure that I wasn’t able to walk normally on them for nearly two years. My leg and foot muscles atrophied so much I had to retrain myself to walk with proper form.

  • favela808 by favela808 Feb 25, 2014 10:37 AM Flag

    National Pain Report

    Life in Pain: How Calmare Therapy Helped Me

    February 24th, 2014 by Amanda Siebe, Columnist
    Living with pain every day is kind of like living next to an airport. After a while you don’t hear the jets flying overhead anymore. They’re still there, in the middle of the night and the middle of the day, unending and ceaseless, but you don’t notice every time one flies over.

    Chronic pain is much the same. After you’ve had it long enough, your body accepts that sensation as normal. You no longer expect pleasant sensations from touch. You don’t expect to be able to wear normal clothes or take a shower. You don’t expect to be able to exercise muscles in that part of your body without excruciating pain.

    Occasionally, however, something happens that makes you reconsider everything that you’ve come to expect. Something happens that gives you a new normal.

    I started Calmare therapy last week at Pain Relief of Oregon in West Linn, OR.

    Most of my pain has gone away.

  • Reply to

    Medicare News

    by favela808 Jan 15, 2014 10:52 AM
    favela808 favela808 Feb 2, 2014 12:56 AM Flag

    January 31, 2014 by Chris Walker

    Competitive Technologies wins a favorable Medicare coverage decision for its Calmare device, with labeling as a "medical necessity."

    Competitive Technologies lands Medicare coverage for pain management device
    Competitive Technologies said it secured a favorable decision concerning Medicare coverage for its Calmare pain management device.

    The Fairfield, Conn.-based medical device company develops products for wound and pain management. The Calmare is the company's flagship product, and is used to treat neurological pain.

    The Medicare decision allows for the device to be covered as a "medical necessity" in cancer-related chemotherapy treatment. The reimbursements will go to the Calmare Pain Relief Solutions, which developed the technology.

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