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Amicus Therapeutics, Inc. (FOLD) Message Board

fenix1357 57 posts  |  Last Activity: Dec 18, 2014 5:37 PM Member since: May 28, 2010
  • Reply to

    We lost

    by nymoxup Dec 16, 2014 11:33 AM
    fenix1357 fenix1357 Dec 18, 2014 5:37 PM Flag

    Wonder who is buying; interesting the last sec. filing after the phase three results announcement mentioned possible sale of securities. This has been in planning for some time. Wonder if LG is the buyer?

  • fenix1357 by fenix1357 Dec 16, 2014 10:24 AM Flag

    Sophiris Trial fails! See below.
    What would be interesting to find out is if the drug did not meet efficacy endpoints because it was not effective or because of the high placebo response. People seem to think it was the former unlike NX1207 which might give it another chance. Explains the buying since yesterday.

    Sophiris Bio Inc. (SPHS) (the “Company” or “Sophiris”), a biopharmaceutical company developing PRX302 (topsalysin) for the treatment of symptoms of benign prostatic hyperplasia (BPH, enlarged prostate) and the treatment of localized prostate cancer, today announced findings from an administrative interim analysis of efficacy in its ongoing Phase 3 “PLUS-1” trial of PRX302 as a treatment for lower urinary tract symptoms of BPH. The Independent Data Monitoring Committee (IDMC) reported that a predefined efficacy threshold following treatment was not achieved. This administrative interim analysis was conducted specifically for planning subsequent clinical trials. The ongoing “PLUS-1” study is unaffected by this recommendation, and all patients in the study will continue to be followed to enable the evaluation of the primary efficacy endpoint at 52 weeks.

  • Reply to

    Fenix1357 and strutting on the chat board

    by munkus16 Dec 12, 2014 8:19 PM
    fenix1357 fenix1357 Dec 13, 2014 9:10 AM Flag

    You are no scientist! Look at your own posts for the last ten years. they are arrogant,abusive and reek of self aggrandisement.These are not the hallmarks of a scientist, particularly of the stature you claim for yourself. You did the same thing on the ARIAD board.

    What is your motive in posting here for the last five years?

    You enjoy being tough on anonymous boards and use mutiple aliases, all the hallmarksof a coward. This says enough about you.

    Happy Holidays!

  • Reply to

    SOPHIRIS IS NO NYMOX!!!!!!

    by ricjohn2 Nov 27, 2014 1:26 PM
    fenix1357 fenix1357 Dec 12, 2014 9:16 PM Flag

    You are no scientist!
    What is your motive in posting here for the last five years.

    You enjoy being tough on anonymous boards and use mutiple aliases, all the hallmarksof being a coward. This says enough about you.

  • Reply to

    SOPHIRIS IS NO NYMOX!!!!!!

    by ricjohn2 Nov 27, 2014 1:26 PM
    fenix1357 fenix1357 Dec 12, 2014 5:34 PM Flag

    You are the one on parade strutting around for five years parading your knowledge on this board. What has your purpose been for the last five years and before that the Ariad board? No respectable pharma would allow anyone in a responsible position to prattle on these kind of message boards. There are strict rules against this kind of stuff. Lets hear who do you work for and in what position; please no more talk about being a scientist; you bring disrepute to the word.

  • Reply to

    SOPHIRIS IS NO NYMOX!!!!!!

    by ricjohn2 Nov 27, 2014 1:26 PM
    fenix1357 fenix1357 Dec 12, 2014 2:27 PM Flag

    Lets see Sophiris changed its name to hide its shameful history, did a reverse split and diluted I don't know how many times and you come and post on the NYMOX board.
    MonkeyPus has been frequenting this board for several years; he does not have the courage or money to be short; just like you; here #$%$ in the wind. Before that he was hounding the Ariad board. He reminds me of the failed phd students who keep working in my labs for years; no deep knowledge but some glib words with major psychological issues.

  • Reply to

    Recordati

    by fenix1357 Dec 9, 2014 1:05 PM
    fenix1357 fenix1357 Dec 9, 2014 1:13 PM Flag

    Dr. A wishes all NYMOX shareholders a merry Xmas from his new home in the Carribean.

  • fenix1357 by fenix1357 Dec 9, 2014 1:05 PM Flag

    Estimated Enrollment: 340
    Study Start Date: September 2013
    Estimated Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)
    I wonder how many patients have been enrolled?

    Recordati states they will announce on Feb 12 th 2015 in their annual update as to whether they are continuing with their NX1207 trial. If they discontinue and true to form we hear nothing from Dr. A I see this as trading at 5-10 cents.

  • Reply to

    Whynotnymox: Placebo vs NX-1207

    by munkus16 Nov 25, 2014 6:50 AM
    fenix1357 fenix1357 Nov 26, 2014 1:13 PM Flag

    Antibiotic was given for three days and data was not collected until 90, 180, 270 days later. IMHO this antibiotic thing is not a big deal. All injectable placebos have big effects especially as I am sure there were cognitively challenged patients ( Recruiting was hard and I am sure no attempt was made to screen out people with alzheimers or other cognitive biases.). Having an injection and then seeing blood in your urine would convince them they had the actual drug.
    Agree Recordati has been recruiting for a year and there should be enough data for an interim analyses; certainly warranted. Also needed is for Dr. A to reveal all data, this paranoia is nonsense!
    I do think there was a signal for efficacy in the data if the drug was superior to placebo at all points in time and if Recordati interim analysis is positive grounds for a redesigned study. Also need some professional statisticians to look at the data and go over how it was collected and analysed and see if there are enough grounds to throw out the outliers in the placebo group.

    Dr. A do the job or step down.

  • Reply to

    Whynotnymox: Placebo vs NX-1207

    by munkus16 Nov 25, 2014 6:50 AM
    fenix1357 fenix1357 Nov 26, 2014 10:43 AM Flag

    I believe all patients were given antibiotics for three days or doses (I am not sure) orally as all of them (including the placebo patients) received an intraprostatic injection and hence were at risk of infection. I do not think three doses of oral antibiotics would cure prostatis (it takes weeks of antibiotics). Remember FDA approved the protocol.

  • Reply to

    sell or hold?

    by brokenrecordat895 Nov 22, 2014 9:16 PM
    fenix1357 fenix1357 Nov 25, 2014 1:53 PM Flag

    There are positives and negatives to holding.
    The positives are their financing agreement is holding so money is not a problem and so no reverse splits and dilution. The selling also seems to have abated and this seems to be the bottom price.
    Other positives are that the BPH trial in Europe is still going on and looks it will be completed. Since the drug was effective but failed to show statistical significance against the placebo and this placebo is different (not as powerful as historically injectable placebos are more powerful), there is a fair chance this study will be positive. Based on this study if positive they can hope to get EU approval and also possibly sell it in Asia/Africa and USSR. Also they can elect to do a small trial in US with run in to minimize the placebo effect (if they have the financing). This trial will have small numbers and hopefully only be for six months as the drug can get approved on a six month study .
    Another positive is the cancer indication. Its hard to be sure because they do not release any topline data but if they proceed with another trial for this or get some collaboration it will be an indication (hopefully ) that the numbers were meaningful in the first trial. I suspect LG will also demand more accountability after this current fiasco.

    The negatives are Dr. A and Dr. A and Dr.A. He has not conducted himself as a proper CEO. Just a shell shocking announcement with no further conference calls to explain further measures the company is taking to boost shareholder value. His paranoia and secrecy with no release of details is harming the company.

    There, you have my two bits :)

  • Reply to

    NX-1207 and BPH vs PC.......a question:

    by munkus16 Nov 21, 2014 2:03 PM
    fenix1357 fenix1357 Nov 22, 2014 9:57 PM Flag

    I meant posts not E mails, apologise for the error.

  • Reply to

    NX-1207 and BPH vs PC.......a question:

    by munkus16 Nov 21, 2014 2:03 PM
    fenix1357 fenix1357 Nov 22, 2014 9:52 PM Flag

    I was responding to why not.Your opinions dont matter to me.

  • Reply to

    NX-1207 and BPH vs PC.......a question:

    by munkus16 Nov 21, 2014 2:03 PM
    fenix1357 fenix1357 Nov 22, 2014 2:16 PM Flag

    Don't abuse him; feel sorry for him. He only gets off by taking delight in making other people miserable. An example of a person who is an abject failure at being a human being.

  • Reply to

    NX-1207 and BPH vs PC.......a question:

    by munkus16 Nov 21, 2014 2:03 PM
    fenix1357 fenix1357 Nov 22, 2014 2:12 PM Flag

    I guess you are a retired doctor and afraid to debate someone with more recent knowledge. I see you never respond to my E mails challenging your assumptions. I have already presented stats to you that 90% of the patients for watchful waiting elect to have a treatment- RT or surgery. In this case this offers a way of avoiding the morbidity (not mortality ). Kaplan Meier is not necessary.

  • Reply to

    Recordati has published a new presentation:

    by dupuismich Nov 20, 2014 5:51 PM
    fenix1357 fenix1357 Nov 20, 2014 6:34 PM Flag

    Nothing new on NX1207 unfortunately, still talks about it being in phase three trials.

  • Reply to

    Recordati

    by whynotnymox Nov 18, 2014 1:56 PM
    fenix1357 fenix1357 Nov 20, 2014 1:25 PM Flag

    Dr. Shore has had no association with NYMOX for the last few years. He is touting another co. now. See my previous post from a few months back below.

    The reason he said this was because he is now touting an alternative BPH treatment (See below) which does not involve needles.. He is a paid consultant; he endorses whatever procedure he is currently performing. I am glad he did not put down NX 1207 for any other reason. Your honesty is appreciated. Thanks.

    Click here for an article on sexual function and BPH by Neal D. Shore, MD, Myrtle Beach, South Carolina. Dr. Shore is a clinical urologist and principle investigator of the Prolieve Thermodilatation® System, who specializes in prostate disease and has performed more than 200 office-based minimally invasive treatments for the symptoms of BPH. This article is based on Dr. Shore's clinical experiences and opinions. Dr. Shore is a paid consultant of Boston Scientific.

  • Reply to

    Recordati

    by whynotnymox Nov 18, 2014 1:56 PM
    fenix1357 fenix1357 Nov 20, 2014 11:51 AM Flag

    Usually when I am long a stock I pay more attention to the posters who are short as it is a good way to question your assumptions and see if you are wrong but on thus board I have decided to put wrb, munkus and howabout on ignore. They are the same person with the same uninspiring intellect and paranoid fantasies and contribute nothing to my understanding.

    A basic statistical primer-If you toss a coin 4 times and it comes up heads all 4 times, the odds of doing that are one in sixteen or around.0625. This implies the odds that the coin is biased in some way is pretty high. In clinical trails we put significance at .05 so if the drug was higher than placebo at all 4 points there is a good possibility it works. Proven beyond doubt -no but good possibility-yes.

    As to all the paranoid fantasies its worth pointing out the person who has lost the most is Dr.A; he now owns 1/3 of a co. which is worth 18 million now and before was worth 200 million. Do the maths.

  • Reply to

    Recordati

    by whynotnymox Nov 18, 2014 1:56 PM
    fenix1357 fenix1357 Nov 18, 2014 10:54 PM Flag

    I emailed them twice (Recordati) and got a prompt response each time (unlike Nymox which still has not responded to my E mail from two weeks ago).
    They still have not received the data from NYMOX and the trial will continue until they can review the data. They have no anticipated date by which they will receive the data.

    Reading between the lines it appears the bulk of the money has been spent so they would rather continue the trial as if successful they can get EU approval based just on this trial. The chances of this trial succeeding are greater because its a single blinded trail which historically has a less placebo effect than a double blinded trail which was the case with the US trials.

    The NYMOX trials as per the conference call showed better results with the drug than placebo at all points 90,180,270 and 365 days although not statistically significant. This is good presumptive evidence of statistical significance. If you toss a coin 4 times, the chances of it coming up heads all four times in only 0.0625 a fairly low probability number. This seems to suggest the drug works and a better designed trial could succeed.

  • Reply to

    Recordati

    by whynotnymox Nov 18, 2014 1:56 PM
    fenix1357 fenix1357 Nov 18, 2014 6:36 PM Flag

    I emailed them twice (Recordati) and got a prompt response each time (unlike Nymox which still has not responded to my E mail from two weeks ago).
    They still have not received the data from NYMOX and the trial will continue until they can review the data. They have no anticipated date by which they will receive the data.

    Reading between the lines it appears the bulk of the money has been spent so they would rather continue the trial as if successful they can get EU approval based just on this trial. The chances of this trial succeeding are greater because its a single blinded trail which historically has a less placebo effect than a double blinded trail which was the case with the US trials.

    The NYMOX trials as per the conference call showed better results with the drug than placebo at all points 90,180,270 and 365 days although not statistically significant. This is good presumptive evidence of statistical significance. If you toss a coin 4 times, the chances of it coming up heads all four times in only 0.0625 a fairly low probability number. This seems to suggest the drug works and a better designed trial could succeed.

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