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Seattle Genetics Inc. Message Board

fib1_1_2_3_5 68 posts  |  Last Activity: Jan 30, 2015 12:08 PM Member since: Dec 8, 2000
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  • Reply to

    A Battle

    by tartiaboy Jan 30, 2015 10:55 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 30, 2015 12:08 PM Flag

    Looks like the opossing force was French :-)

  • Reply to

    Abbv info from the call great.

    by iyonwin1 Jan 30, 2015 9:56 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 30, 2015 12:03 PM Flag

    It was "over $3B", but to be safe $3B seams reasonable. So $150M (to ENTA) there. That does not include Japan though, which is a decent market (with higher roalties). Perhaps another $30M.

    So $180M is very reasonable for '16. Not bad.

  • Reply to

    What FDA dates are we waiting for??

    by vinman2228 Jan 24, 2015 1:11 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 29, 2015 2:23 PM Flag

    That trial finished recruiting by Dec 22 (Dec 8 at the earliest). The trial runs 4 weeks. So give them 2 weeks of slop and a few weeks to scrub and unblind. Looks like March is a good bet, maybe late Feb at the best.

    Also have:

    Chirotic: Oct '15
    Chirotic with portal hypertension: Jul '15

  • Reply to

    25 states worth of Medicaid goes with Vpak

    by fib1_1_2_3_5 Jan 28, 2015 5:54 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 29, 2015 10:31 AM Flag

    Damit, why do you have to spoil my hopes :-)

    I am puzzled why a buying consortium would act individually, but it is the government so who knows.

  • Reply to

    Short interest

    by onemodolar Jan 17, 2015 12:53 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 29, 2015 9:24 AM Flag

    It would not at all suprise me to find out that a substantial portion of the short was now a hedge against to be tendered shares.

    E.G., own 1000s long at $47. Plan to tender for $50, but expect to only get 75% accepted. Therefor one could short 250s against the tendered box to lock in a profit of $3X750. Once the tendor is gone the 250 short is covered by the unaccepted long shares,

    Illegal, but I doubt the SEC would bother wth it.

  • Reply to

    25 states worth of Medicaid goes with Vpak

    by fib1_1_2_3_5 Jan 28, 2015 5:54 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 28, 2015 6:09 PM Flag

    And some quick napkin numbers would make this about a $300M/y deal. This is the 3rd large deal, with a hell of a lot of the pool still unclaimed.

  • dss.moDOTgov/press/150126-missouri-designates-new-hepatitis-c-drug-for-medicaid-patientsDOThtm

    Not too shabby.

    Missouri, as part of 25-state consortium, designates new Hepatitis C drug for Medicaid patients; reaches agreement that will save taxpayers millions of dollars in Fiscal Year 2016
    Viekira to replace Sovaldi as preferred treatment option; pharmaceutical maker to pay rebate to the state
    JEFFERSON CITY, MO – The State of Missouri, as part of a 25-state purchasing consortium that includes Texas, Michigan, and Wisconsin, entered into an agreement on Jan. 22, 2015 to begin using Viekira for Medicaid patients with Hepatitis C who meet certain medical criteria. Viekira was recently approved by the FDA on Dec. 19, 2014.
    Under the agreement reached late last week, the company that makes Viekira, AbbVie, has agreed to provide a rebate to states participating in the consortium. For Missouri, it is estimated that switching to Viekira will reduce overall costs of treating Hepatitis C patients by 30 to 40 percent and result in savings of $4.2 million in Fiscal Year 2016.
    Federal law requires states to make this treatment available to Hepatitis C patients who meet certain medical criteria. Effective immediately, Viekira replaces the drug Sovaldi as the preferred treatment option for Hepatitis C patients enrolled in Missouri’s Medicaid program who meet these criteria.
    Missouri Medicaid patients who have been approved for Sovaldi as of Jan. 1, but have not yet started treatment, will now be prescribed Viekira. Patients who have already begun treatment with Sovaldi will continue to use Sovaldi for the remainder of their treatment. Sovaldi will also continue to be approved for patients for whom Viekira is not an effective substitute, which is estimated to be about 15 to 20 percent of Hepatitis C patients.
    For an able bodied adult in a family of four to be eligible for Medicaid in Missouri, the family must earn less than 19 percent of the federal poverty level, or $4,532 a ye

  • fib1_1_2_3_5 fib1_1_2_3_5 Jan 26, 2015 10:01 AM Flag

    No dilution likely for over a year. They have a decent pile of cash thanks to NVS returning MEK-162. The P3s for Selumetnib are all on AZN, and the P3s for 162 and 818 are almost all on NVS.

    The biggest dilution fear had been that they would push the 2 blood cancer drugs to hard. But this seams unlikely now that they have several shots on goal w/o them.

    Of course the present PPS is a lot higher than 2 weeks ago. But that is another story.

  • Reply to


    by bottomfeeder001 Jan 26, 2015 7:20 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 26, 2015 7:25 AM Flag

    Yes. Failure would to do would put it in default and they would owe the fulee $25 (more or less) face value.

  • Reply to

    Could not hold 7 not a good sign

    by worrywartzz Jan 23, 2015 1:17 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 23, 2015 3:16 PM Flag

    Given the huge pop, the ability to hold anywhere near $7 surprised me. I expected a drop back to the mid-low 6's.

    So I see a very strong chart.

  • Reply to

    1 indication not impressive

    by anton11267 Jan 23, 2015 2:37 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 23, 2015 3:03 PM Flag

    EDIT: I meant benimetinib as the other MEK).

  • Reply to

    1 indication not impressive

    by anton11267 Jan 23, 2015 2:37 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 23, 2015 3:01 PM Flag

    1 indication?

    The new drug is primarily melanoma, true.

    The 2 MEKs (selumetnib with AstraZ and binitumab ) are in about 60 trials across many indications. And 6 P3 trials are in progress.

    They also have several other candidates that are in P2 for various indications.

    It is OK to be ignorant, but it is stupid to give advice w/o trying to learn how ignorant you are.

  • Reply to

    new agreement

    by max40 Jan 21, 2015 6:37 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 21, 2015 8:01 AM Flag

    Correction, looks like they will be looking at the IRAK4 agent in lymphomas.

    Aurgene's pattent and some other papers indicated anti autoimmune as the purpose, but there is some comonality here. Rituxan for example is used in both settings.

  • Reply to

    new agreement

    by max40 Jan 21, 2015 6:37 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 21, 2015 7:38 AM Flag

    I am real skeptical of the PDL-1 agent from a practical perspective. They will be chasing several other VERY well funded outfits that have a clear first mover advantage. So this will not have to be just a little better than existing agents, it will have to be a lot better. And it will still be expensive to develope.

    The IRAK4 agent seams more a candidate for CRIS. It is an anti autoimmune disiese (and similar) drug candidate. As a novel agent (I have not seen anything else in this space) it is an easier (and cheaper) path. Also, I like getting out of the oncology space, too corwded. The risk of failure is high though.

    It will of course a couple years before we start getting any decent reads.

  • Reply to

    how is FMI effected by currency change

    by the_green_tara Jan 15, 2015 4:40 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 3:18 PM Flag

    Technically true. But they have 31% of existing shares contractually committed to tendering if needed, and 5M new shares.

    That leaves so few shares needed from elsewhere that this is a done deal.

  • Reply to

    ENTA will post a 20pe minimum x $4 shr

    by whatdiduexpect2003 Jan 16, 2015 2:24 PM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 2:41 PM Flag

    Though I believe ENTA is worth north of $60 by spring, you have to be careful about using P/E ratios on this type investment. A DCF model is MUCH more rational.

    The reason is that the vast majority of their revs are part of a single drug that will have milestones, then quickly hit peek sales, then decline (over some uncertain time frame). Even the second gen HCV agent just tweeks this a bit.

  • Reply to

    European approval granted

    by uplinvestor Jan 16, 2015 4:59 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 12:54 PM Flag

    Who cares? Nobody is pencilling in any significant revenue from outside US/EU/Japan and a few otehr western countries. Countries like India and China add zero to the value of an expensive drug.

    An Indian infringer can not sell in countries where the patent is valid.

  • Reply to

    Serious question

    by joesolomon333 Jan 16, 2015 10:36 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 12:09 PM Flag

    I will answer that for my case.

    I do not trust management for good reason. The existing drugs arecommercially marginal. And the pipeline has some ability to produce a "decent" drug, but I do not see a true blockbuster,

    All that factors into the company we look at today, and is why the stock is where it is.

    That said, I see a company that can become a decent specialty pahrama and have solid enough numbers to deserve a PPS in the teens. And not really much risk here.

  • Reply to

    Fuel hedges

    by leggio123 Jan 16, 2015 8:30 AM
    fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 11:55 AM Flag

    Refineries can be profitable regardless of the price of crude. The Trainer losses a year ago were driven by a failure in the ethanol credit market (which they must buy as they can not blend ethanol into jet fuel). That market has since normalized.

    Hedges are a modest issue. In the long run they should average out (unless one is speculating as opposed to true heding).

  • fib1_1_2_3_5 fib1_1_2_3_5 Jan 16, 2015 11:49 AM Flag

    Q4 improved both load and PRASM over '13 numbers.

    On load, the domestic numbers are much improved. On PRASM, not yet known, but I suspect domestic also was much improved (as we know international was imapired by the strong dollar).

    The month of Dec was off. But that is only a portion of the data and is comparing different travel weeks from last year.

31.16-0.340(-1.08%)Jan 30 4:00 PMEST

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