No one here can influence the price.....I am here to gain more info on science info, which I mayhave overlooked...GL all
When you guys mention FC, in theory waking up the Immune System with 90%KD, does that include Veritcal Transmission? Consider in Vertical Transmission, will that child's immune system ever know that hbv is actually "bad" or "foreign"..since it has alway been there and immune cells may think hbv is native to the host.
I listened to the CC this weekend again, I definitely think they are leaning to Multi Doses due to great data; therefore abandoning 5 mg, which most likely will be in 80% KD only.......
I don't care how ARWR does it, but 1log is a must for a homerun here....
FC will be grand slam (again no matter how they do it,,,multidoe,combo with entecavir and/or tenofovir,,,even with interferon)......
"receiving daily oral entecavir (0.5-1.0 mg/day) or daily oral tenofovir (300 mg/day) and a single IV injection of ARC-520."
why not also add entecavir 0.5mg and tenofovir 300mg combo with ARC-520...?? Combo of entecavir and tenofovir is standard treatment nowdays,,,,,
"1) They are saying NO NEED to test 5mg or higher due to what they UNDERSTAND."
What does that really mean ?,,
1) 4 mg reaches near 90% KD or
2) 3 and 4 mg has same upper bound KD (ex, 75% KD; therefore , no need for 5mg)
3) getting great result from Multi Dosing so moving away from 5mg
Oh yah,,,chimp did show 82% at 5mg,,,thx saratoga733,,,,,,the disease state may be the key to the wide range of KD...the damn thing Works,,,butttt
good post, but I would hate that being the case,,,,another scenario is 4mg can get to 1log or 4mg start to show some sign of toxicity,,,,yap just don't know,,,
Hepatologists, MD, PhD, or Scientists on this board needs to go to Arrowhead at Pasadena,CA and ask about 5mg? There must be a strong scientific reason behind it..