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Celldex Therapeutics, Inc. Message Board

frankfrazzano 866 posts  |  Last Activity: 7 hours ago Member since: Feb 9, 2008
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  • Reply to

    100% increase to 900MG kevetrin?

    by lee122oneill 8 hours ago
    frankfrazzano frankfrazzano 7 hours ago Flag

    lee they will take it to the MTD whatever that is and 450 to 900 albeit is a double or 100% increase but if the signal is still strong on the efficacy side and we can only A$$UME that it is because we hear very little reporting on CASE STUDY and treatment successes..even that last case where the Woman had cancer mets that spread to her spleen/liver?? and they DISAPPEARED but than she had an increase in her tumour marker CD-125 I think so she went off study---to me this speaks to EFFECT but maybe not as robust as can be achieved--keep in mind that in MTD trial DURABILITY of EFFECT is very important..this will lead to an evetual P-2 trial design that is fully vetted for MTD and safety....

    I mean they said NO DOSE LIMITING TOXICITY HAS BEEN SEEN AT THESE HIGHER DOSES....to me that speaks to PUSH THE DOSE HIGHER AND LETS SEE WHERE THIS THING STARTS TO SHOW TOX especially if that higher dose means improved efficacy..iows if there is a DOSE DEPENDENT EFFICACY CURVE...that Im not sure of?

    remeber they started at 10mgs per m2 a long time ago nov 2012..we have come a long way baby..this journey is just beginning lee!

    With each cohort now the 11th next we get a clearer picture...they have moved slowly and DELIBERATELY so you may be correct and the midline or 675 is chosen..its just that once you get to 675 to push 900 is 275 or 40% higher and the committee may decide to just go ALL IN SO TO SPEAK..thinking that if they see issues they can stop and go to 675 pretty quickly--the protocol calls for 12 more pats allowed on trial once they reach MTD I think??

    ...I mean every chemo eventually has a MTD and the goal is to push up to that level and than pull back...I think Dr Alex said WE ARE GOING TO PUSH OUR NOVEL DRUG AS FAR AS POSSIBLE so I say 900 is next....its not like this is a LD 50 or LD 100 trial..its not a lethal dose thing in rats..its push what Humans can tolerate...

    Fraz

  • frankfrazzano frankfrazzano Mar 27, 2015 3:18 PM Flag

    heres the email I received on it!

    Preston Robert Tisch Brain Tumor Center
    Featured Sunday on 60 Minutes
    Gromeier Polio Virus

    Researchers, physicians, and patients from the Robert Preston Tisch Brain Tumor Center at Duke will be featured on two segments on 60 Minutes this Sunday, March 29, at 7 p.m. on CBS.

    The story features an investigational therapy developed at Duke to treat aggressive brain cancer. The promising experimental treatment was given to 22 glioblastoma patients, two of whom have been declared cancer free by doctors.

    The treatment took more than 10 years of research at Duke to develop. Learn more about this promising advance by visiting the Tisch Brain Tumor Center web site, or watch this short Duke Medicine video.

  • Reply to

    I hope the WEAK HANDS are out.

    by grey3840 Mar 25, 2015 6:57 PM
    frankfrazzano frankfrazzano Mar 26, 2015 9:22 AM Flag

    they are BUYING now grey but as recent as a coupel weeks ago at 32+ they were UNLOADING...truts me..if they were not unloading than they were taking out a PUT and they have helped to push the sp down! Alos I use the IO term losely to include the HEDGIES where most of this action occurs! Like I said I buy the dips and I sell the pops....NOT ALL EVER but about 10% usually! That is how Ive attained FREE and CLEAR CLDX shares..its PLAIN and its SIMPLE!

    Fraz

  • ..they bought the ENTIRE DILUTION at $24.50 or whatever sp several million shares...the stock sp than started to head up..25 than 26 than 27 and so on..we saw the momo crowd come onto our BOARD and they raved about CLDX...all new pumpers...sp continues to climb....the INSTITUTIONS were slowly selling into the runnup...what they did not tell US is they PUT on a short position at about 30-32 in sp....all along SELLING into the final stages of the RUN UP! They booked all the spread from the Dilution sp at 24.50 all the way up to 32+ where we topped out...now the short kicks in and they will make MONEY on the PUT likely all the way down to 24 again!

    Maybe lower?

    This is disgusting but legal!

    The only thing we can do is be vigilant and stick to our Plan...I sell some at the tops and buy some more at the Bottoms....hold the CORE always!

    Fraz

    Sentiment: Strong Buy

  • Reply to

    The thing about a technical correction ....

    by mymandon Mar 25, 2015 1:27 PM
    frankfrazzano frankfrazzano Mar 25, 2015 2:56 PM Flag

    paper lo$$es are NOT real lo$$es just as PAPER GAINS atre not real gains..onlt shares TRADED and strikes struck count...I for one ADDED again today 1500 new shares!

    Fraz

  • TREASURE!

    CASH is KING once again!

    Fraz

    Sentiment: Strong Buy

  • frankfrazzano frankfrazzano Mar 25, 2015 2:00 PM Flag

    RIGHT!

    We are CASH RICH YOU IDIOT!

    BUYING WHAT OTHERS SELL!

    Fraz

  • Reply to

    Richard A. van den Broek

    by gerald_pontificus Mar 24, 2015 3:04 PM
    frankfrazzano frankfrazzano Mar 24, 2015 5:38 PM Flag

    that can ALL change in the BLINK of an EYE.....

    long RGDX and CLDX!

    Fraz

  • Reply to

    Bout time for FrankyJOFranzanno

    by badassford59 Mar 23, 2015 2:01 PM
    frankfrazzano frankfrazzano Mar 24, 2015 5:23 PM Flag

    lee my lad...I be in CTIX just not as much as when I was at the top...remember those high $4's

    I may get back there..you never know?

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 3:15 PM Flag

    rays PLEASE PUT MBB ON IGGIE..hes waste of time for Gods sake!

    cant get his FACTS straight...Bush was reading to BLACK ELEMENTARY SCHOOL KIDS, something their OWN FATHERS NEVER DO TO THEM UNFORTUNATELY.... when they broke the 9/11 news to him....

    NOT A PHOTO OP as mbb said!

    Fraz

  • Reply to

    Bout time for FrankyJOFranzanno

    by badassford59 Mar 23, 2015 2:01 PM
    frankfrazzano frankfrazzano Mar 24, 2015 2:49 PM Flag

    LOL!

    thats funny and almost TRUE bada$$ford59 my old friend!

    I made $57K actually and Im on the fence as to what to do next....

    ..maybe U can advise me since I dont know what the heck Im doing...being an old TERP and having matriculated at a REAL university at a real BUSINE$$ $CHOOL in the early 70s....and all that!

    I still have a few shs if thats what you want to know....

    I wonder if that was leebaby buying that 22,000 shares 3.22 just now?

    Hes loaded!

    Im not in lees league thats for sure!

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 1:59 PM Flag

    rays that MORON mbb would not know 9/11 if one of the towers came CRASHING DOWN and impaled his LAME #$%$!

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 1:14 PM Flag

    rays GWB put together a COALITION that was SIGNED ON BY ALL BUT 1 DEMOCRAT to GO TO WAR and many COUNTRIES joined in against IRAQ......BHO---this nutcase running our Country now DRAWS RED LINES in the Syrian SAND..creates Vaccuums in so that ISIS can become a COuntry now....tells our ENEMIES about TROOP DRAW DOWNS....and the Day we are leaving Iraq...now thats real Leadership right...leading US right into the Crapper!

    mbb is a Moron....put him on iggie..I read his LAME posts from T to T just to get a good LAUGH....

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 12:54 PM Flag

    rays BHO a MUSLIM ANARCHIST from Chicago..

    home of LOUIS FARRAKHAN--the J*W HATER--American HATER--RACE DIVIDER..enuff said?

    It all fits...right..the Reverend Wright and all his BS rabble rousing AMERICA HATER OPENLY IN CHURCH..than we had BHOs buddy the MAD BOMBER of the 60-70s....what was his name???

    Oh yeah BILL AYERS..remember?

    Must I go on and on with this stuff...oh yeah mbb is reading my posts...lets go ON and ON!

    LOL!

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 12:44 PM Flag

    BHO had his AZZZZAZAZAZAZ handed to him by NET and now he WHINES like the little sissy he is..and he PICKED his school where he supposedly matriculated,,I think he smoked a lot of dope personally and rarely went to class...PRINCETON over MARYLAND in WOMENS BB and my TERP women handed the PRINCETON women their AZZESSEZ to them....and my girls AINT NO NAPPY HEADED HOES...or was that the Rutgers Women?

    I must call Don Imus and get clarification on that!

    BHO is cry baby...worst POTUS ever in American History!

    Fraz

  • frankfrazzano by frankfrazzano Mar 24, 2015 11:25 AM Flag

    Fraz

  • 03/23/2015
    Executed

    SNY
    SANOFI SPON ADR Sell Limit:$51.33 GTC:05/22/2015 25.000 $51.36 —

    ...excuse me but is not 51.36 the H today for SNY?

    dont tell the MORON MBB...he might quibble and say I got lucky!

    LOL

    Im coming out SNY w/ profit now for those wondering?

    Fraz

  • frankfrazzano by frankfrazzano Mar 24, 2015 9:24 AM Flag

    Date Open High Low Close / Last Volume
    03/23/2015 2.19 2.19 1.87 1.93 28,113,120

    ....if 28M shares traded yesterday than that means 28M/33.291M=84% of OS traded..thats a huge turnover of float..it speaks to INSTITUTUIONS taking the loss on paper...the SI was very low so no real influence of SHORT INTERESTS means people were very CONFIDENT! That is still LIKELY to be the case imo and the BUYERS will come back but it will be 31 days or more..WASH SALE RULES APPLY!

    Keep this in mind longs if you took a loss too!

    Trades around 2.15-2.25 share average next 30 days or so and than the BUYERS will come back!

    I could be wrong but thats my bet....

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 8:54 AM Flag

    hasthegoods..I agree in theory on what you posted but could you give MORE COLOR to your thesis for those of us on the board who may not have your BIO DEPTH? Can you think of any paralel programs in other cancer meds where we see similiar early findings and than later on the TRUE DRUG BENEFIT is revealed as data matures?

    What does this suggest to CELG and Vidaza going forward iyo?

    Belinostat eventually proved benefit is all I can think of....[Belinostat is a pan-histone deacetylase (HDAC) inhibitor. According to the manufacturer, it is differentiated from other drugs in this class because it inhibits all 3 classes of the zinc-dependent HDAC enzymes.] SPPI now markets this drug but I can remember ROUGH TIMES early on.....wasnt there some sort of MARKET SELLOFF OF TOPOTARGET over Belinostat....a short play or something I seem to recollect years ago?

    SPPI never buys a cancer drug they cant get CHEAPLY!

    Thanx?

    Fraz

  • frankfrazzano frankfrazzano Mar 24, 2015 8:30 AM Flag

    hers why...

    Brims noted, "While the response rate was the primary endpoint of this study, we believe durability endpoints are the more important measure of efficacy, and this study is ongoing, with too few events for either an assessment of progression free survival or overall survival. We believe these data will be the deciding factor in continuing development for MDS, and we expect these data before YE2015. We remain confident in the potential of pracinostat in AML/MDS and are maintaining our BUY rating."

    Furthermore, "We believe duration endpoints are the better gauge of a drug's efficacy than response rate alone, and expect these data to be presented in 2015 as more events accrue. We expect MEIP to present full data from the phase 2 AML trial at EHA (Vienna, Austria, June 11-14) and mature data for the duration endpoints from the phase 2 MDS study at ASH (Orlando, FL, Dec. 5-8)."

    I agree w/ him..too many new cats coming and plenty of cash to see it through!

    should have done this TRIAL w/ ORR not CR! Fortunately its ONGOING in OS and PFS will prevail I hope over time...prelims are still too early to be meaningful!

    STRONG BUY IMO!

    Fraz

CLDX
27.17+1.21(+4.66%)Mar 27 4:00 PMEDT