Kathryn L. McCabe, Noelia J. Kunzevitzky, Brian P. Chiswell, Xin Xia, Jeffrey L. Goldberg, Robert Lanza
To generate human embryonic stem cell derived corneal endothelial cells (hESC-CECs) for transplantation in patients with corneal endothelial dystrophies.
Materials and Methods
Feeder-free hESC-CECs were generated by a directed differentiation protocol. hESC-CECs were characterized by morphology, expression of corneal endothelial markers, and microarray analysis of gene expression.
hESC-CECs were nearly identical morphologically to primary human corneal endothelial cells, expressed Zona Occludens 1 (ZO-1) and Na+/K+ATPaseα1 (ATPA1) on the apical surface in monolayer culture, and produced the key proteins of Descemet’s membrane, Collagen VIIIα1 and VIIIα2 (COL8A1 and 8A2). Quantitative PCR analysis revealed expression of all corneal endothelial pump transcripts. hESC-CECs were 96% similar to primary human adult CECs by microarray analysis.
hESC-CECs are morphologically similar, express corneal endothelial cell markers and express a nearly identical complement of genes compared to human adult corneal endothelial cells. hESC-CECs may be a suitable alternative to donor-derived corneal endothelium.
Received: September 4, 2015; Accepted: November 30, 2015; Published: December 21, 2015
Funding: The study was funded by Ocata Therapeutics and associated collaborators (listed as authors). All had a role in the above. The funders had a role in study design, data collection and analysis, decision to publish, and preparation of the manuscript.
"The Gabelli merger arbitrage portfolio team leverages the research capabilities of our more than thirty analysts to evaluate deal risk resulting from antitrust, regulatory, financing and timing, as well as to determine synergies, strategic considerations and alternative interested buyers."
Why are you working beares time slot? You Ihubfellas running scared and keep_ing the "recorder" safe since the Feds grabbed "the lawyer" yesterday?
The Adviser seeks to limit excessive risk of capital loss by utilizing various investment strategies including investing in value-oriented common stocks, i.e., common stocks that trade at a significant discount to the Adviser's assessment of their 'private market value' - the value informed investors would be willing to pay to acquire the entire company...
GABELLI ABC FUND
12/17/15 251,226 8.4950
12/16/15 184,172 8.4950
12/15/15 604,602 8.4940
11/13/15 316,000 8.4750
11/10/15 44,000 8.4120
Washington D.C., Jan. 14, 2016 — The Securities and Exchange Commission today announced that Goldman, Sachs & Co. has agreed to pay $15 million to settle charges that its securities lending practices violated federal regulations.
According to the SEC’s order instituting a settled administrative proceeding, broker-dealers such as Goldman Sachs are regularly asked by customers to locate stock for short selling. Granting a “locate” represents that a firm has borrowed, arranged to borrow, or reasonably believes it could borrow the security to settle the short sale. The SEC finds that Goldman Sachs violated Regulation SHO by improperly providing locates to customers where it had not performed an adequate review of the securities to be located. Such locates were inaccurately recorded in the firm’s locate log that must reflect the basis upon which Goldman Sachs has given out locates.
“The requirement that firms locate securities before effecting short sales is an important safeguard against illegal short selling,” said Andrew J. Ceresney, Director of the SEC’s Enforcement Division. “Goldman Sachs failed to meet its obligations by allowing customers to engage in short selling without determining whether the securities could reasonably be borrowed at settlement.”
The SEC’s order finds that when SEC examiners questioned the firm’s securities lending practices during an examination in 2013, Goldman Sachs provided incomplete and unclear responses that adversely affected and unnecessarily prolonged the examination.
“SEC exams ensure that market participants are following the rules, so there will be consequences, including in the determination of remedies, when a registrant fails to provide complete and clear responses to examination staff,” said Andrew M. Calamari, Director of the SEC’s New York Regional Office.
According to the SEC’s order, Goldman Sachs employees who were members of the firm’s Securities Lending Demand Team routinely processed customer locate requests by relying on a function of the Goldman Sachs order management system known as “fill from autolocate,” which was accessed via the “F3” key. This function enabled employees to cause the system to grant locate requests based on the amount of reliable start-of-day inventory reported to Goldman Sachs by large financial institutions, even though its automated system had already deemed this inventory to be depleted based on locate requests processed earlier in the day.
The SEC’s order finds that when Goldman Sachs employees used this function to grant locate requests, they relied on their general belief that the automated model was conservative and the granting of additional locates would not result in failures to deliver when the securities became due for settlement. In doing so, the Goldman Sachs employees did not check alternative sources of inventory or perform an adequate review of the securities to be located.
The SEC’s order also finds that Goldman Sachs’s documentation of its compliance with Regulation SHO was inaccurate as it failed to sufficiently differentiate between the locates filled by its automated model and those filled by the Demand Team using the “fill from autolocate” function. In both cases, the locate log simply mentioned the term “autolocate” to refer to the start-of-day inventory utilized by the firm’s automated model as the source of securities underlying the grant of a locate.
The SEC’s order finds that Goldman Sachs violated Rule 203(b)(1) of Regulation SHO and Section 17(a) of the Securities Exchange Act. Without admitting or denying the findings, Goldman Sachs consented to the order and agreed to pay the $15 million penalty. The order censures Goldman Sachs and requires the firm to cease and desist from committing or causing any violations and any future violations of Rule 203(b)(1) of Regulation SHO and Section 17(a) of the Exchange Act relating to short sale locate records.
To qualify for an award under the Whistleblower Program, you must submit information regarding possible securities law violations to the Commission in one of the following ways:
Online through the Commission’s Tip, Complaint or Referral Portal; or
By mailing or faxing a Form TCR to:
SEC Office of the Whistleblower
100 F Street NE
Mail Stop 5553
Washington, DC 20549
Fax: (703) 813-9322
Washington D.C., Jan. 15, 2016 — The Securities and Exchange Commission today announced a whistleblower award of more than $700,000 to a company outsider who conducted a detailed analysis that led to a successful SEC enforcement action.
“The voluntary submission of high-quality analysis by industry experts can be every bit as valuable as first-hand knowledge of wrongdoing by company insiders,” said Andrew Ceresney, Director of the SEC’s Enforcement Division. “We will continue to leverage all forms of information and analysis we receive from whistleblowers to help better detect and prosecute federal securities law violations.”
Sean X. McKessy, Chief of the SEC’s Office of the Whistleblower, added, “This award demonstrates the Commission’s commitment to awarding those who voluntarily provide independent analysis as well as independent knowledge of securities law violations to the agency. We welcome analytical information from those with in-depth market knowledge and experience that may provide the springboard for an investigation.”
The SEC’s whistleblower program has paid more than $55 million to 23 whistleblowers since the program’s inception in 2011. Whistleblowers who voluntarily provide the SEC with unique and useful information that leads to a successful enforcement action may be eligible for an award. Whistleblower awards can range from 10 percent to 30 percent of the money collected when the monetary sanctions exceed $1 million. All payments are made out of an investor protection fund established by Congress that is financed entirely through monetary sanctions paid to the SEC by securities law violators. No money is taken or withheld from harmed investors to pay whistleblower awards.
By law, the SEC protects the confidentiality of whistleblowers and does not disclose information that might directly or indirectly reveal a whistleblower’s identity.
Matthew Brown, operator of the penny stock website Investors Hub, has been sentenced to four years in jail for securities fraud and money laundering. He received the sentence on Wednesday, May 18, in an appearance before Delaware Judge Sue Robinson. His arrest followed an investigation into the manipulation of four pink sheets listings, including Ontario-based Playstar Corp.
Mr. Brown, 27, had faced a maximum of 50 years in jail and fines of over $1-million. (All figures are in U.S. dollars.) He accepted a plea agreement in February, 2010, in which the government agreed to recommend a reduced sentence, provided he accepted full responsibility for his actions.
Prior to his sentencing, Mr. Brown had been free on a $50,000 appearance bond. Once he completes his four-year jail term, he will serve three years of probation, during which he must not participate in penny stock offerings. He must also forfeit $4.78-million, the estimated proceeds from his crime.
Is this why domo and demo hate it?
The Securities and Exchange Commission announced an expected award of more than $30 million to a whistleblower who provided key original information that led to a successful SEC enforcement action.
The award will be the largest made by the SEC’s whistleblower program to date and the fourth award to a whistleblower living in a foreign country, demonstrating the program’s international reach.
“This whistleblower came to us with information about an ongoing fraud that would have been very difficult to detect,” said Andrew Ceresney, Director of the SEC’s Division of Enforcement. “This record-breaking award sends a strong message about our commitment to whistleblowers and the value they bring to law enforcement.”
Sean McKessy, Chief of the SEC’s Office of the Whistleblower, added, “This award of more than $30 million shows the international breadth of our whistleblower program as we effectively utilize valuable tips from anyone, anywhere to bring wrongdoers to justice. Whistleblowers from all over the world should feel similarly incentivized to come forward with credible information about potential violations of the U.S. securities laws.”
Ring in the new year (202) 551-4790
Do you receive any compensation for your time if a superior bid comes in?
A-- Insurance still cheap for longs and legal shorts.
B-- Naked shorts have the whistleblower program but space is limited.
C-- Even raymond "the spammer" has an option, SEC currently gathering info on the crooked newletters.
D-- Only 8 more days till Christmas, ground shipping no longer a reliable option.
In May 2014, Hillshire Brands announced it would acquire branded food products company Pinnacle Foods for cash and stock totaling $6.6 billion. The merger arbitrage team worked with the Gabelli consumer products analysts and concluded that the transaction was inconsistent with Hillshire’s shareholder value and, more importantly, seemed defensive. We felt that there were multiple avenues of success for Hillshire, particularly because the transaction was subject to Hillshire shareholder approval. When Hillshire was being split from Sara Lee, Brazilian meat producer JBS was speculated to have an interest in acquiring Hillshire for its higher margin, value-added food products. Other parties we believed might have an interest in acquiring Hillshire included Tyson and Hormel. On May 27, Pilgrim’s Pride, a poultry products company that is 75% owned by Brazil’s JBS, unveiled a $45 cash per share unsolicited bid for Hillshire Brands, which valued the company at $6.2 billion. Shortly thereafter, on May 29, Tyson Foods, a diversified protein producer and marketer, made an unsolicited proposal to acquire Hillshire for $50 cash per share, or about $6.8 billion. The bidding continued until Hillshire announced that its Board of Directors had authorized the company to provide information to Tyson and Pilgrim’s Pride to assist in making a bid for the company. In early June, Hillshire agreed to be acquired by Tyson Foods for $63 cash per share, or about $8.4 billion. We expect financial engineering to continue to play a major role in M&A activity.
The SEC is collecting penalties from them, Sullivan still snooping around and their Ocata short position is a ticking time bomb. Will it be defused and leave them with just an 8.5 reaming? Don't touch that dial, the bashchimps always fly into a posting frenzy when scared, don't forget the options option.
P.S. ace, do you get nervous now when mattutu asks you to deliver a package?
Worried about being set up by your boss while delivering a package for him? Afraid of bankruptcy and jail time? Don't forget about the whistleblower option, I'm sure others in your organization are considering it.