that's to say...take a pill that will disrupt the methane..NOT disrupt the microbiome. Was typing while listening to the Q&A session. This is a huge confirmation of some rumors that were floating around this board a long time back. This changes everything if we get both weight loss and an immediate drop in cholesterol with no side effects...seriously, mega-block buster if that pans out $multi-billion easy
My shares are on lock
Sentiment: Strong Buy
Killing it with this presentation. Pimentel's comments on weight loss and cholesterol are huge!
Just take a breath test for methane, take a pill that won't disrupt the methane and problems are gone...but you've gotta stay on the drug as it's not an antibiotic.
Love this news!
Expedited phase 2 and 3 as just mentioned
Many of you know that Sheff bought into SYN this past week and he's been tweeting some interesting things. I can't find this info anywhere online, so take it for what it's worth, but here's a recent post he's made:
New IBS-C target is intriguing to us: Synthetic Biologics presented preclinical animal data on SYN-010, a modified release form of an old, generic statin (lovastatin). This drug reduced Methanobrevibacter smithii levels in the ileum of rats administered a high-fat diet and improved stool water content. M. smithii is a methane-producing organism which is hypothesized to be an underlying cause of constipation. This finding suggest that SYN-010 may lower methane production in the guy. SYN anticipates starting a Phase II trial in ISB-C in 2Q:15 with top-line results in 2H:15 and is holding an Analyst Day on June 3 to describe this technology. We believe that this is a promising area for further research.
So we've got the MS week, this analyst day, C.diff news, and potential Trimesta partnership all coming up and all key drivers to be excited about.
Given that both C.diff and SYN-010 have had good initial data, this is a great time to be invested in SYN, IMO, and I don't think it's long before we are out of the 2's for good.
If anyone cares to comment on the above quote, ideally with a source, I'd really appreciate it!
Tweeted just before Riley speaks in roughly 2 hrs. Good chance these are related:
1st Annual Translational Microbiome Conference
Thursday, May 14, 2015
8:50am - 9:20am EDT
Jeffrey Riley, CEO, to present at this conference in Boston, MA.
Presentation Topic: "Pioneering Approaches to Protect the Microbiome."
Webcasting is not available at this forum.
Today is finally here. #IBS patients will have a "diag(know)sis". Stay tuned...
Could be that the research was on point and our little drug knocks out the methane and symptoms of IBS evaporate?
Lots going on here with SYN!
Can you quote this, because I didn't see anything. I did see that they weren't considering sending out the offer documents to shareholders, but those shareholders must be told how their options will be dealt with.
I'd guess this is what you're referring to, unless I missed something?
Got into NVGN, sadly a very small position...but a position nonetheless, at $7.5, and then orphan drug status! Should be a good open tomorrow. Very much like the options granted to shareholders by May 1st. Will be buying more to lock in additional options. Would love to buy shares anytime in the next 5 years for roughly $8 USD/share. Yes please!!
If I were to sell shares after the 1st of May, then I'd still hold the options? So you'd expect this to fall by the value of those contracts after the 1st, like an ex-div play.
This is a great deal for retail investors, and I'll be buying what I can, even if we open 10+ tonight.
Hey Gizmo, what do you make of the offering news by NVGN? Looks like they'll be extending the same buying options to shareholders on record by the 1st of May? Would appreciate your thoughts here as I don't completely understand the offering. Am considering buying on this news, and anticipating a drop from this news to the $5's
Thanks for this Gizmo, NVGN looks like a solid company. Doing DD on them now. What are your believed entry price targets? How strong is their pipeline? I see the melanoma drug seemed to wipe out the cancer and the brain stem cancer drug seems to be doing the same. With such a low float, this is the type of stock I like. Would appreciate your thoughts on the pipeline and entry points.
Thanks in advance!
Anyone got any further updates on those patents that were filed when the MRI results started coming in? I know two of them seem to have surfaced, but haven't seen any mention of the other two. Perhaps this is why we're being held up before a deal is announced?
So I've just recently reentered APHB as I do like their pipeline and their direct and vocal connection to XON and other Kirk enterprises. I also like that they are working with the US Army in developing one of their drugs. Some DD will quickly lead you to the chatter of a reverse split at a 50:1 ratio to attempt to bring them up to market standards. I'm cautious about this, as RS can either be received well or can turn south quickly. I view the company as a very high risk play, needing at least 14 months to play out to any level of return. I do like the huge sum invested on behalf of RJK, which is about all the conviction I need. Wouldn't go full into this one, but will continue to nibble. Would appreciate any additional feedback here.
What's the boards thoughts on APHB? I was long a while back, bought in around .45 and sold around there as wasn't in for more than just a trade. Haven't spend a lot of time into DD on the company but know that Kirk has 44m shares and they've got some ambitious plans to list on a proper market. Also, know that they are partnered with the US Army for infectious diseases. What does everyone think? I'm gonna start nibbling here after some more DD, and would consider this a very risky, long term hold. I think the story needs at least 14 months to get any traction.
Sitting content with my SYN shares and love the family of interconnected bios that Kirk has put together.