My wallet is being "fast tracked"
Sentiment: Strong Buy
the agenda of their crony bosses long tern, to drop the price and buy the company?? hummmm
Sentiment: Strong Buy
upit 4 shorts..
Inovio Pharmaceuticals, Inc. (Nasdaq: INO) announced that its Ebola vaccine, INO-4212, was safe, tolerable, and generated strong T cell and antibody responses in its fully enrolled phase I study of 75 healthy subjects. Detailed immunogenicity and safety data is being prepared for peer-reviewed publication. In previously reported preclinical testing in mice and non-human primates, the Ebola vaccine protected 100% of immunized animals from sickness and death following exposure to a lethal dose of Ebola virus.
This human study (CT.gov: NCT02464670) was conducted by an Inovio-led consortium, which was selected and awarded $45 million by the U.S. Defense Advanced Research Projects Agency (DARPA) in 2015 to take a multi-faceted approach to prevent and treat Ebola infection.
This initial trial evaluated INO-4212 in five groups of healthy subjects. INO-4212 consists of two optimized SynCon® DNA plasmids coding for the Ebola glycoprotein antigen from circulating Ebola strains from 1975 - 2014. These plasmids were tested separately and together in muscle and skin in five study arms, one including Inovio’s DNA-based IL-12 immune activator. Of 69 evaluated subjects, 64 (92.7%) seroconverted and mounted a strong antibody response to the Ebola glycoprotein antigen following the three dose immunization regimen; 48 subjects (69.6%) seroconverted after only two doses.
Significantly, in the study arm using intradermal (skin) administration, 13 of 13 evaluable subjects (100%) generated antigen-specific antibody responses after only two doses and all remained seropositive after three immunizations. Similarly, in the study arm receiving the vaccine with intramuscular administration in combination with plasmid IL-12, 12 of 13 evaluable subjects (92.3%) demonstrated strong antibody responses after only two immunizations and 13 of 13 (100%) produced strong antibody responses after three immunizations.
The Ebola glycoprotein specific geometric mean antibody titers measured in the five cohorts ranged from over 2,000 to greater than 46,000. Significantly, a majority of vaccinated subjects in each of the five cohorts produced strong Ebola antigen specific T-cell responses as measured by interferon gamma ELISpot analysis.
To date INO-4212 has been well tolerated and has not demonstrated systemic serious adverse effects, such as fever, joint pain, and low white blood cell counts, reported in association with some viral vector based Ebola vaccines currently in development. Moreover, unlike the viral vectored vaccines which must be kept frozen, INO-4212 was formulated in a solution which was kept refrigerated (2-8 C).
Inovio was recognized by industry peers for "Best Therapeutic Vaccine" for its DNA-based immunotherapy, VGX-3100, a first-in-class product for treating high grade cervical neoplasia associated with human papillomavirus (HPV). Medical researchers have previously tried to stimulate therapeutic immune responses against HPV and cervical lesions with little success. Inovio’s phase II data from this immunotherapy demonstrated that robust CD8+ killer T cells activated in the body by VGX-3100 were correlated to the clearance of neoplastic cervical lesions as well as the virus which caused the disease. These results were statistically significant and clinically relevant, and were published last year in a peer-reviewed article in The Lancet, one of the world's leading medical journals. Inovio will take VGX-3100 into a phase III trial later this year.
Each year, the ViE award recognizes the therapeutic vaccine that addresses an unmet medical need and holds significant potential for vast geographical and market reach. This is the fourth consecutive year that Inovio's lead product has won this designation.
Dr. J. Joseph Kim, President and CEO, said, "Women around the world with HPV-related cervical pre-cancers would ideally have access to an effective non-surgical treatment to prevent progression to cancer. We greatly appreciate the World Vaccine Congress' recognition of the potential of Inovio's VGX-3100 to address this opportunity.”
Your mind hasent worked for longer than that !!
Sentiment: Strong Buy
Why would you share with Europe intellectual knowledge and no cash to be earned there ,when MedImmune will have the exclusive rights to develop and commercialize here in the USA and then receive royalties on worldwide net sales for these additional cancer vaccine products ..I think this was a great move.