Had to do some research on what you were referring to about the KP Kaiser Permanente.
Yeah Retro studies are like you said: Great, but there is so many variables to consider. Had to do these for Statistics in college and had to learn that there is a lot to consider.
Excerpt from Abstract mentioned by J Brantz
Estriol likely inhibits iNOS gene expression since the hormone blocks LPS induction of iNOS RNA levels. The pro-inflammatory cytokines IFN-gamma and TNF-alpha are believed to be important modulators of multiple sclerosis. Here, we demonstrate that estrogens and progesterone also inhibit NO production by microglial cells activated in response to these cytokines. Activated microglia elicit TNF-alpha in addition to NO and we further demonstrate that estrogens and progesterone repress TNF-alpha production by these cells. Finally, estriol and progesterone, at concentrations consistent with late pregnancy, inhibit NO and TNF-alpha production by activated microglia, suggesting that hormone inhibition of microglial cell activation may contribute to the decreased severity of multiple sclerosis symptoms commonly associated with pregnancy.
An answer to your question earlier: As I asked this directly to the company and received this response: The data WILL be released Concurrent to Dr. Voskuhl's presentation. So, it means that it will probably be released on that day for sure or minutes before the presentation because it is considered "Material Information" in which they need to make it publicly available...at least in abstract form.
You say it so much more Professionally.
Thank You very much for this post.
It is inconclusive until we know more.
The pill comes in 2 forms: combination pills and progestin-only pills.
I think it is very wise to bring that article to the boards attention so it can be discussed tomorrow. I am with you on that one...it really has been widely prescribed in Europe.
I HONESTLY do NOT feel that we comparing Apples to Apples though. The combination of Estrogn and Progestin does NOT equal Estriol.
But I guess if it had to come up...now is a good time to discuss it.
DQ was right: Estrogen and Progestin so I was right!
If we are talking about the same article, that is the quote:
Hellwig noted that her team studied data for women who used oral contraceptives for at least three months, which limited the analysis because they weren’t able to study lifetime exposure. Though she expects to see an increased risk with longer use in their final analysis, which will be presented at the upcoming American Academy of Neurology’s Annual Meeting. Most of the women used an estrogen and progestin formulation of birth control, a commonly used combination.
While this preliminary analysis indicates an association, researchers cannot firmly establish causality, Hellwig warns.
“We say the use of birth control might explain a little bit of the increasing incidence [of MS] among women, but only to a small amount… [We] don’t intend to mean that young women should avoid birth control to avoid MS,” she said.
Are we Cross?
You know, I just don't think I could bear it if we weren't friends anymore.
Ok I will put these fat fingers to rest.
Ok...now we can be friends again!
All joking aside...I will carefully read the article again and take some time to form an opinion that will hopefully meet your passionate demands.
I don't recall what the control was randomized to... 2-1 is the norm - anyone know for sure?
As far as other products to market: The C. Diff is the main one that will or should be the money maker for SYN and it will come to market much quicker as than people think. Why? They can jump to a Phase II ... it is realistic that in 4 years this could be on the market -- the trials should be definable and quick. The pertussis drug...really quick also.
The IBS drug: I am very tired so someone please correct me if I'm wrong as I am too lazy at the moment to look into my notes...but I believe it is a form of an approved drug which means direct into a Phase II also.
This is another reason why I believe this is an undervalued company...I posted this before but cannot recall. I apologize, but will look this up for sure.
Sifting through all my scattered and unorganized notes will take too much brain power tonight.
If you are really interested go to their site and listen to all the Jeff Riley Conference calls you can.
I know I have seen your name Mdofthesea around somewhere??
Those are Excellent Questions by the way to ask to any forum!
If this was referred to me...Let's play fair here: I was eluding to the same article you are.
Our info is embargoed until the same date...maybe they can have a #$%$ contest.
OK, I cannot help myself: You also have to study What Kind of Contraceptives were used? Many of them have a progesterone base to them...now that couldn't be compared to estriol.
This is why I wrote Inconclusive in my notes after reading this article and comparing it with the true Estriol and Estrogen studies alone.
Alright, even though I have much more to say...I tired of moving these fat swelled up fingers across my keyboard.
Just one more comment: 1 in 1000 women have MS ... this study was of less than 500 women...to have a valid, reliable study, you would need to study at least 10,000 women and it would have to be an in DEPTH study of their backgrounds and this study would have to last at least 10 Years to have any definite conclusion.
Also: Multiple Sclerosis is 50% more common than once thought....so when they dive deeper into this study, I believe they will find that these women had already HAD it BEFORE....the contraceptives were actually HELPING them.
Yeah: last visit to that website was on March 14th and I copied it and put it in my notes.
Here is what I wrote about this: Women could of already had MS prior to this and the stopping of birth control pills caused a "Relapse"
So this actually could work in our favor...but it is inconclusive because it is a non-clinical study.
That is what I was thinking also.
Go read the studies on Pubmed
Most favor contraceptives that they lesson disability and relapse rates.
I haven't read much lately but I know I recall reading these when I was researching this about four months ago.
I read the Hellwig theories and she is bound and determined to say that contraceptives cause MS.
Yeah I've read that article and many others.
Estriol has been proven safe in long term studies in Europe and other countries..
Contraceptives are not estriol and consider all the variables involved with these contraceptives..
But, we will know for sure in about 11 days.
Trade according to your personal beliefs and strategies.
This is OLD, OLD and I have read these types of inconclusive reports before. I am surprised someone hasn't brought this up a long time ago...maybe they did.
There are so many Contradiction studies out there it is not funny...now we have a Clinical Meaningful Study coming out in a couple weeks.
What matters is the study by Dr. Voskuhl which is a purity of estrogen called estriol. These kinds of minute studies that are inconclusive is what has been manipulating the FDA.
I wonder why so many doctors prescribe Estrogen based pills to their patients with MS?
Just wait for the results.