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Trius Therapeutics, Inc. (TSRX) Message Board

golongin2008 163 posts  |  Last Activity: Oct 15, 2014 10:40 PM Member since: Nov 25, 2008
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  • Reply to

    OT: VTSI

    by uptabdowntab Oct 15, 2014 6:24 PM
    golongin2008 golongin2008 Oct 15, 2014 10:40 PM Flag

    OMG... Are we down to these types of posts now from a penny stock promoter wantabe? Good grief...
    Can't we hear from the folks who actually still own this name, if any are left? At least the Twitter stock
    guru guy, who some think may have bailed, had/has some positive things to say and report about the company. Hey...forgive and forget. At least his posts were entertaining and positive....

  • Reply to

    scare job by MMs going on

    by babyfaze122 Oct 13, 2014 10:06 AM
    golongin2008 golongin2008 Oct 13, 2014 2:17 PM Flag

    Hanna.... Not even sure now it is an issue of trusting the science. The time table to FDA approval is at least 4 years away. If you don't believe me go talk with IR. So between now and then catalysts for upward stock movement are going to be six months to a year apart. Also, the needs to raise money to fund the trials should be obvious. At $6 a share that would of been not so ultra dilutive. At $2 or less, it will be very dilutive.

    Look...I'm ultra long, and at prices more than double what it is trading at today. But there is a reason the stock keeps hitting new lows just about every other day. This is going to be a very long road. 95% of the people who are posting here and who are ultra bullish won't be around for the pay off, if there ever is one. In fact, most will be long gone before the end of 2014. I've seen this literally dozens and dozens of times on message boards during the last 20 years.

    People here aren't your friends, nor your enemies. They're simply trying to make a buck.
    Just like all of us are. Misery likes company, and dillusion, so that's when the ultra bullish posts
    really start to appear and usualy are crying "shorts" on top of MM's trying to steal your shares.
    If one feels better grouping themselves with like minds that's fine, but those here now, including myself, don't know crapola, otherwise we would have all sold when the stock was over $6.50!

    Reality check time, not bashing........

  • Reply to

    scare job by MMs going on

    by babyfaze122 Oct 13, 2014 10:06 AM
    golongin2008 golongin2008 Oct 13, 2014 10:10 AM Flag

    Think you and others here have been saying this since $6?

  • Reply to

    LOOKS LIKE MATUSOW PULLED A FAST ONE ON YOU

    by walllstcz Oct 9, 2014 9:03 PM
    golongin2008 golongin2008 Oct 11, 2014 2:59 PM Flag

    Yes...Definitely a $5 company, in your friggin stupid #$%$ mind. Listen dip sheet...You think Cowen can simply dump a stock worth $5 at $15 for 30 million dollars less than a month ago because of "hype" posted from some idiot Twitter stock guru? Come on man.....

  • golongin2008 golongin2008 Oct 8, 2014 3:42 PM Flag

    Exactly.

  • golongin2008 golongin2008 Oct 8, 2014 3:38 PM Flag

    Dosage is key in RNAi technology. It's gene suppression technology for goodness sakes. Too much and the entire gene that generates a programed response could be surpressed. Too little, and you do not get the desired result. The idea is to get the optimal dosage for the results desired without surpressing the gene too much. Kind of like making a Margarita! Too much juice and there's no effect. Too little juice and you're totally wasted.

  • Would help clear things up I would think?

  • golongin2008 by golongin2008 Oct 8, 2014 11:18 AM Flag

    RNAi company...Results with lower dosage miss efficacy targets... Stock down -47%,,,
    Won't help us....

  • Reply to

    Now we have good results on Phase 2a.

    by orchids3333 Oct 7, 2014 7:26 PM
    golongin2008 golongin2008 Oct 8, 2014 9:59 AM Flag

    If they ever want to get the drug approved they better well have a SPA with the FDA for their pivotal
    Phase 3 trial....lol!

  • Reply to

    Now we have good results on Phase 2a.

    by orchids3333 Oct 7, 2014 7:26 PM
    golongin2008 golongin2008 Oct 8, 2014 9:50 AM Flag

    No.... But sometimes they allow a combined Phase2b and a Phase3, but it's pretty rare. This could be
    one of those situations however because the drug is cosmetic, and any material adverse effects could probably be observed fairly easily. One the other hand RNAi is a fairly new technology so the FDA may want to be real careful with any new applications coming out of the box. My bet is they require a Phase 3 but it won't likely be a huge group...Maybe 60-100 subjects...max.

  • Reply to

    Now we have good results on Phase 2a.

    by orchids3333 Oct 7, 2014 7:26 PM
    golongin2008 golongin2008 Oct 7, 2014 10:05 PM Flag

    We're a long ways off Orchids from FDA approval.... The Phase 2a was tiny.... Next we do a Phase 2b which should be about 40 trial participants I suspect. Before that we will meet with the FDA probably numerous times to arrive at a "SPA"....Strategic Protocol Agreement....The SPA will specify how the trials will be run, who will run them, who will analyze the data, where the trials will be conducted, and the burden
    of proof, and standards of proof, for trial success. Once the SPA is out of the way, actual patient enrollment
    will start. That could take 3-6 months I suspect at a minimum. So you're probably talking mid to late 2015 for the Phase 2b trials to even commence. Then six months to a year from completion the results to be analyzed
    and if they are positive, to commence a pivotal Phase 3 trial. Again, if all goes well, I would suspect FDA approval sometime in late 2017, or early 2018.

  • golongin2008 golongin2008 Oct 7, 2014 3:29 PM Flag

    The stock is off it all time lows by only .20 so hardly time to start patting yourself on the back.
    Still lots of disbelievers out there apparently. Let's say the company is learning to walk now,
    which is a long way from sprinting......Keep the faith, but also keep some perspective.

  • Reply to

    Thanks Dr. C for clearing up the confusion

    by orchids3333 Oct 7, 2014 10:23 AM
    golongin2008 golongin2008 Oct 7, 2014 2:39 PM Flag

    Saw the presentation and picture analysis and I must say I'm impressed with the 3 month results.
    Definitely a difference and one that most people would gladly pay for it that were your stomach above
    the swim trunk or bikini lines. No doubt proof of concept is established now. Stock at these levels is an
    outright joke.

  • Reply to

    SODA anyone?

    by hoss_99999 Oct 1, 2014 2:30 PM
    golongin2008 golongin2008 Oct 7, 2014 1:56 PM Flag

    Thanks Tween, and certainly glad to have someone here with an accurate memory.
    I owned IDRA for a tad, but also sold that one on the run up into the 5's and got alot of
    thumbs down posts on that Board too for posting my sells and rationales...! LOL...

    You don't get any misses with these microcap bios. They crush you if the first trial data isn't
    great. When the Baker Bros started dumping that was also my hint to hasta la vista. Those guys have
    had a tough year or so frankly...lol!

    Siga? No doubt in my mind we could have merged with CMRX when it was a private company
    and was just starting the protest stuff re the BARDA contract. But like everything else here, egos
    apparently got in the way and Siga was "feeling it's oats" and just dismissed them as a pesty start
    up venture. Wrong. Their attorney ate our lunch in the protest, and the rest so they say, is history.

    Where could Siga have been? Everyone here could have been very rich, that's all I know...

  • Reply to

    Thanks Dr. C for clearing up the confusion

    by orchids3333 Oct 7, 2014 10:23 AM
    golongin2008 golongin2008 Oct 7, 2014 1:44 PM Flag

    Haven't seen the pictures yet but certainly glad to hear they look good.
    Broadcast will be available within the next hour apparently.

    The stock is still 43% down from where we were prior to the "disaster" presentation.
    Still a very long way to go gang to recoup our losses, but at least it's a start.
    Congrats to Dr. "C" for the effort to clear things up!
    Let's hope today is just the start for a bright future for this company.

  • Reply to

    SODA anyone?

    by hoss_99999 Oct 1, 2014 2:30 PM
    golongin2008 golongin2008 Oct 7, 2014 1:06 PM Flag

    Drod...You DID NOT take a bath in CLSN....You either broke even, or even made money in that name, as you posted here numerous times that you just bailed on the stock, by "chance", before the trial news. I only made 125k on CLSN selling before the trial results were announced, plus I warned others to consider selling...including you....but you didn't like my rationales....LOL! I'd say we're more than even right now my friend! LOL!

  • Reply to

    SODA anyone?

    by hoss_99999 Oct 1, 2014 2:30 PM
    golongin2008 golongin2008 Oct 7, 2014 11:15 AM Flag

    Thanks Tween....Yes DRTX ended up being a homerun as did TRSX and TTPH...All in the antibiotic group. Bought CEMP large in the 9's and it's been acting technically good of late as well. Check the chart on that one. Could just be hot money from TTPH and DRTX going into it but that one could be the next one. More of a crapshoot like TTPH was is AKAO. Own RLYP in hyperkalemia space...One competitor that I know of out there in ZSPH. Also own MDCO, BLUE and MGNX. There you have it! IMHO of course and everyone should do their own DD! GL

  • Reply to

    SODA anyone?

    by hoss_99999 Oct 1, 2014 2:30 PM
    golongin2008 golongin2008 Oct 7, 2014 10:39 AM Flag

    Drod....Still have this SODA from 35's and I seldom look at it until today and saw it's at $21??
    Killing me. I know you bought MDWD and took a bath on that one, but I'm getting killed even worse on SODA... Should I sell it? What did you do with yours? TIA * Yes.. I know people I.said I wouldn't post here again but it's the only way I know how to reach Drod... TIA

  • Reply to

    GOOD LUCK DR. C

    by lottawatta2013 Oct 7, 2014 7:53 AM
    golongin2008 golongin2008 Oct 7, 2014 10:16 AM Flag

    How about simply using a phrase like "visual clinical benefits" over placebo. Clinical simply means that it appears to work chemically and organically but not to the extent that may end up providing the visual clinical benefits that everyone has hoped for. Two different hurdles frankly.

  • Reply to

    GOOD LUCK DR. C

    by lottawatta2013 Oct 7, 2014 7:53 AM
    golongin2008 golongin2008 Oct 7, 2014 10:10 AM Flag

    I'm sorry but I just don't like C saying it shows a "clinical benefit" over placebo. I know it is still early in
    the game even at 3 months, but if you can't say your treatment provides a "substantial clinical benefit" over
    water for goodness sakes, why say, or present anything once again. Wait until you have something that is substantial, or of obvious benefit over water, before presenting anything for goodness sakes!!!

    Those who fail Clinical Phase 3 trials often state in their press releases that their drug showed "clinical
    benefits" but did not meet statistical significance in their trials. Here we're using the same term which to me
    is NOT positive. Again we need at least a 65% visual improvement over placebo to make this work. End of story.

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