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Trius Therapeutics, Inc. (TSRX) Message Board

golongin2008 153 posts  |  Last Activity: Jul 8, 2014 12:30 PM Member since: Nov 25, 2008
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  • Reply to

    Well... I'm in.

    by joshkin20 Apr 10, 2014 10:18 AM
    golongin2008 golongin2008 Apr 10, 2014 10:44 AM Flag

    Think if you're patient and don't expect $18-$20 within a few months, you will do very well buying at these levels.... You have at least four major firms who think this is a $20 stock. It is. IMHO!!

  • Reply to

    Market Cap @ $335Mil

    by beavertail_splash Apr 7, 2014 10:51 AM
    golongin2008 golongin2008 Apr 10, 2014 4:56 PM Flag

    Think most conservative estimates for dalbavancin are in the 400 mil range. Bought more today at
    $12.58 and I already own a ton from $7....

  • golongin2008 golongin2008 Apr 10, 2014 4:58 PM Flag

    Yes...If only Siga made a smallpox vaccine that would be really relevant. But unfortunately they make
    a smallpox antiviral for the limited folks who can't take a vaccine.....

  • Reply to

    Market Cap @ $335Mil

    by beavertail_splash Apr 7, 2014 10:51 AM
    golongin2008 golongin2008 Apr 10, 2014 6:31 PM Flag

    Institutions missed on TSRX and will miss on DRTX. Too small of float for them to get involved. This is a retail play for the smart folks, and there aren't a lot of them out there frankly. The stock is worth $18-$22 so at $12 plus, with FDA approval a given, and a 400 million potential market for dalba, the risk reward heavily favors buying now IMHO.

  • Reply to


    by wm.craigbarnard Apr 11, 2014 5:26 PM
    golongin2008 golongin2008 Apr 13, 2014 9:38 PM Flag

    Craigbarnard... First of all...welcome to the Board.. I have been in this name large since 7. TSRX before that from $4 and it was acquired by CBST for $15 plus...Also own TTPH, CEMP and AKAO in the antibiotic space.

    Your post was somewhat confusing frankly. The May 26th PDUFA is all but a formality. The drug already went through FDA panel vote just a few weeks ago with unanimous recommendation to approve. The stock did not rally much on that news, and will not rally much on final FDA approval because that is already assumed. Phase 2 results were a few years ago. I believe you are referring to FDA approval after a Phase 3 is successfully completed. That's a done deal. Only issues before the final FDA committee vote is labeling, and post approval trials. Effectiveness and dosage was already established in the Phase 2 and 3 trials and there is no issue with that either.

    This company is not typical. This is no screaming #$%$ shoot pie in the sky cancer or Hep "C" drug. This is a real company with much needed once per week IV induced antibiotic to treat gram positive bacterial infections. IMHO only it is a likely acquisition target, much like TSRX was. Four firms have $18-$20 price targets on it. Just wondering where you might have come upon DRTX?.

  • Anybody here still think that the psoriasis trial results had no effect on the recent drop in the share price by 50% from just a few weeks ago? Just wondering.

  • Reply to


    by ymeddyliwr Apr 14, 2014 5:16 PM
    golongin2008 golongin2008 Apr 14, 2014 7:07 PM Flag

    Second your sentiments to a tee Silver! Nice summary.............

  • Reply to


    by ymeddyliwr Apr 14, 2014 5:16 PM
    golongin2008 golongin2008 Apr 14, 2014 7:30 PM Flag

    Ymeddyliwr.... need to calm down, relax, and restore brain order. Your anxiety is what those selling short are attempting to cause, so don't play into their hands.

    There is nothing wrong whatsoever with DRTX...the company. A secondary offering at some point in time is not "bad". If done at the right price it could be very "good" for the company and its shareholders.

    Label restrictions? Definitely . Was already mentioned during the panel meeting. The label will state it is not for pediatric use. It will state it is not for pregnant women. It will state that if you have liver issues you should consult with your physician before taking; The FDA may well require post trial studies involving liver issues.
    Black box warning? Are you serious? When did the drug last kill someone? Come on up on what you own...Seriously. Delay of approval? No way. Vote was unanimous to approve by the panel. What would the delay be for? You're starting to sound a bit paranoid frankly.

    Have you bothered to look at how the other antibiotic stocks have been trading of late.

    TTPH....$17.7 to $9.02
    CEMP.... $15.39 to $8.85
    AKAO.....$21.25 to $13.30
    CBST......$82 to $61.66

    Not sure why you would have invested heaving "over time"..."over the years" and ridden out the uncertain times, and now are on the verge of panic just before FDA approval, and a very bright future for the company? That to me is more perplexing than how the stock has performed of late. May I respectfully
    suggest that once order is restored and this stock regains its former glory days and you ultimately sell,
    that you swear of biotech investing for the remainder of your days! Seriously.

  • If that is the case what are we worth? A heck of a lot more than $3.45, that's for sure!

  • golongin2008 by golongin2008 Apr 15, 2014 12:18 PM Flag

    The nut job(s) here are having a nervous breakdown creating new IDs just about every day and are now copying and posting old posts from either me or Drod on unrelated Siga topics. The person or persons are truly nuts. Mental health is a very serious issue in the US and this Board proves it beyond a doubt. Some here need to be in locked wards...Seriously.

  • golongin2008 by golongin2008 Apr 15, 2014 2:26 PM Flag

    Hope you bailed on that one. You know I sold at $4.80 and you were kinda critical of that, but
    it's not the "real deal" IMHO. Once a drug, or platform, fails the earliest indicated trial for whatever reasons
    the company, or message "posters" may tell you, get the heck out. Can't think of an exception. In bios
    sometimes your first loss, is your best loss. DRTX will recoup it for yah though!

  • golongin2008 golongin2008 Apr 15, 2014 2:49 PM Flag

    Thanks, but Phase 1 data is almost totally irrelevant unless the drug is flat out toxic. And terms like "dose dependent effects" sound like the release from IDRA after their early psorarsis trial showed lousy efficacy,
    but claimed "activity" and "proof of concept".

    This proof of concept stuff by some companies is plain BS. In our trial the drug, as delivered, will either show substantial reduced scarring over the norm or non treated group, or it will not. No way to ginger bread that when the results are released. Fingers crossed, and very long.

  • golongin2008 golongin2008 Apr 15, 2014 3:19 PM Flag

    No...the results were very good in the Phase 1 as far as it went and the drug seemed well tolerated as well.
    I'm just very skeptical of Phase 1 results, as the trial sample is usually very small, and the patients are sometimes cherry picked, etc. The Phase 2 (or 1a whatever they may call it) will be much more telling
    as we'll see the entire spectrum of increased patients; side effects; and effects of varying dosages etc.
    If they can repeat the Phase 1 results, or do even better, in a much larger sample size, then we could well
    have a huge winner here. I mean a 47% reduction is scarring from the use of a topical cream (or other non invasive application), would become state of the art following surgery very quickly. A huge market potential.

  • Reply to


    by ymeddyliwr Apr 14, 2014 5:16 PM
    golongin2008 golongin2008 Apr 15, 2014 4:09 PM Flag

    Good for you Minnie....I thought long and hard re IDRA and have been in that situation before and fought the urge to hold it after the brief rally from the psorarsis results. Glad I sold but you did better than I on your first batch of sales in the mid 5's... Nice.

    You want a small spec biotech that "could be" huge. Read up on RXII. I own it large from around $3.50.
    RNAi company with a guru CEO that was one of the major discovers of RNAi. Using their first product to treat surgical scarring. 43% reduction from placebo in Phase 1 trials and no known safety or usuage issues.
    Could be a 5 billion dollar worldwide market. Read up on it and let me know your thoughts. Their product is not a delivery system like ALNY or TKMR etc. The drug and the delivery are one and the same using
    RXII technology, so it can be systemically potentially used for any number of drugs and treatments, aka

  • Reply to


    by ymeddyliwr Apr 14, 2014 5:16 PM
    golongin2008 golongin2008 Apr 15, 2014 8:47 PM Flag

    stock_lurker.... Good post and well reasoned. I've been in bios for 25 years starting with the mother of all bios...Genentech. Your thoughts are right on. Been involved is some good buyouts, the last being TSRX by CBST last year for around $16. Was in that name large from the 4's.

    In the antibiotic space a lot of competition is coming aboard. Not only the new companies like TSRX and DRTX, but generic competition as well. Pricing will be key going forward. The differences between choosing one over the other primarily money. If Dalb can be cost competitive, plus save the hospitals a patient lying around in a hospital room for a week receiving antibiotics, (when they could do it once a week on an out patient basis) such is a big advantage for DRTX.

    Going it alone I would hate, and would probably sell on that news. Saw what that did to AMRN, and I have no desire to live through that nightmare again with DRTX. You have to have a very large sales force behind your product, PLUS, the ability to bundle it with other drugs to come out on top. Trying to undercut a CBST purely on price is going to be a loser IMHO. And the costs and dilution to current shareholders in starting up a large sales force, and mfg and distribution, would be substantial. No thanks.

    I frankly foresee a buyout of DRTX in the high teens within six months following approval.
    At least that is what my personal Tara cards read...LOL! GL to you and all longs!

  • Reply to


    by drod4ball Apr 15, 2014 11:17 AM
    golongin2008 golongin2008 Apr 15, 2014 8:57 PM Flag

    Siana....Definitely not beginning. A lot of bios down 30%-60% off their highs within a few weeks so it's been brutal. I have the deep scars to prove it too!

    Do not feel it is over yet either. I think we might see a little more rally in the group then they'll hit it hard again and drive out the rest of those buying on the dips thinking the bloodbath is "over". But once that is over the rebuilding phase will take it's place and that could go on for months. A lot of damage has been done technically in the last few weeks, and they'll be a lot of people trying to get out of their positions as the stocks move up. Perhaps by the end of summer the damage will be repaired and normal order resumed, but that's only a guess. Nobody said it was easy did they? LOL!

  • Ironically, Ebola was one indication for ST-246/247 that the company felt could be developed via their pipeline.
    They may have even started preliminary studies on the feasibility of pursuing it. Maybe even received some modest grant money to pursue it. Then...nothing.

    Not only would that had been a big money maker today given the outbreak and spread of Ebola in Africa,
    but the PR and goodwill for the company would have been worth it's weight in gold. To dream the dreams of what could have been if only, etc. etc. ... What a shame.

  • Reply to

    Opinions - There sure are a lot of them

    by drh21530 Apr 15, 2014 11:16 PM
    golongin2008 golongin2008 Apr 16, 2014 12:13 AM Flag

    OK...good exercise before one turns in for bed I!

    1. Unmet medical need for this drug? Somewhat of an exaggeration frankly. The drug it was compared against, Zyvox, in the non inferiority studies, is marketed by Pfizer and has been out on the market for some time. The trial comparisons were very close. Dalb offers a once per week IV formula, while Zyvox is oral, or IV form, and must be taken daily. Think ours, being outpatient and once per week, is more convenient, thus gets the patient out of the hospital sooner, which is good for both the patient, and the hospital. I would prefer ours to be a once per week oral formulation which would be even better IMHO. Maybe in time.

    2. Vote by ADCOM was unanimous but so was the Trius (CBST) antibiotic that came before ours.
    We still had some labeling issues and probably some post approval safety monitoring, because of potential
    liver issues. Ours is not for pediatric use or pregnant women. No studies were done with either children or PG women.
    3. Have no clue.
    4. Lots of small companies out there that remain small...LOL Not sure I understand the point.
    5. Refer to above. If the implication is DRTX could be a target, then I agree
    6. Low float simply makes the stock more volatile up, or down. What's the point?
    7. Earnings are irrelevant at this point. Will be an anticipated loss.
    8. PUDFA date in May, and Dalb will be approved. Fully anticipated already and discounted.
    9. All time highs mean nothing unless you sold...Ditto with all time lows... LOL!
    10. Not sure about EU submission before the end of 2014 but probably highly likely.
    11. Quite a few firms have had buys on the stock for quite some time. Price targets were recently raised.
    12. Zyvox is a Pfizer drug. Tedlizoid was owned by Trius and acquired by Cubist. Competition in the space is starting to get very crowded IMHO, and some lead antibiotics are going generic next year, or the year after.
    DRTX will need to sell our drug on price and benefits.

  • Reply to

    Opinions - There sure are a lot of them

    by drh21530 Apr 15, 2014 11:16 PM
    golongin2008 golongin2008 Apr 16, 2014 9:50 AM Flag

    Sorry drh32530 for the tenor of my post. I thought your "exercise" was one intended to be totally objective, and not slanted towards all of our investments in DRTX. I guessed wrong re your motives, and sensitivities, and that was "my bad". I've posted here for almost a year now...I'm very long DRTX from $7, and have not sold one share.

    The use of some of your terms like "unmet need" is a word of art. All antibiotics are not an "unmet" need.
    Yes, we need more of them, and more effective ones, especially for gram negative bacteria's, but there are quite a few of them out there doing their job in gram positive bacteria's, so the field in general does not qualify as an "unmet" need under a strict definition. In fact, that part of the field is getting rather crowded IMHO.

    Was nothing personal. Sorry you took it that way. I misunderstood where you were coming from.
    Please continue to post your views. Again, my apologies.

  • Reply to

    Okay Fess Up

    by beavertail_splash Apr 16, 2014 9:48 AM
    golongin2008 golongin2008 Apr 16, 2014 10:02 AM Flag

    Beav....So many people want out of bios they're going to be selling on any rally. That and probably the shorts will start coming back on any prolonged rallies and start hitting the group again. Really brutal.

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