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Geron Corporation (GERN) Message Board

gosmokeadoobie 5 posts  |  Last Activity: Jan 31, 2015 8:28 PM Member since: Nov 27, 2012
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  • gosmokeadoobie by gosmokeadoobie Jan 31, 2015 8:28 PM Flag

    By Mayo Clinic Staff

    Hemoglobin (Hb or Hgb) is the protein in your red blood cells that carries oxygen. A low hemoglobin count is a below-average concentration of the oxygen-carrying hemoglobin proteins in your blood.

    A low hemoglobin count is generally defined as less than 13.5 grams of hemoglobin per deciliter (135 grams per liter) of blood for men and less than 12 grams per deciliter (120 grams per liter) for women. In children, the definition varies with age and sex. The threshold differs slightly between medical practices.

    A low hemoglobin count is a commonly seen blood test result. In many cases, a low hemoglobin count is only slightly lower than normal, isn't considered significant and causes no symptoms. A low hemoglobin count can also be caused by an abnormality or disease. In these situations, a low hemoglobin count is referred to as anemia.

  • Reply to

    Don't Give Up

    by irishtrader52 Jan 30, 2015 4:09 PM
    gosmokeadoobie gosmokeadoobie Jan 30, 2015 9:14 PM Flag

    irishtrader - is not a hemoglobin 9.1 barely cutting the mustard? what is tefferi's opinion?

  • Reply to

    What chances of fast track

    by pedmac2000 Jan 24, 2015 2:00 PM
    gosmokeadoobie gosmokeadoobie Jan 25, 2015 12:33 AM Flag

    actually, grn163L has been administered to more that 435 patients over the years.

  • gosmokeadoobie by gosmokeadoobie Jan 14, 2015 2:33 PM Flag

    The myeloproliferative neoplasms (MPNs), previously termed the myeloproliferative disorders, are characterized by the clonal proliferation of one or more hematopoietic cell lineages, predominantly in the bone marrow, but sometimes in the liver and spleen.

    In contrast to myelodysplastic syndromes (MDS), MPNs demonstrate terminal myeloid cell expansion into the peripheral blood.

    In the 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms, MPNs include: chronic myelogenous leukemia (CML), chronic neutrophilic leukemia, polycythemia vera (PV), primary myelofibrosis (PMF), essential thrombocythemia (ET), chronic eosinophilic leukemia, mastocytosis, and unclassifiable MPNs.

    Overlap disorders (MDS/ MPN) are those chronic myeloid disorders unable to be classified as "classic" MPN or MDS. These include: chronic myelomonocytic leukemia (CMML), atypical CML, juvenile myelomonocytic leukemia, and unclassifiable MDS/MPN.

  • gosmokeadoobie gosmokeadoobie Dec 7, 2014 9:04 PM Flag

    and it turns out that blood disorders (i.e., MF, AML, MDS, etc...) have super short telomeres and this appears to be why grn163L is effective in blood cancers and not solid tumors which have relatively "long" short telomeres.

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