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BioTime, Inc. Message Board

gosmokeadoobie 3 posts  |  Last Activity: Nov 6, 2014 3:33 PM Member since: Nov 27, 2012
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  • gosmokeadoobie by gosmokeadoobie Nov 6, 2014 3:33 PM Flag

    "Efficacy: There were 7 (21.2%) complete (CR; n=4) or partial (PR; n=3) remissions, occurring at a median of 5 cycles of treatment (range 1-9)."

    what's striking of the 7 remissions is that these remission all took place within 6 months or less of treatment. in other words, if you have MF (or some other blood disorder for that matter) you will know within months if you will be "cured".

    so, obviously, this drug works for certain types of patients. and now investors have to wait for tefferi to refine this subpopulation of patients.

    this investor reads this abstract data as a good thing.

  • Reply to

    Imetelstat Update II

    by irishtrader52 Oct 12, 2014 4:08 PM
    gosmokeadoobie gosmokeadoobie Oct 12, 2014 7:16 PM Flag

    sidesaddlex - it's interesting that you do not refer to the telomerase enzyme in your post. telomerase is what allows cancer cells to divide indefinitely.

    how and why telomerase is activated is unclear but telomerase is found in more than 90% of cancer types.

    it is believed that imetelstat inhibits telomerase activity in cancer types with short telomeres and blood cancers tend to have some of the shortest of telomeres.

    zarabesque - the geron corporation created TA-65 which is supposed to stimulate the telomerase enzyme NOT inhibit telomerase. and FYI ... geron is short for gerontology.

  • gosmokeadoobie by gosmokeadoobie Aug 23, 2014 3:50 PM Flag

    why no ASH 2014 submission?

    it's called politics. scarlett & tefferi are purposely keeping mum so as not to pollute the FDA review process.

    yes, it's that simple.

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