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iGo, Inc. Message Board

gswkool 48 posts  |  Last Activity: Jul 22, 2014 10:22 AM Member since: Jan 2, 2012
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  • Reply to

    FovistaTM Anti-PDGF Therapy

    by gswkool Jul 21, 2014 8:32 PM
    gswkool gswkool Jul 22, 2014 10:22 AM Flag

    Mick, thanks for the reply. I believe Novartis is or will be working on a combination drug i.e. whereby they can be delivered together. I am wondering if Tethadur will be able to deliver this combination drug - of course all this is a ways off. Just found it interesting. I think OPHT is looking at 2016 for possible approval of Fovista. Note that the Novartis deal, which was quite lucrative, was for Int'l rights only. OPHT kept US for themselves so far. I do think Fovista approval could have some level of negative implications for Lluvien, but not overly concerned -looking forward to the $25M payment which will be extremely helpful for PSDV........

  • FovistaTM is designed to target platelet derived growth factor (PDGF) in combination with anti-VEGF drugs to disrupt the formation of abnormal new blood vessels in wet AMD. In clinical trials, the combination of FovistaTM 1.5mg and an anti-VEGF therapy demonstrated statistically significant superiority compared to anti-VEGF monotherapy in terms of improvements in visual acuity, providing a 62% comparative benefit from baseline

    Company is symbol OPHT......they are not targeting a specific anti-vegf therapy; rather, they are targeting it to work with any approved anti-vegf therapy.......

  • Reply to

    stock price starting to move

    by gswkool Jun 28, 2014 11:35 AM
    gswkool gswkool Jul 21, 2014 8:23 PM Flag

    quarterly report was not so good. Not impressed on choco side of things. Demand is increasing for chocolate worldwide as middle class grows internationally. However, this will push up price of cocoa. RMCF too small -it's not nestle or hershey. So it may have problems with margins when cocoa price moves higher. They should divest choco business and go with yogurt. ....

  • gswkool by gswkool Jul 19, 2014 5:50 PM Flag

    Check out the company for symbol OPHT. Over billion dollar market cap. Got a great partnering deal. How does this bode for potential Lluven sales....? well, hopefully there will still be some market left....and $25M is $25M if it is approved....

    FovistaTM Anti-PDGF Therapy

    FovistaTM is designed to target platelet derived growth factor (PDGF) in combination with anti-VEGF drugs to disrupt the formation of abnormal new blood vessels in wet AMD. In clinical trials, the combination of FovistaTM 1.5mg and an anti-VEGF therapy demonstrated statistically significant superiority compared to anti-VEGF monotherapy in terms of improvements in visual acuity, providing a 62% comparative benefit from baseline.

  • Reply to

    Just A Guess On Roche

    by mickmack50 Jul 14, 2014 9:16 AM
    gswkool gswkool Jul 14, 2014 12:25 PM Flag

    Provided Lluvien gets approval in the U.S., why would anyone wish for a takeover? PSDV is far from reaching its potential. With $25M additional in the bank, they can continue to progress for the foreseeable future. The last thing I would want to see is a sellout . I'm not one for instant gratification. Anyhow, a little over eight weeks to go before a decision. If it goes against PSDV, then it will be time to reevaluate....GLTA

  • Reply to

    stock price starting to move

    by gswkool Jun 28, 2014 11:35 AM
    gswkool gswkool Jul 12, 2014 10:51 AM Flag

    better late than never. expect more progress on the yogurt front. so much for chocolate biz -progress there has been a dud.....

  • Reply to

    VERY FAVORABLE RISK/REWARD HERE BUY WITH BOTH FISTS

    by erp3359 Jun 29, 2014 4:13 PM
    gswkool gswkool Jul 12, 2014 9:44 AM Flag

    weeks or months to wait - not a big deal. I'll be happy if it happens before EOY. Still plenty of money to be made by/on MNTA. ...

  • gswkool gswkool Jul 6, 2014 10:58 AM Flag

    Markets will only be as rational as the people that participate in them. How many rational people do you know? How many rational people do you know that invest in the market? Most people don't have a clue...

  • Reply to

    VERY FAVORABLE RISK/REWARD HERE BUY WITH BOTH FISTS

    by erp3359 Jun 29, 2014 4:13 PM
    gswkool gswkool Jul 5, 2014 10:14 AM Flag

    they can try, -i agree with erporgene - the fat lady is singing -waiting on approval. I bought MNTA shares as I think it's possible there will only be one version of generic approved, and that I bet is MNTA. If I remember correctly, MNTA has an in with the FDA- The FDA has turned to it in the past for assistance. It should be interesting to see how this whole thing plays out.. I'm betting on MNTA....GLTA

  • Reply to

    Deaths:

    by redspinelpinktopaz Jul 5, 2014 8:59 AM
    gswkool gswkool Jul 5, 2014 9:57 AM Flag

    It's blinded so who knows? Only the clinical site(s) where adverse events occurred and the DSMB will know upon investigation. They will need to examine data and weigh the potential harm of adverse events against the potential efficacy of the drug. So, essentially, we will be getting our results early. If DSMB finds efficacy outweighs risks then great sign for ultimate approval. If they find reverse and stop trial from continuing, well, so much for their drug. It would be great if they could determine who is allergic before full administration -but I don't think that is possible. My gut feel is the news will be negative. So I will be selling and/or looking at stock options as a way to hedge against further loss if feasiblle......GLTA

  • ....not sayin' whether they are frivolous or not.....just feels like the stock is becoming more and more like a roach hotel..... in this case I don't think the market overreacted. In 8 weeks we will get the truth. My guess is that it will be unfavorable. The plunging stock price indicates many with similar assessment. Now the questions become -on bad news, how much further will it drop? Does it have potential to bounce back? I'm thinking sell now and take the tax loss.....I think I am done with this one ....GLTA

  • Reply to

    So, Is This Recent Move About Iluvien?

    by mickmack50 Jul 3, 2014 12:14 PM
    gswkool gswkool Jul 4, 2014 11:31 AM Flag

    Since April 21st, PSDV has moved up in price over 30% while ALIM has declined slightly. So, to me, the tea leaves indicate that the move is driven by other factors aside from Lluvien. There was the preclinical news on Tethadur and some announcement on plans for Medidur. Of course, plans for Medidur has tie in to Lluvien success. Lluvien approval in US has several benefits to PSDV, including shoring up cash position with $25M payment to PSDV from ALIM on approval, reduced clinical development timeline of Medidur, and of course royalties from sales in US. Regardless of the reason, I'm not complaining about the higher stock price. IMHO I believe a lot is riding on Lluvien US approval -with the overseas acceptance I think that bodes well for approval here -although FDA is a different animal.......just gotta sit back and hope for the best....GLTA

  • Reply to

    Price target 8$

    by federico_bisschop Jul 2, 2014 11:18 AM
    gswkool gswkool Jul 4, 2014 11:14 AM Flag

    good observations, -i have been holding this lemon for some time though, and it has yet to make lemonade. The news of the weak enrollment for a lead candidate was certainly not good news. I believe I read they are also in dispute with Bellerophon concerning criteria/scheduling of a bonus payment. Not good to be squabbling with the company that holds keys to your lead drug's development. I'm not selling my shares, but I'm certainly not buying more. What I've found from my years of investing is to reward companies with additional share purchases on good news and to do the reverse for those that disappoint......GLTA

  • recommended below $11. Continue to recommend under $11 & change. The reorganization is ongoing but it appears the stock bottomed under $11. They are making right moves -closing non-performing stores, reducing store size while maintaining most of their revenues. They are a popular internet site and are adding new online categories. Some will be successful and gain traction. Others they will discard. Ultimately, I think they will survive and continue to generate good cash flow. I could be wrong, but I don't put them in same camp as radio shack. One other thing to consider - the big shippers {UPS/FEX-Ex} have switched to dimensional weight pricing. This gives some pricing advantage back to retailers with box presence for some of their goods...GLTA

  • Reply to

    More delays for generic Copaxone

    by cmhe Jul 3, 2014 3:29 PM
    gswkool gswkool Jul 4, 2014 10:53 AM Flag

    Hilarious - a company that makes its living on generics trying to fight against competition for one of its own drugs - what it will get is a taste of its own medicine, so to speak.....a citizens petition -what's next? how bout a bunch of naked ladies standing in front of the FDA with signs saying "naked female genetalia against generic copaxone".....

  • interesting article. "Using a miniature model of the human intestine, only a few millimeters in size and made from stem cells, the scientists deactivated a gene in the cells tied to metabolic regulation called FOXO1. Once disabled, the cells began producing insulin. " possibly up ALNYs alley?

    "The method, described today in the journal Nature Communications, raises the possibility of replacing insulin-making pancreatic beta cells lost in diabetics by using a drug to retrain patients’ existing cells. While progress has been made in generating beta cells from stem cells, the method hasn’t yet produced ones with all the needed functions, said Domenico Accili, the study’s lead author. Plus, such cells would require transplantation. "

  • gswkool by gswkool Jun 30, 2014 9:44 PM Flag

    I looked at Alimera's market expansion plans for Lluvien and did not see anything for Asia. Are there future plans for expansion into Asia? Is there a market there for such a product? I would expect so.....?

  • happy with the upward stock price movement and the nice dividend.....GLTA

  • Reply to

    Pretty Soon IT Will Be 4 Months Since Complete Hold!!

    by mruyog Jun 27, 2014 10:15 AM
    gswkool gswkool Jun 28, 2014 11:19 AM Flag

    gotta question mgmt's competence vs an outfit like Mayo clinic. Mayo got their hold lifted. How long for GERN to get their hold removed? I am concerned about their competnece to do so as a shareholder. I'm giving it 6 months -if no news by then will re-evaluate my position....GLTA

  • gswkool by gswkool Jun 25, 2014 8:50 AM Flag

    symboll for Aerie Pharmaceuticals -check out the news today......

IGOI
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