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Amarin Corporation plc Message Board

homebuilder_watcher 208 posts  |  Last Activity: Jul 15, 2014 4:56 PM Member since: Dec 4, 2001
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  • homebuilder_watcher homebuilder_watcher May 14, 2014 8:45 AM Flag

    This has become a very long term investment

  • homebuilder_watcher by homebuilder_watcher May 14, 2014 8:33 AM Flag

    One whopping question on the call. I wonder if the number of listeners was in double digits? THere's no real business to talk about here, it's all about the lawsuits and there's really not much the company can say about them.Just a waiting game. This is pretty much an investment in lawsuits and hoping they come out on top/

  • Reply to

    Scotlandabrams

    by market_mania May 13, 2014 9:48 AM
    homebuilder_watcher homebuilder_watcher May 13, 2014 9:56 AM Flag

    Funny stuff market_mania/Halloween_candy. Epifix is superior to Grafix on every metric. Many doctors have weighed in who have used both and not single one opted to use Grafiix over EpiFix. But, keep on telling yourself that Grafix is better if it makes you feel better.

  • Reply to

    Homebuilder_watcher -

    by market_mania May 12, 2014 4:30 PM
    homebuilder_watcher homebuilder_watcher May 12, 2014 8:27 PM Flag

    No way the company is around beyond 2015 IMO

  • Reply to

    Earnings

    by cimcbride May 12, 2014 4:04 PM
    homebuilder_watcher homebuilder_watcher May 12, 2014 4:44 PM Flag

    Heck. If I can issue 5 million shares at $6.80 and raise $34 million, I'd be happy to buy some of them back in the mid $5s

  • Reply to

    ON ONE TICK AT THE CLOSE

    by iasimov201314 May 12, 2014 4:01 PM
    homebuilder_watcher homebuilder_watcher May 12, 2014 4:14 PM Flag

    Don't think I have ever seen an earnings release that doesn't even mention revenues except in the income statement below the PR,probably because they aren't worth mentioning. CEO of this company needs to go

  • Reply to

    Earnings

    by cimcbride May 12, 2014 4:04 PM
    homebuilder_watcher homebuilder_watcher May 12, 2014 4:09 PM Flag

    Wasn't everyone spouting off last quarter about how OSIR was profitable? Oh wait, that was profits from selling a division, rather than from actual operations. Leading company? With less than half the revenue of the actual leading company? Must be new math.

  • Reply to

    Journal article

    by homebuilder_watcher May 12, 2014 1:04 PM
    homebuilder_watcher homebuilder_watcher May 12, 2014 1:32 PM Flag

    Cite this article: Diabetic Ulcers Heal Faster if Skin Substitute Applied Weekly. Medscape. May 12, 2014.

    Diabetic Ulcers Heal Faster if Skin Substitute Applied Weekly
    Kathleen LoudenMay 12, 2014
    Almost twice as many persistent diabetic foot ulcers that underwent allografting with dehydrated human amnion/chorion membrane (EpiFix, MiMedx Group, Marietta, Georgia) completely healed, on average, with a weekly application vs once every other week, according to the results of new small trial.

    More frequent grafting not only healed the chronic ulcers 1.7 weeks more quickly than biweekly application, it did so without significantly increasing the number and cost of grafts, according to study coauthor Robert J. Snyder, DPM, from Barry University School of Podiatric Medicine, Miami Shores, Florida.

    "Results were really dramatic in the group of patients receiving the weekly application," Dr. Snyder told Medscape Medical News. "At the end of 4 weeks, 90% of wounds receiving weekly grafts healed vs 50% in the biweekly group."

    "There are very few treatments on the market that come close to this healing of diabetic foot ulcers," said Dr. Snyder, who is a consultant to the product's manufacturer, which funded the study.

    Potential to Improve Patient Satisfaction

    The new findings were presented last month in a poster at the Symposium on Advanced Wound Care (SAWC) Spring in Orlando, Florida and were published in the April issue of the International Wound Journal.

    The results seem encouraging, said Windy Cole, DPM, a wound-care specialist in private podiatric practice in Cleveland, Ohio, who did not participate in the study.

    "Although 1.7 weeks [faster healing] may not seem like a lot, it may make all the difference to the patient," Dr. Cole said in an interview with Medscape Medical News.

    "These wounds have a high incidence of infection, and quicker healing translates to a happier patient," she added.

    Small Single-Center Trial

    The comparative, parallel-group, single-center trial reported by Dr Snyder enrolled 40 patients with noninfected diabetic foot ulcers that had lasted for 4 weeks or longer and had failed to heal by 20% with conventional treatment. All patients underwent grafting with the dehydrated form of the amnion/chorion membrane, which is obtained from human donors' placenta after screening and testing for infectious diseases.

    Twenty patients each were randomly assigned to receive allografts either once weekly or every 2 weeks. All wounds were offloaded with a removable cast walker.


    There are very few treatments on the market that come close to this healing of diabetic foot ulcers.

    At study entry, the only significantly different clinical characteristic between groups was a higher mean hemoglobin A1c concentration in the weekly group (8.7% vs 7.3%; P = .036).

    The primary outcome was the mean time to complete reepithelialization of the wound without drainage or the need for a dressing.

    Wounds that received weekly grafts healed completely in an average of 2.4 ± 1.8 weeks compared with 4.1 ± 2.9 weeks in the biweekly group, a significant difference (P = .039).

    Number and Percentage of Diabetic Foot Ulcers Completely Healed

    Weeks of Treatment Biweekly Allografts (n = 20) Weekly Allografts (n = 20) P
    2 4 (20) 13 (65) .009
    4 10 (50) 18 (90) .014
    6 14 (70) 19 (95) .091
    8 15 (75) 20 (100) NA
    12 17 (85) 20 (100) NA
    NA = not available (not calculated)
    Similar Number of Grafts in Both Groups

    Each group received a similar number of grafts on each healed wound by the end of the 12-week study, the data show. The weekly group received 2.3 ± 1.8 grafts, and the biweekly group had 2.4 ± 1.5 grafts.

    Dr. Snyder explained that the number of grafts was similar because the patients in the weekly group healed more quickly. They also needed smaller pieces of graft tissue, which kept costs comparable between groups, he added.

    An advantage of this product, according to Dr. Snyder, is its availability in various sizes, from 1.5 sq cm and up, which decreases waste when the wound is small.

    Dr. Cole agreed this is a benefit, saying, "EpiFix is the new kid on the block. It is as effective, if not more effective, than comparable products but is significantly less costly than other skin substitutes such as Apligraf [Organogenesis, Canton, Massachusetts] because of its long shelf life and multiple sizes."

    The dehydrated product can be stored at room temperature for up to 5 years, the manufacturer says.

    EpiFix Should Not Be Last Resort

    "We want to give patients the latest and greatest in advanced wound healing, but our hands are being tied due to reduced Medicare reimbursement," Dr. Cole observed. "Because EpiFix costs less, we will be able to provide this product and still be a profitable center. That's huge."

    She believes that the application frequency of this amniotic membrane allograft should be left to physician choice.

    EpiFix, which became available in the United States in 2011, is considered a tissue product and is not regulated as a medical device, according to MiMedx.

    Dr. Snyder said the small sample size was a limitation of his study, as was the lack of a standard-care control group. However, he said the results show it is time for practitioners to rethink the indications for this product.

    "Many clinicians use EpiFix as a last resort, and that is not the way this product is designed to be used. It should be used if there is not 50% improvement in healing after 4 weeks of standard treatment," he said.

    The study was funded by MiMedx, the maker of EpiFix, which had no control over the study. Dr. Snyder has disclosed that he is a consultant to MiMedx but reports no other relevant financial relationships. Dr. Cole reported no relevant financial relationships.

    Int Wound J. 2014;11:122-128. Article

  • homebuilder_watcher by homebuilder_watcher May 12, 2014 1:04 PM Flag

    Will try this once more. You can go to medscape website and search for epifix in the search box in upper right side there. Amazing how difficult yahoo makes it for someone to post useful information yet it is a breeze for spammers and bots to post

  • Reply to

    $10M stock repurchase

    by volstate57 May 12, 2014 9:14 AM
    homebuilder_watcher homebuilder_watcher May 12, 2014 9:56 AM Flag

    pacora. First, they haven't done anything yet. Many companies announce buybacks and never buy any. No obligation to do so. I think they did this as a warning to shorts. There's no real impact on EPS. Do the math on a hypothetical where the company has bottom line earnings of say $50 million given the number of O/S shares and what EPS would be without a buyback and buying back 2 million shares and you will see what I mean.

  • homebuilder_watcher homebuilder_watcher May 12, 2014 8:31 AM Flag

    My institutional service shows Blackrock with 3,388,955 shares as of 3/21/14 qa change of 98,535

  • homebuilder_watcher homebuilder_watcher May 12, 2014 8:24 AM Flag

    I am only seeing an increase of 46,823 to their position?

  • homebuilder_watcher by homebuilder_watcher May 12, 2014 8:20 AM Flag

    Settlement Date Short Interest Avg Daily Share Volume Days To Cover
    4/30/2014 8,872,007 417,963 21.226776
    4/15/2014 8,994,772 612,237 14.691650

    Down slightly but days to cover up to 21 from 14 due to low volume of late

  • Reply to

    Pete's sec case

    by risicare May 9, 2014 10:24 AM
    homebuilder_watcher homebuilder_watcher May 9, 2014 1:45 PM Flag

    have heard nothing other than it is scheduled in the next 6 weeks

  • homebuilder_watcher by homebuilder_watcher May 9, 2014 9:54 AM Flag

    TRx 199 for week of 5/2 v 163 prior. NRx 142 v 120 prior week

  • homebuilder_watcher homebuilder_watcher May 9, 2014 9:34 AM Flag

    Email me if you want a copy of the opinion

  • Reply to

    where's OWT??

    by how_bout_we_talk May 7, 2014 2:38 PM
    homebuilder_watcher homebuilder_watcher May 7, 2014 3:41 PM Flag

    He's out enjoying life I'm sure. Maybe tired of a lot of the whining here lately. Like me and other long term holders , he isn't concerned about where the stock is in May of 2014

  • Reply to

    Stock action

    by scotlandabrams May 7, 2014 9:15 AM
    homebuilder_watcher homebuilder_watcher May 7, 2014 9:37 AM Flag

    Heavy volume? Wasn't it like 40% under normal volume?????

  • Reply to

    Management

    by tipsmaster May 5, 2014 1:04 PM
    homebuilder_watcher homebuilder_watcher May 6, 2014 11:11 PM Flag

    Tips, in my opinion, a year from now, you will look back at these days and laugh that you were nervous about how the stock was acting and wish you had added more. Would we rather the stock was $7 or $8 now? Sure. But for those of us that know the company well and the management of the company, our only concern is how high the ultimate selling price will be 1-2 years out. What it does right now is simply noise

  • Reply to

    Management

    by tipsmaster May 5, 2014 1:04 PM
    homebuilder_watcher homebuilder_watcher May 6, 2014 1:09 PM Flag

    tips, let me explain. The reason I suggest you sell your stock (you not others) is one of my cardinal rules of investing. That is, if you do not trust the management of a company or think they are lying (you implied that by suggesting they made up the 5X over subscribed), there is no way you should be invested in a company. I would never own a stock if I questioned the integrity of the company's top management/CEO.

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