as usual jonfraud misses my post point.
you see he has trouble with perspective and
proportionality.
the hedge fund industry is an important conduit for
capital and liquidity. ergo the industry serves a vital role
within the overall economy......
heb on the other hand has failed mankind and shareholders
yet it's senior management continues to fleece shareholder equity
for what??......a CRL and waves of lawsuits.
in conclusion, jonfraud had you paid closer attention in school
perhaps you may have overcome some of your innate
limitations and been able to recognize nuances others,
more intelligent, pick up. alas....you took the easy way out
and attempt to fake your way through life. no one that can
think is buying it.
you ultimateaszhole. SAC employees have collectively done far more good for the overall economy than the rogue actions of a few. the same can not be said for HEB.
actually in context it makes sense.....
heb trades at cash plus or minus a few pennies.
unless mr carter proves something...anything...
the cash will eventually dry up....this game is nearing an end
imnsho.
omg....jonfraud has gone crackers....
NOW he is a hedge fund manager.
i think what he is basing his half baked
strategy upon is running stops.....but
what fund is a natural long in HEB????
LOL!!!
great night....bruins just beat NY again
and jonfraud has come unhinged.
hey jonfraud, you freak, do you understand
what you are posting or is your thought proces baffling
to yourself too?????
lol....lol....LOL!!
har har har
so dopey.....you finally seem to have a cursory knowledge regarding SI reporting....good.
now chucklehead, please explain what the evil hedge fund
strategy is, given there is little "rocket fuel" left in the tank???
surely you, our class clown, are not suggesting the evil hedge fund is long..... are you??????????????????
shhhhhhh!.....jonfraud does not understand that heb should trade around cash per share. if he had a clue he'd understand that this illustrates how wrong he is on two pump points:
1) heb science(?) is priced at essentially 0.
2) even a fictitious hedge fund, based in backwoods michigan, would have covered on an opportunity cost vs waiting for zero basis long ago.
how stupid is this guy jonfraud anywho?
I'm not saying that bavituximab is guaranteed to fail its phase 3 trial in lung cancer. But without any definitive data, it's a #$%$ shoot, like most phase 2 trials run by biotech companies.
Type message Alzheimer's drug bapineuzumab is a good example of the FDA's indifference to biotech companies running phase 3 trials; Elan and its partner Wyeth started phase 3 trials for bapineuzumab before the phase 2 data was even complete.
Peregrine's investors are desperate for some validation because the bavituximab phase 2 data in lung cancer are a mess; the company doesn't know which patients got the low dose of the drug and which got the placebo.
Peregrine combined the two arms of the study and compared them to the higher dose of bavituximab, which showed an increase in overall survival of 4.4 months. Assuming the low dose was doing something, the high dose might even extend survival by more than that, but the current results aren't statistically significant.
The only way to know for sure is to run another trial. Peregrine could have run another cheaper phase 2 trial to confirm the tantalizing-but-very-dirty data from the first phase 2 trial, or it could roll the dice and jump into an expensive phase 3 trial. Don't for a second think that was the FDA's decision to make. It's Peregrine's money to spend.
Speaking of money, that seems to be the main motivator here. At the end of January, Peregrine had about $26 million in cash and equivalents. Pausing to run a second phase 2 trial would have eaten up much of that. Pressing into phase 3 trials has investors excited, which will allow the company to raise more cash at a higher valuation.
I'm not saying that bavituximab is guaranteed to fail its phase 3 trial in lung cancer. But without any definitive data, it's a #$%$ shoot, like most phase 2 trials run by biotech companies.
Biotech Companies: The FDA Doesn't Care About Your Phase 3 Trials
By Brian Orelli | More Articles
May 20, 2013 | Comments (3)
Biotech company Peregrine Pharmaceuticals (NASDAQ: PPHM ) was up as much as 33% today after announcing that it's starting a phase 3 trial for bavituximab in non-small-cell lung cancer.
You read that right. Not up 33% because its phase 3 trial was a success. Up 33% because it's starting a phase 3 trial.
Now granted, Peregrine is a small biotech company. The bump in share price only represents about a $70 million increase in Peregrine's value. But I'm not sure the news is worth even that much.
My best guess is that investors take the start of the trial as some sort of endorsement by the Food and Drug Administration. Peregrine even mentions the agency in the headline of the press release, highlighting that the company "has reached agreement with the FDA." If the agency agreed to allow Peregrine to run the trial, it must think the trial will work right?
Sorry, it doesn't really work that way.
The FDA is pretty open to biotech companies running clinical trials to test their experimental drugs, as long as there isn't a reason to think the drug will harm patients. If a biotech company can find patients willing to enter a clinical trial, the FDA is usually fine with a company running the trial. After all, that's the only way to definitively determine whether a drug works.
Examples abound where running another phase 2 trial would have made things a lot clearer, but the FDA "agreed" to allow biotech companies to run a phase 3 trial. Aeterna Zentaris (NASDAQ: AEZS ) and Keryx Biopharmaceuticals (NASDAQ: KERX ) took their colorectal cancer drug, perifosine, into a phase 3 trial based on a subset of the phase 2 data, which didn't turn out so well. Outside of cancer, Elan's (NYSE: ELN )
question: why do you never answer any questions?
answer: jonfraud...aptly named.
have you considered the results of your hedge
fund fantasy when it proves to be incorrect?
how will you interpret HEB's silence then
you chowderhead?
here is your chance to shine dopey....explain why has HEB management(?) finds it necessary to essentially dead stop earnings conference calls?
now this is a great idea for once jonfraud.
everyone, please contact the SEC as jonfraud suggests.
they have a phillie office.
tell them what you think about....management(?) communication....salary and bonuses.....jonfraud.....retreat house
.....the CRL....and all the lawsuits pending as well as those lawsuits that HEB had to settle,
terrific idea jonfraud.
go to jail for having a contrary and thus far correct opinion in a security??
24/7/365 touting of a stock is a punishable offense jonfraud. be careful what you wish for. billions in sales...white knight investors....barda....gates....tamiflu....the list goes on and on and on......
not at all....even if that was true.
i don't believe heb will commercially succeed, with years of
company supplied data as confirmation....
and i sure has hell do not believe a word you say regarding
anything heb.....your personal life, i do believe you, you're a dime a dozen.....almost parity with heb shares.
watching jonfraud losing his money and inner-credibility after his racist rants is rewarding
however, mr carter and the shamefully undistinguished HEB BOD have turned up the tempo of taking shareholder money for salary and bonuses...even with no skin in the game, that is pizzing me off. call phillie regs they are aware.
as measured by time....i can't think
of a mediocre company that has hung on as long.
why the "street" ultimateaszholos?
because AF calls it like it is??
well....that should be an easy fix even
for the unaccomplished mr carter....just conduct a conference call
and bury the "street" and all other non believers, with the dazzling
science heb has produced.
ewe....sorry my response to you was delayed. i had to run across an adult whose working vocabulary parallels that of a second grader, so i could bounce my response to you off them for understanding.
no luck.....you are a rare duck.
nonetheless, where exactly do you see words that intimidate? threaten?? or belittle? (unless provoked which YOU do all the time. i will respond to unprovoked attacks.)
if there are words or concepts i mention unfamiliar to you i'd be happy to explain in a non-judgmental manner.
ewe......i have to admit that it never ceases to amaze me when i happen upon people who don't have to believe lies, they choose to.
jonfraud and heb prey upon the hopes and desires of people.....there is no other company, or tout out there where this is as evident when viewed in its totality.
one day you will admit it...if not to all, to yourself.
retail odd lot'ers, like the recent blow-in schmell63, are what constitutes the bulk of heb bag holders at this point.
great company to keep, that breed of two-bit mutt,,,, to some i suppose.
smartin' the f up ewe. pathetic.
read up on hedge funds???
(shhhhhh.....don't want to burst jonfrauds bubble
and wake him up, but there are as many a variety of hedge funds as there has been failed, public scare spawned news cycle indications for AMP.)
jonfraud says read up on hedge funds ..... LOL!
what say this dope jonfraud read up on well run promising companies, as opposed to a perennial POS that has demonstrated no rigor in their method except in payment of salaries and bonuses.