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Cyclacel Pharmaceuticals, Inc. (CYCC) Message Board

iceman3223ice 703 posts  |  Last Activity: 1 hour 47 minutes ago Member since: Aug 6, 2004
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  • Reply to

    hindsight comment re: pilot

    by valueinvestor411 4 hours ago
    iceman3223ice iceman3223ice 1 hour 47 minutes ago Flag

    What hr is statistically significant? 15 % is pretty significant in my book. Don't remember my standard deviations. But 15% is far better than 0 percent. Are they saying because of the small sample size, 15% would simply be based on random variations?

  • Reply to

    hindsight comment re: pilot

    by valueinvestor411 4 hours ago
    iceman3223ice iceman3223ice 3 hours ago Flag

    Well then all of these issues should wash out as the study continues right? Why would dsmb have said unlikely to pass if, statistically, there is simply not enough info to judge yet because of the early deaths.

  • Reply to

    hindsight comment re: pilot

    by valueinvestor411 4 hours ago
    iceman3223ice iceman3223ice 3 hours ago Flag

    This seems so obvious as you explain. Are statisticians not consulted to design these studies.

  • iceman3223ice iceman3223ice 4 hours ago Flag

    L2l is still to shell shocked to see how bad spiro is and how he was mislead by him. He will come around eventually. We knew he was horrible at ceoing, we knew he has a flawed character, was untrustworthy, still we hoped he was brilliant in the science.. In the devastation he has left behind, it is evident the only thing he was brilliant at was padding his own pockets. If rmds has any chance whatsoever, he needs to be gone. Be glad winston, you only have an imaginary huge loss. The rest of us are really hurting

  • iceman3223ice iceman3223ice 5 hours ago Flag

    More than that, bp should have been lining up to get a hold of sap. Didn't spiro say in the broadcast that they need to reevaluate rds in the wake of the sea mess failure?

  • iceman3223ice iceman3223ice 5 hours ago Flag

    Sec won't do anything, but you a securities lawyer might. The problem of couse is cycc has limited funds for either a defense or to reimburse the massive losses here.

  • iceman3223ice iceman3223ice 22 hours ago Flag

    Mike King, Jr - JMP Securities

    And then my second question on the SEAMLESS trial. Again, we talked about this. But I forget if you're able to see the number of cycles and whether the -- given again the blinded data, whether the patients are getting the expected number of cycles so that's indicative of the tolerability and potential longer therapy?

    Judy Chiao

    Mike, we can say that because the European sites came onboard this year. So the some patients are still on. So it's not a fair thing to do to compare to U.S. patients who we have been enrolling for the previous two years, so if that’s what you meant.
    Mike King, Jr - JMP Securities

    Well, I am not sure. I just didn’t know if there was any ability, even maybe even before you opened Europe, to see if patients were getting at least two cycles of sapa and Dacogen.

    Judy Chiao

    We’ll, I think all I can say is that based on the DSMB review, whether we look at core data, the mortalities is not any different than what we would have expected on the 30-day and 60-day.
    Spiro Rombotis - President and CEO

    In other words, there is no pattern of discontinuation or [indiscernible] Mike that [Multiple Speakers] pool data. So until one have the benefit of unblinding, it's going to be hard to deduce what's going on. But there's been nothing unexpected in all the trial that has unfolded. It's pretty much according to design and has actually taken place. So, we don’t see an early gradient of withdrawal or some other kind of reason. I believe that they have ongoing as expected.
    Mike King, Jr - JMP Securities

    No, I am thinking the opposite. I am thinking that patients are getting more cycles than what we had expected. How many average cycles in DACO-016 was four if I remember correctly?
    Spiro Rombotis - President and CEO

    That’s right, it was four.
    Mike King, Jr - JMP Securities

    And then finally switch gears on 065, just wondering what additional work if any needs to be done before the IND can be dropped? And maybe you can talk a

  • Reply to

    Cycc SAP approval far more likely than market shows.

    by murdocs Dec 19, 2014 11:20 AM
    iceman3223ice iceman3223ice 23 hours ago Flag

    agreed. The market did not move one cent because of that article. I think the market has the same reaction you do to that article.

  • Reply to

    Cycc SAP approval far more likely than market shows.

    by murdocs Dec 19, 2014 11:20 AM
    iceman3223ice iceman3223ice Dec 19, 2014 3:25 PM Flag

    If we assume the best, with seamless failure
    .Spiro may have no choice but to partner..if somebody is willing.

  • Reply to

    Cycc SAP approval far more likely than market shows.

    by murdocs Dec 19, 2014 11:20 AM
    iceman3223ice iceman3223ice Dec 19, 2014 3:13 PM Flag

    I can't help thinking if they believe in the MDS results, that is exactly what they are going to. But then, why didn't they long ago when the price was only $3.00 . . unless they knew Seamless would fail and the price would be down to 70 cents??

  • Reply to

    Cycc SAP approval far more likely than market shows.

    by murdocs Dec 19, 2014 11:20 AM
    iceman3223ice iceman3223ice Dec 19, 2014 1:54 PM Flag

    RE: MDS. If that is true about the survival advantage than this is just crazy. Why is the market totally discounting MDS? As a seasoned biotech investor Due, do you have any reason other than the market simply does not believe Spiro? And if they don't believe Spiro, it is a scientifically based belief, or just a distrust of anything Spiro says?

  • iceman3223ice iceman3223ice Dec 19, 2014 12:06 PM Flag

    I guess the question is what is the definition of "expected" in this case.

  • Reply to

    Cycc SAP approval far more likely than market shows.

    by murdocs Dec 19, 2014 11:20 AM
    iceman3223ice iceman3223ice Dec 19, 2014 12:05 PM Flag

    You may be right and I hope you are, but why was this issue not considered at the time of the study design? And do we really know how sick the first enrolled patients were or are we speculating? After all, after they fail all other treatments, I would assume almost all of these patients would have been deadly ill. Do we really think there will be much of a difference in the health, on average, of the pooled participants in the study? I am trying to wrap my head around this and would like to hear more from L2L as to why he thinks this was the deciding factor. As I get it, the argument now is that SAP may work, but only after it has been taken for an extended period of time. . . is there any precedent for this type of outlook in drug administrations. I am still holding but I don't want to if this is just a rationalization that has little hope of bearing fruit.

  • iceman3223ice iceman3223ice Dec 18, 2014 11:10 PM Flag

    If so, this should show up in top line results.

  • Reply to

    CYCC Seeking Alpha Article

    by dupioneer06 Dec 18, 2014 2:56 PM
    iceman3223ice iceman3223ice Dec 18, 2014 5:54 PM Flag

    Well that's the way it always works, right? Its not just scam businesses. The CEO of Washington Mutual sends the Bank into the cellar, destroys all of the employee investments in the stock, but still gets a golden parachute of about 18 million. I am not kidding when I talk about the sociopaths, the corruption, on Wall-Street and in our government. I sometimes wished there was indeed a hell, because there are a whole lot of people who deserve to be there. For all I really know, CYCC could have been a scam since its inception with the sole intent of taking advantage of going public and fleecing investors. If that is what it intended, it sure accomplished its goal has it not?

  • Reply to

    CYCC Seeking Alpha Article

    by dupioneer06 Dec 18, 2014 2:56 PM
    iceman3223ice iceman3223ice Dec 18, 2014 5:45 PM Flag

    i.e. death spiral financing. Well then it would only be a matter of time until CYCC went bankrupt, even if Sap hit.

  • Reply to

    CYCC Seeking Alpha Article

    by dupioneer06 Dec 18, 2014 2:56 PM
    iceman3223ice iceman3223ice Dec 18, 2014 5:37 PM Flag

    I just said that . . however . . . the market is highly unlikely to give him even 50 cents right now. If BP sees no reason to buy up CYCC in the present and obtain Sap for zero dollars, the market is not going to come in and give him 50 cents per share. So this is my guess: (1) either BP buys CYCC outright in the relatively near future for cash value on the potential benefit of the pipeline or (2) we will have a reverse split within six months .. assuming the price does not go above 1 until then and (3) CYCC ekes out an existence until the end of the study. If it happens to hit, it will be rejuvinated. If not, it will simply be liquidated, after of course Spiro ensures as much of his salary he can get, and spends as much time vacationing in SF and around the world to attend medical conventions at our expense.

  • Reply to

    CYCC Seeking Alpha Article

    by dupioneer06 Dec 18, 2014 2:56 PM
    iceman3223ice iceman3223ice Dec 18, 2014 5:29 PM Flag

    Right, well I guess it can't get much worse can it? We are already trading under cash value. We will either go up on speculation about the future or down as cash is burned. What I will be curious about is whether the Market will give Spiro more money. I have significant doubts about that . . at any price. We still don't know how many shares Spiro managed to sell to Aspire before the failure, so perhaps he has a few more million in the bank than we are guessing (I have to go back to the webcast and see if cash holdings were mentioned). But I have absolutely no doubt Spiro is exploring the possibility of another secondary. I have no doubt Spiro wants to milk this for as long as possible. And I hope that somebody decides to contact a class action lawyer to go after him personally. I recognize that will hurt the company too . . but I would rather see the lawyers get money rather than spiro pocket more of our contributions.

  • http://www.thestreet.com/story/12989245/1/the-winners-for-best-and-worst-biotech-ceos-of-2014-are.html?puc=yahoo&cm_ven=YAHOO

  • Reply to

    CYCC Seeking Alpha Article

    by dupioneer06 Dec 18, 2014 2:56 PM
    iceman3223ice iceman3223ice Dec 18, 2014 5:21 PM Flag

    No, I read his piece to say virtually no chance. But even 5% chance is speculation is it not? That's why I would love to see the DSMB report . . perhaps we could come up with an actual probability rather than baseless speculation like we are all doing right now. Don't get me wrong, I would never invest in CYCC were I not already here. I decided to go down with the ship . . like the stubborn fool I am . . but so is life.

CYCC
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