pro"drugs" have been around for a while. OPKO patent is related to a pro"hormone" see Uncletlzz OPKO Due Diligence for more details
United States Patent 8,906,410
Bishop, et al. December 9, 2014
Assignee: Opko Health, Inc.
From the background information supplied by the inventors, news correspondents obtained the following quote: "The Vitamin D metabolites known as 25-hydroxyvitamin D.sub.2 and 25-hydroxyvitamin D.sub.3 (collectively referred to as '25-hydroxyvitamin D') are fat-soluble steroid prohormones to Vitamin D hormones that contribute to the maintenance of normal levels of calcium and phosphorus in the bloodstream. The prohormone 25-hydroxyvitamin D.sub.2 is produced from Vitamin D.sub.2 (ergocalciferol) and 25-hydroxyvitamin D.sub.3 is produced from Vitamin D.sub.3 (cholecalciferol) primarily by one or more enzymes located in the liver. The two prohormones also can be produced outside of the liver from Vitamin D.sub.2 and Vitamin D.sub.3 (collectively referred to as 'Vitamin D') in certain cells, such as enterocytes, which contain enzymes identical or similar to those found in the liver.
"The prohormones are further metabolized in the kidneys into potent hormones. The prohormone 25-hydroxyvitamin D.sub.2 is metabolized into a hormone known as 1.alpha.,25-dihydroxyvitamin D.sub.3; likewise, 25-hydroxyvitamin D.sub.3 is metabolized into 1.alpha.,25-dihydroxyvitamin D.sub.3 (calcitriol). Production of these hormones from the prohormones also can occur outside of the kidney in cells which contain the required enzyme(s). ...
To me it says a lot about the trade profit when a block for over $1.6M is sold at the ask bid at any time when it’s the lowest trade of the day.
my wife keeps asking me why I just can't drill for more oil since it's so plentiful?
I agree. I already crossed off the gifts I planned to buy for my family with the dividend.
that would explain why nobody seems to be able to confirm much of anything as a fact. nobody had a mobile phone with a camera?
CEO recently went on record saying the dividend would not be reduced and that "slips" in some foreign markets had already been addressed and showing a turnaround. Granted, it was on Mad Money; but he did go on record making the statements.
Natalie Kostelni, Philadelphia Business Journal, reported Novartis will acquire GSK's oncology division and Novartis will sell its vaccines, with the exception of the flu, to GSK.
The company has also been involved in deals with GlaxoSmithKline, which maintains a vast part of its North American operations in the Philadelphia area. Novartis struck an arrangement this past April with GSK to swap certain assets. As part of that deal, Novartis would acquire GSK's oncology division and Novartis would sell its vaccines, with the exception of the flu, to GSK. The two companies also decided to form a joint venture in which it would combine their respective consumer divisions.
Whether the new lease has anything to do with those transactions with GSK couldn't be determined. A Novartis spokeswoman couldn't be immediately reached for comment.
agreed. What long-term effect will that have on future SDRL contract prices? What is the average SDRL cost of producing a barrel of oil? My understanding is the Saudi price is around $10 with shale being around $80. Any info is appreciated.
correct, but nobody knows today what the future rates will be. This oil "glut" didn't happen overnight and won't change that way either. Only thing that changes that fast is the market sentiment of traders.
the chairman went on record on Mad Money after this article saying the dividend was stable. Nobody understands how long-term contracts will play out at this time.
SOURCE: Emerging Growth LLC via Market Watch
Such references as these illustrate just how little access most investors have to the potential upside of a premium rum brand taking off in the way Bacardi's Grey Goose vodka has, as the major players are either huge market cap companies with a high share price, or privately-held entities. Until recently one of the only accessible targets in the space has been Castle Brands, Inc. ROX, +5.11% which is partnered with one of the oldest rum producers in Bermuda, Gosling Brothers, whose record sales in recent years have been led by the success of their flagship Black Seal Rum brand.
MSFT sure appears to have morphed into a company that generates revenue. How do they do it?
it seems many FUDs here disregard credibility and simply post from a script prepared by some hedge fund bot. Who knows, maybe the bot is now also programmed to post directly?