I hear your point.
I wish you are right... I just dont get why they would so comfortably initiate shorts here knowing all this. There were very little shorts prior to Tuesday, and now the volume over the last few days are clearly shorts.. But again, who knows.... Either way, thanks for your info... GL
Roch will likely be interested after more data, not presently. Why and why are they shorting this so aggressively? They seem to be in full control and fearless.
I cannot phatom why this is being so heavily shorted..
and no crazy arbitrage and expiration manipulation... I love it...
ICPT concluded with a Phase II and ended the trials, meaning, Phase III was not even needed as the phase II was SO successful... You want to compare this here?? We have a long day to go baby, I am long too, but I am not banking on a $100 pop yet. I actually think we can reach $100 with a market cap of $1.5 Billion after all is said and done, but question is timing..
Agree. Sooner or later he will become old news too.... Now could be a good time for that to start, if he bashes OXGN, he will be wrong and his popularity will vanish just like Cramers'
He cant slam a $20-30M market cap... He slams companies like ARIA which are trading in the BILLIONS... What can he say, that this company, with a great and seemingly successful pipeline is not worth $50 million??
not a chance as of yet.. DO you even know what caused ICPT before you post foolish comparisons????
ICPT move was after Phase III trial ended and was a great sucess, and for a disease that millions have and no other treatments available. Please dont compare apples to oranges.. OXGN has way to go, though market cap is extremely low..
Is Avastin approved in US?
PDATE -- OXiGENE Announces Positive Topline Results From Randomized Phase 2 Study GOG186I of ZYBRESTAT(R) in Combination With Avastin(R) for Recurrent Ovarian Cancer
Trial Achieves Primary Efficacy Endpoint of a Statistically Significant Increase in Progression-Free Survival
SOUTH SAN FRANCISCO, Calif., March 11, 2014 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN), a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer, today announced positive results from a randomized Phase 2 clinical trial evaluating Avastin® (bevacizumab) with or without ZYBRESTAT® (fosbretabulin; CA4P) to treat patients with recurrent ovarian cancer. The study, known as Gynecologic Oncology Group protocol 186I, met its primary endpoint of a statistically significant increase in progression-free survival (p-value less than 0.05; hazard ratio 0.685) for the combination as compared to bevacizumab alone.
The Phase 2 study is being conducted by the GOG under the sponsorship of the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI). It is the first and currently only randomized trial to test an antiangiogenic therapeutic agent combined with a vascular disrupting agent, without including any cytotoxic chemotherapy.
"These findings validate both the novel approach and the complementary mechanisms of combining the vascular disrupting agent fosbretabulin and an antiangiogenic agent like bevacizumab in patients with ovarian cancer," said Bradley J. Monk, M.D., FACS, FACOG, principal investigator for the trial, and professor and director, Division of Gynecologic Oncology and Department of Obstetrics and Gynecology at the University of Arizona Cancer Center. "This promising combination warrants further evaluation particularly given the significant need for new treatment options in relapsed ovarian cancer."
As previously reported, the GOG protocol 186I enrolled 107 patients with platinum-sensitive and -resistant recurrent ovarian cancer at 67 clinical sites in the U.S. Patients were randomized 1:1 into one of two treatment arms: one arm received Avastin, and the second arm received Avastin plus ZYBRESTAT. Both therapies were administered intravenously every three weeks and patients were treated until disease progression or until adverse effects prohibited further therapy.
Secondary endpoints in the study include safety, objective response rate (measured according to RECIST criteria) and overall survival. Patients receiving the combination of ZYBRESTAT and Avastin achieved a higher objective response rate, which was not statistically significant. All patients will continue to be followed for overall survival. Consistent with prior clinical experience with ZYBRESTAT, patients in the combination arm experienced a higher incidence of hypertension compared to the control arm. All cases of hypertension were managed with antihypertensive treatments, as specified in the study protocol. It is expected that the full study results will be submitted for presentation at a future scientific meeting.
For this study, ZYBRESTAT is provided to CTEP under a Cooperative Research and Development Agreement (CRADA) with OXiGENE and bevacizumab is being provided as an investigational agent under a CRADA with Genentech. Bevacizumab is not approved to treat women with ovarian cancer in the U.S.; however, it is approved in other countries for treatment of ovarian cancer.
"We are very excited about these positive results and greatly appreciate all the patients who enrolled in this study and the support, resources and commitment of GOG and CTEP to conduct this important program," said Peter Langecker, M.D., Ph.D., chief executive officer of OXiGENE. "ZYBRESTAT is the first vascular disrupting agent to show a statistically significant progression-free survival benefit, and we are evaluating next steps to advance this combination to patients in need."
ZYBRESTAT (fosbretabulin tromethamine/combretastatin-A4 phosphate / CA4P) is OXiGENE's lead vascular disrupting agent (VDA) product candidate, and is currently being evaluated as a treatment for solid tumors. ZYBRESTAT exerts its antitumor effects through the validated therapeutic mechanism of tumor blood supply deprivation. By selectively affecting and disabling tumor vasculature, ZYBRESTAT reduces the blood supply necessary for tumor growth and survival. The resulting oxygen starvation and build-up of tumor metabolic by-products causes the cancer cells within the central core of the tumor to die.
I have an idea then; I hear both sides and shapion why dont you wait to short at $10? Ah, I see: so you dont see it making that far, and if it does, you would go long. I thought so..... Let the battle begin.... Cheers fellows.
Sector is hot, period.