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Incyte Corporation Message Board

jacosa 120 posts  |  Last Activity: 4 hours ago Member since: Jan 24, 2000
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  • Reply to

    Blow Away Earnigs and Upside Guidance.....

    by moenylover01 Aug 4, 2014 3:14 PM
    jacosa jacosa Aug 5, 2014 11:42 AM Flag

    You may have missed the management transition. New dog with old name, so we just don't know its character yet.

    I'm starting to be hopeful.

  • Reply to

    Regularly scheduled no-personalities CC topic

    by jacosa Jul 31, 2014 9:44 AM
    jacosa jacosa Aug 5, 2014 10:22 AM Flag

    The first Baricitinib p3 is indeed finishing up quite soon. But I don't know that Lilly will publish the result, and I don't know that any result could cause a favorable reaction. The whole set of p3-s interlock, and protection of joint structure is both the most important measure and the slowest one to demonstrate.

  • Reply to

    Stock Scam Research

    by ortensiawaitenql Aug 1, 2014 9:49 AM
    jacosa jacosa Aug 5, 2014 10:13 AM Flag

    This topic made my cat pregnant. YOU find a home for the kittens!!

  • Reply to

    Regularly scheduled no-personalities CC topic

    by jacosa Jul 31, 2014 9:44 AM
    jacosa jacosa Aug 1, 2014 11:39 AM Flag

    For once, the Zack's summary is good for something...even though it's wrong.

    We're getting this mixed price response largely because the grown ups are focused on product revenues, but everyone notices earnings. And product revenues beat pretty much every upward-revised forecast, while the net loss was a lot bigger than expected. This despite the fact that every other line item was pretty much as forecast--with one exception. Everyone, and I mean that pretty literally, expected NICE to approve marketing and pricing of Jakavi in The UK by now. If it was Incyte dealing with them, you could say "Ah Ha! Ham-handed business amateurs can't deal with sensitive regulator guys." But Novartis is doing the contacts there, and this ain't their first (or tenth) rodeo. So there's a big (relative to quarterly numbers) hole in contract revenue, and consequently a miss on earnings.

    Where Zack's goes wrong is in saying that the high YoY (but steady QoQ) SG&A number is due to commercialization activities for Jakafi. Well, maybe 'wrong' is too strong. That is absolutely what made the SG&A big in Q1 (a LOT of physician contact about dose titration and related issues). But what we're starting to see now relates to not-yet-approved uses of Ruxo (recall--trademark name should only be used for on-label use). In particular, core staff are being prepared for the push into PV [and management said as much on the call]. That mostly matters in forecasting: SG&A will increase, possibly by as much as $30MM/Q by a year from now. You double your addressable market, you increase SG&A. And if you need a fast sell-in for a drug, you generate an SG&A peak around the introduction.

    Our $60MM milestone may have to come from Italian approval (they DO get around to things, eventually). I have a sick feeling that the delay in UK may turn out to be NICE making a stand against the stupid and evil law they operate under. A by-the-rules delay here kills relatively few people; none immediately.

  • Reply to

    Regularly scheduled no-personalities CC topic

    by jacosa Jul 31, 2014 9:44 AM
    jacosa jacosa Jul 31, 2014 10:36 AM Flag

    I think Incyte is at a stage of development when sales are very important to investors. That means there are fewer bullets than you think you see. Basically, Ruxolitinib and '360. On a fundamental basis, I don't see much argument against a new "trading range" period. Jakafi for MF sets a floor. Upward pressure comes from Jakafi for PV, the possibility of Ruxo breakthroughs in non-Incyte trials and progress of Baricitinib toward market. But this is supposed to be about what we learned from the CC, and what I mostly learned was that nothing surprising is likely to happen soon.

  • Usual requests: no praise or sniping directed at other posters. There are plenty of topics to do that in.

    Little in the way of meaningful surprises. Basic financials a bit strong on Jakafi sales but otherwise pretty much as expected. Little bits of housekeeping changes in deep pipeline R&D (most important is the ocular toxicity signal in a "non-rodent" seen with the #2 JAK-1 selective candidate. This would be a total non-event except that with JAK inhibitors so new, any time a member of the class shows a signal, there's a flurry of investigation of whether it's somehow an on-target effect)

    This is the 2nd anniversary, more or less, of the "Bad conference call" and I didn't pick up anything that seemed self-destructive.

  • jacosa jacosa Jul 30, 2014 4:21 PM Flag

    The convertible bonds were taken off the table. If continuation of the company essentially as-is was the only thing being considered, there would almost for sure have been a new debt issue by now.

  • Reply to

    eraning date?

    by shawnlu2009 Jul 25, 2014 3:15 PM
    jacosa jacosa Jul 28, 2014 10:40 AM Flag

    I'm guessing that today's drop reflects disappointment that the company expects to be independent long enough to HAVE an earnings release date.

  • Reply to

    Crescendo subsidiary.

    by into_something_good Jul 27, 2014 4:26 PM
    jacosa jacosa Jul 28, 2014 10:04 AM Flag

    Well, except that while RA is life-long, it is incorrect to say that it "mainly affects the elderly." Onset of rheumatoid arthritis tends to be around 25 years younger than osteoarthritis.

  • This is only huge. FDA rarely allows results of post-facto analysis onto drug labels. Detailers can now point to the diverging curves and suggest earlier use of Jakafi in minimally-sick MF patients.

    Consider the difference: before, salespeople were only allowed to tell physicians that if they contacted the company they could get more references to clinical data. If FDA had allowed references onto the label, the salespeople could have carried reprints with them, but they'd have been on shaky ground discussing the findings. With the curves on the label, they can basically tell the whole story.

    And certain annoying people who keep saying "It only relieves symptoms" can choke on their own bile.

  • Reply to

    Big week ahead

    by maddison3 Jul 27, 2014 11:01 AM
    jacosa jacosa Jul 27, 2014 2:50 PM Flag

    #1 is hard, but just barely possible. #2 is unlikely--FDA doesn't schedule stuff for ANYONE's convenience. #3 is pretty much impossible, as Italy is on vacation and NICE, again, isn't scheduling actions for our convenience.

    Other than that, I think #s 2&3 are pretty much non-events. Europe ex-UK and IT (&ex the already onboard DE and FR) is on the same order of size as either one of those, so the rollout can keep going without them; the $60MM is modest next to the numbers that are really interesting to people. And the money question for PV is whether adding the less-serious indication can increase the dollars of sales, not whether it can be added at all.

    What (if any) sales use can be made of papers showing a MF survival benefit for Jakafi is potentially of great interest; any kind of recognition of post-facto analyses would have symbolic importance.

    There's a curious tripwire hiding somewhere--some number of country approvals of Jakavi starts up a reverse royalty to Novartis, which I don't people have front-of-mind.

  • Reply to

    sNDA was submitted in June

    by jacosa Jul 24, 2014 7:36 AM
    jacosa jacosa Jul 24, 2014 9:28 AM Flag

    Where did you come up with that one? Oh wait--you're one of those Geron noisemakers.

  • Anyone notice that part amid the noise?

  • jacosa jacosa Jul 24, 2014 6:58 AM Flag

    Small but meaningful adjustment: the control arm did 6-fold better than in RESPONSE. We don't have a "normal."

  • Reply to

    in regards to ceo comments

    by tjnelis Jul 21, 2014 12:08 PM
    jacosa jacosa Jul 21, 2014 1:10 PM Flag

    I saw 2 faults with Dr Paul as CEO. The larger one was that he was a poor public face for the company. Given that HH's biggest job was to be a good public face, it isn't fair to slam him for some happy talk that everyone else has long forgotten. (The other fault I saw was that he was in love with the IDO inhibitor to the exclusion of the rest of the pipeline)

    I have a bone to pick (preferably their C2 or C3) with the consultants who have made stock such a large part of executive compensation, but basically, you're going to see only sales, never purchases, from insiders of companies following that course.

  • Reply to

    Good and Bad

    by stonecoldfish Jul 18, 2014 4:46 PM
    jacosa jacosa Jul 20, 2014 10:45 AM Flag

    I'll assume that you are more concerned with the Class B [voting] shares. And Mr Cohen owns all of them, personally. Madison is another company which Mr Cohen controls, and it USED TO have a contract to provide business advice to EXCorp in return for an annual fee. The governing documents of the corporation dictate that both classes of stock must receive the same dividends and must share equally in proceeds from liquidation of the company.

    Over time, the management advisory fee became quite large and there were rumblings that it was effectively an improper dividend. Meanwhile, several actions that should have been subjects of advice from Madison went badly, leading to questions about whether the degree of reliance placed on that advice met a "prudent man" standard. Remember that while the board is selected by Mr Cohen, they have a fiduciary responsibility to all owners of the company.

  • Reply to

    Good and Bad

    by stonecoldfish Jul 18, 2014 4:46 PM
    jacosa jacosa Jul 18, 2014 6:10 PM Flag

    Looking backward, Mr, Rothamel can be taken as representing the "We are fundamentally retailers" approach to the pawn business, and not necessarily being comfortable with the other consumer finance businesses. Compare the tone under Mr Rotunda: embracing consumer finance and responding aggressively to attacks on the pricing structure. I'd expect the future to include fewer un-pawnshop-looking stores in nice neighborhoods.

  • Reply to

    Jakafi 2nd quarter sales estimate

    by maddison3 Jul 16, 2014 5:22 PM
    jacosa jacosa Jul 18, 2014 5:59 PM Flag

    You talk as if off label sales were a bad thing. They're sales for money, and in some ways they're even better than on-label because people either had to pay their own money or to negotiate with insurance companies.

  • Reply to


    by tjnelis Jul 16, 2014 5:17 PM
    jacosa jacosa Jul 17, 2014 8:25 PM Flag

    That would make sense except for 2 things: the first is that drug sales are structurally backloaded (doughnut hole reduces Q1 sales, while health expense accounts boost Q4); the second is that Incyte is known to lowball forecasts whenever they think they can get away with it (that was half of what got them into trouble 2 years ago). How about some read on market conditions (construed as broadly as you like)?

    I have a market condition that affects sales--every potential prescriber has now been detailed on dose titration, and it is straightforward to do as long as you're using other peoples' experience to guide you.

  • Reply to


    by tjnelis Jul 16, 2014 5:17 PM
    jacosa jacosa Jul 17, 2014 10:19 AM Flag

    All I'm really saying is don't call me out. Fight with that other guy who makes price predictions (or go away). You've predicted all 40 of the stock's last 3 down moves, often with abundant market entrails showing.

    I'll give Good TJ an opening: you've estimated below-consensus sales of Jakafi in the recent Q. Why?

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