Mounting evidence suggests an important role of cyclodextrins in providing protection in neurodegenerative disorders. Metal dyshomeostasis is reported to be a pathogenic factor in neurodegeneration because it could be responsible for damage involving oxidative stress and protein aggregation. As such, metal ions represent an effective target. To improve the metal-binding ability of cyclodextrin, we synthesized three new 8-hydroxyquinoline-cyclodextrin conjugates with difunctionalized cyclodextrins. In particular, the 3-difunctionalized regioisomer represents the first example of cyclodextrin with two pendants at the secondary rim, resulting in a promising compound. The derivatives have significant antioxidant capacity and the powerful activity in inhibiting self-induced amyloid-β aggregation seems to be led by synergistic effects of both cyclodextrin and hydroxyquinoline. Moreover, the derivatives are also able to complex metal ions and to inhibit metal-induced protein aggregation. Therefore, these compounds could have potential as therapeutic agents in diseases related to protein aggregation and metal dyshomeostasis.
I suppose if Prana submitted something on or before july 18th, but i don't think so. I was of the understanding that Price Sensitive news had to be released to the Aussie Market first. I could be wrong.
good thing Prana doesn't have to conquer- just be better than anything else out there, which in this field is very do-able. HD AD PD etc... Just yesterday another company got lauded for Maybe being able to cross the blood brain barrier, attacking misfolded proteins, and controlling tau... Sound Familiar??? It should even with a limited amount of knowledge of the science.
November 17, 2014
Abstract submission begins – AAIC & AIC
February 2, 2015
Abstract submission ends (general deadline) – AAIC & AIC
February 4, 2015
Abstract submission ends (extended ISTAART member deadline) – AAIC & AIC
Conference registration opens
March 31, 2015
Submitted program notifications sent via email
April 6, 2015
Submitted program acceptances due
April 20, 2015
Developing Topics* submission site opens – AAIC only
May 4, 2015
Developing Topics* submission site closes - AAIC only
June 6, 2015
Developing Topics* abstract notifications sent via email
July 18, 2015
Alzheimer's Imaging Consortium (AIC) – Washington, D.C., United States
July 19-23, 2015
Alzheimer's Association International Conference (AAIC) – Washington, D.C., United States
*Developing Topic abstracts will be considered for poster presentations only unless the research is considered to be late-breaking
well i think we did, hence the delay. I believe we are re-certifying with more eyes on point.