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Isis Pharmaceuticals, Inc. Message Board

jetmanbash 176 posts  |  Last Activity: 12 hours ago Member since: Dec 29, 2004
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  • jetmanbash jetmanbash 12 hours ago Flag

    Who is your jetgirl? t

  • Reply to

    What Happened?

    by topgeardel 12 hours ago
    jetmanbash jetmanbash 12 hours ago Flag

    I don't care if you went to Chicago, or Haiti. You superimpose some these bozo statements on people who are looking long term for a good investment on them like they did something wrong. Instead of being a Glad Cravits, why don't you go on about your business somewhere else. The real strong-hold for RNN is the 70 cent mark. We'll see if it hits 65 cents, but so far it has been fairly resilient at that level. You'd thing a big trader like yourself would be able to see that. t

  • jetmanbash jetmanbash 12 hours ago Flag

    It has been two decades in the making. I don't think you are qualified to make that statement/judgement. This isn't WDAY or some cloud company that hasn't been in business for very long. I would caution you in regards to shorting the stock. I believe that Oct 10th wall street will see excellent news in regards to ISIS drug for SMN.....so far there has been no further regarded "events" in regards to the patients in the studies. ISIS has a TON of new info coming along with those results and I believe the rest of the year will see more than a year's worth of good news for a normal biotech compressed into the next two months. If you have to short the stock, but send an address so that people can send you money in case you become homeless. t

  • Reply to

    If Darkout is wrong on ANS. why is he right?

    by starisontheway Sep 21, 2014 11:46 AM
    jetmanbash jetmanbash 12 hours ago Flag

    You post plenty and you distort information. Never buy a new computer or anything else for that matter because nothing will ever change, not even your prune juice brand. I hope you are actively shorting the company based on your "in-depth" knowledge and your dogmatic pronouncements. We'll see. t

  • Reply to

    Down nearly 7%!

    by wellwell579 Sep 20, 2014 10:55 AM
    jetmanbash jetmanbash Sep 21, 2014 11:36 AM Flag

    I like and find the fact that they seem to have a wide therapeutic window in regards to their drugs and that they are still seeking maximum dosages. Some of this is admittedly intution, but I do feel this company has it together as well as a small biotech can. Hope you're doing well, stay in touch, and take care, t

  • Reply to

    Down nearly 7%!

    by wellwell579 Sep 20, 2014 10:55 AM
    jetmanbash jetmanbash Sep 20, 2014 4:20 PM Flag

    Topgear knows no science. Let the shorties run around and say what they want. If this company makes it big they will be running for their lives. I myself am continuing to accumulate shares gradually. Good luck to you SMS. And bcpiii are you out there? t

  • There are many companies with much more potential than vicl. Get out before it is too late. The market place continues to speak that the company is dead meat and right now is a zombie. Make pick up some BLUE or something along those lines. But you didn't work your whole life to lose everything in word battle because you don't like ISIS. If you don't get out of vicl I'd camp out at the vicl HQ's until I could talk and spend about three hours with the conpany really grating them for info. From what I can see they are a slowly dying company and they won't be able to pull out of this. t

  • Reply to

    Down nearly 7%!

    by wellwell579 Sep 20, 2014 10:55 AM
    jetmanbash jetmanbash Sep 20, 2014 3:47 PM Flag

    I listened to the last presentation by the company and I'm even more impressed with the potental of the company and with the CEO. I wouldn't short this company to any large degree for any length of time as it seems to have extremely explosive potential to the upside. That's not to say that the company will ever make it, but the chances are very good IMO expecially when compared to comprabely priced biotechs. Also, the CEO was fairly transparent. He noted that a reverse split was possible, but that would really only be considered if they had really good news coming out and they wanted to be able to expand the potential shareholder base....with some potential shareholders held back by the extremely low share price. He also noted a possible move to the NASD to further expand that potential shareholder base. If you look at a lot of biotechs, SRPT comes to mind, they had fairly explosive share price appreciation after they had a reverse split. The thing that has held SRPT back is their reluctance to do another larger placebo controlled trial. They are trying to make it to approval with their last clinical trial and are at the mercy for the FDA as to whether or not that will be allowed in that they won't have to do another clincial trial. Also, note that their is a fairly large amount of big pharma interest in RNN's drugs. As far as the shorts wanting to make it like if they don't announce a partner right away that they are in trouble....nothing could be farther from the truth. The have $38 million in the bank, they have a burn rate of about $1 million a month...that will go up slightly in the future, and the better these drugs look in these trials the more the price goes up. t

  • Reply to

    Three large issues for RNN IMO:

    by jetmanbash Sep 20, 2014 2:46 PM
    jetmanbash jetmanbash Sep 20, 2014 2:48 PM Flag

    Part II:

    used and delivering those drugs in a more efficient and targeted manner to thus lower collateral damage from the chemo. These issues are in addition to the direct findings in the lab with their present drugs for CA which are ultimately more important over the short-term. t

  • Issue number one is some how be able to compare their delivery system that RNN has in regards to other competing companies in the RNA space. That would include RNAi and ANS companies. The trend is to use some delivery system to increase drug delivery to the target site, and decrease collateral damage via an immune response or some other untoward side-effect. The only companies that aren't actively involved in that endeavor that I'm aware of are RXII, IDRA, and maybe BPTH. Nogra also didn't use a delivery system with their primitive ANS drug that they sold to CELG. In regards to the delivery situation it is the battle of lipid nanoparticles vs. the Gal-Nac delivery systems. This battle is mostly on-going with RNAi companies. With ANS it is really just the Gal-Nac systems. The Gal-Nac seems to have taken the upper hand over the lipid nano particles. That is not to say the battle is over in regards to the lipid nano particles, but the trend is going that way for Gal-Nac delivery. We need to know how much the delivery system for RNN potentiates their delivery for their ANS drugs to know in a way their compeitiveness down the road. Second issue is how quickly they can develop new drugs for their pipeline. I'm particularly interested in ANS drug development as that is the one I'm most familar with.. ISIS with their very potent computerized model can pick out and start to develop three to five new drugs per year. Not expecting that from RNN, but that info would be nice to know as a further measuring stick in regards to the companies long-term potential(I'm here for the long-term). And finally the third big issue that would spell increased possiblility for huge success is how much interest is there by big pharma in their other delivery system(s) for more precise delivery of older generic CA drugs in being able to be revitalized with that delivery system's use. Thus hoping you'd see great deal better delivery of the older drug allowing less toxic drug to be u

  • Reply to

    Wow nycknowimstupid

    by morisretired Sep 19, 2014 8:15 PM
    jetmanbash jetmanbash Sep 19, 2014 8:28 PM Flag

    A smart vicl shareholder would have said that they sold and bought BurgerKing. t

  • jetmanbash jetmanbash Sep 19, 2014 8:25 PM Flag

    Ladies??, you might have use some xxxxxxx yourself once you really get it with the ten dollar profit. t

  • jetmanbash jetmanbash Sep 19, 2014 8:24 PM Flag

    Keep on loving it because it is going to keep on coming. I wonder if vicl does go BK, what would be your new challenger to ISIS? Would it be a big biotech to help you save face over your last fiasco??!! t

  • jetmanbash jetmanbash Sep 19, 2014 8:22 PM Flag

    ISIS has a drug out now, but the big boys are coming down the pike very soon. An interesting bet will be whether ISIS gets out one of the big boys as an approval before vicl goes bankrupt??!! I think I would take the bet that vicl will still be a zombie company before ISIS gets out one of their blockbusters, but in short order then vicl will go bye bye. t

  • jetmanbash jetmanbash Sep 19, 2014 8:20 PM Flag

    What if vicl doesn't move up by Dec.? Then will it be June 2015? The stock is down two thirds from its last highs and the stock market is up close to new highs. I heard on the VNN that they have a substantial possibility of going bankrupt. t

  • VNN rates vicl's chance for BK at 20%, and chances for reverse stock split 80%. Also, Las Vegas gaming noted that there are predicted at least three times this year where ISIS share price will move up more in one day that the whole share price value of vicl......will increase in odds as vicl approaches below a dollar in share price. Also, 90% odds that ISIS share price to exceed 44 before vicl exceeds 1.28. The whole staff at VNN wish vicl the best:))))

  • Reply to

    One baby step at a time ........

    by jimevans477 Sep 18, 2014 4:08 PM
    jetmanbash jetmanbash Sep 18, 2014 11:33 PM Flag

    More like an anaconda.....

  • Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines
    Journal of Oral Pathology & Medicine, 09/18/2014 Clinical Article

    Shin JA, et al. – The apoptotic activity of methanol extracts of Impatiens balsamina L. (MEIB) and related mechanisms in human oral squamous cell carcinoma (OSCC) cells have been systematically investigated. These results suggest that MEIB may serve as a potential drug candidate for the treatment of human OSCC.

  • Reply to

    RNN Action

    by topgeardel Sep 17, 2014 6:38 PM
    jetmanbash jetmanbash Sep 17, 2014 9:43 PM Flag

    Nothing new is being said by you either and the price remains strong with support no collapse. t

  • Reply to

    who do u believe?

    by shitakemushroom Sep 17, 2014 9:26 PM
    jetmanbash jetmanbash Sep 17, 2014 9:40 PM Flag

    Don't believe answer number one at all. t

ISIS
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