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Isis Pharmaceuticals, Inc. Message Board

jetmanbash 264 posts  |  Last Activity: 17 minutes ago Member since: Dec 29, 2004
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  • jetmanbash jetmanbash Dec 9, 2014 10:15 PM Flag

    Maybe you should put your money in CD's and you wouldn't be so jealous of anyone in the fast lane?! t

  • jetmanbash jetmanbash Dec 9, 2014 9:22 PM Flag

    It is always nice to give a little insult prior to asking a question makes the responder really respect you and want to give you the straight scoop. t

  • jetmanbash jetmanbash Dec 9, 2014 9:10 PM Flag

    Awaiting the CC tomorrow bcpiii and will comment on it after I've listened to it. Hope you are doing well, take care. t

  • Reply to

    A few things,,,

    by bcpiii Dec 5, 2014 10:45 AM
    jetmanbash jetmanbash Dec 9, 2014 9:08 PM Flag

    If I were you I'd be a superstitious investor and with all of the money you supposedly made I'd count my chickens hatched and move on. You don't have to listen to me, but I do anxiously await your same posts when the stock is much higher how this, as you term it, POS can't go above 10. t

  • Reply to

    zachs upgrade to buy

    by shitakemushroom Dec 5, 2014 7:04 AM
    jetmanbash jetmanbash Dec 9, 2014 8:59 PM Flag

    You seem to make money effortlessly, if so good for you. If in reality you aren't and are bipolar studies show that the longer you stay in a manic phase the longer you stay in the crash phase once you hit the ground:)) t

  • Reply to

    A few things,,,

    by bcpiii Dec 5, 2014 10:45 AM
    jetmanbash jetmanbash Dec 9, 2014 8:34 PM Flag

    You are using a one person study to come to your conclusion that day trading is the way to go. And that is if we can believe you that you have survived that method for making a living. The only real way for the little guy to make it is to not fall prey to the wall street diversions. The fact that you don't give a pack of gum about studies shows that you are putting yourself at an usual amount of risk. I'm not analyzing you, just asking for you to show studies that show that the regular person who day trades come out on top. I don't think they are out there because this is as you have noted rough territory. But mostly rough because the little guy tries to do what you are doing and that is "play" the market. But and hold until your target is reached after you after done your DD and that is how you can beat the big boys. And it may only take one time. The other thing you don't realize is that this is biotech. It is not Micron with chips. People are much more complicated than chips. ISIS took 20 years to make it really big, ALNY about 12 years. The thing though about biotech is that things are moving somewhat faster than they used because the half-life of innovation in biotech has passed Moore's Law in chips. To tell someone who is invested in a biotech not to pay any attention to detail in regards to what they are doing is doing a double disservice to the investor. Take a look at BLUE today.....had you shorted them based on their four patient study in regards to blood transfusion need you would be calling your mother and asking her if you could move back in with her. You thus have given bad advice IMO on two accounts. One, is you state trade the stock, two is you say don't pay any attention to the info given out by the company. For your own survival, and it may not play out here, but if you continue to root-around in biotech you are going to get burned big time somewhere down the road where you'll be calling mom....tell her I said hi BTW.

  • jetmanbash jetmanbash Dec 8, 2014 6:59 PM Flag

    Only the delirious and those who didn't take their meds think that vicl outperformed ISIS. vicl did outperform dndn though. t

  • jetmanbash jetmanbash Dec 8, 2014 6:13 PM Flag

    You should put those words to a rap song and sound angry and you could probably get some of your money back from losses on vicl. I'd change my name too, sounds too drab. Maybe MoJoGoZo would work. t

  • jetmanbash by jetmanbash Dec 8, 2014 6:00 PM Flag

    vicl down another 3 cents today and is only six cents and three mos away from pink sheet listing. Yeaaaaaa!! t

  • the that no one knows anything, and no one can get a hold of anyone. Kind of like their secret CC for "shareholders and investors" that wasn't broadcast.

    This from the vicl board where honest vicl investors are trying to figure what is going at vicl:

    iceclean10 • 14 hours ago Flag
    0users liked this postsusers disliked this posts0Reply
    Plain and simple the Colategene deal with Vical has expired.
    Vical's investor contact does not reply. May be due to lawsuits.

  • 6)Cost will be a variable that we all have to respect. The cost to bridge a patient on coumadin with Lovenox is about $700 bucks. That would be a five day supply to be dosed. If it is to be dosed with a large dose once a day it is usually around 120mg per day sq or one mg/kg sq ideal body weight twice a day if someone is willing to take two shots a day. Or in the non-renally impaired patient the dosage is 30 mg per day total. So anyone on coumadin therapy already who is going to be given bridged therapy for a total joint replacement would only really require a five day supply of Lovenox usually. So in that regard this population wouldn't be best served by trying to use ISIS FactorXI inhibitor either.

  • If I were them I'd get back to the ship and reevaluate vicl itself. The VNN reporting that vicl was down 3 cents in after hours trading. Just 9 cents and about three months away from delisting. t

  • 4)IMO I wouldn't let anyone fool you on this nonsignificant DVT/VTE business. When I was first in practice a couple of ortho surgeons said that as long as the DVT was below your knee studies showed you really didn't have too much to worry about. Things have changed IMO. The more DVT's you get, small as they are, they lead to in many cases chronic lymphedema of the lower extremities. And if you look at Virchow's laws you can see why. And IMO a Greenfield filter is of little use. People act like, "hey I have a Greenfield Filter in place and I'm protected"....really? What about those big legs that you've developed over the years ever since you had that one initial incident. Or how about the literature of the real true benefit of a Greenfield filter? Better off to prevent the DVT's and treat prophylactically than to wait till you have a really bad patient. If it was my leg and someone told me to just blow off the "little" DVT that I developed I would be pretty #$%$ off.

    5)The thrust of the research going forward for the immediate term is in regards to CKD patient's with atrial fibrillation as noted by ISIS during at least two CC's. This individual who was "reporting" was somewhat irresponsible by just sitting down on a Friday night and writing his story. Yes he is smart, and yes he is an expert in his field.....but was he really familiar with this drug and ANS in general? Was he intimately involved in the study? I doubt it. There are plenty of cardiologists out there that still don't know about juxta or Mipo. This is the perfect drug for what ISIS is looking to use it for first, that being in that specialized CKD patient with atrial fibrillation.

  • Reply to

    A few things,,,

    by bcpiii Dec 5, 2014 10:45 AM
    jetmanbash jetmanbash Dec 7, 2014 10:31 PM Flag

    Really?? Nothing stands as you tell it. The average day trader ends up losing money and gets out of the business in less than 24 months. Study after study has shown this. In fact, the average day trader that is successful really only makes about $450 bucks a day. A much more dangerous strategy, day trading on a regular basis, and you should be following your own rules in regards to wanting to be a "do-gooder." By that I mean you should be warning everyone, on every post that you are a trader and that it may be very dangerous for them to trade as you espouse. Now you might say that isn't you and you make thousands every day. In that case if you would employ that argument I would say please show me the studies that the AVERAGE day trader comes out ahead. In fact the only really way the little guy can make it is to do their own DD, study the best they can from various sources and stick with their strategy unless there is something that comes out that shows that they are on the wrong path. But the REAL REALITY is that if you really want to make it in this world you will have to assume some risk.....I don't know if you have really made, but I do know that you are assuming some/a lot of risk, probably more than the average person here with a buy and hold strategy. They are safer than you IMO compared to what you are doing here provided they follow the two most important rules, that being able to accept the risk that allows you to sleep at night, and follow the money. t

  • Reply to

    10 billion buy out -CBST---ISIS worth 8 billion -

    by amgnjim Dec 7, 2014 1:57 AM
    jetmanbash jetmanbash Dec 7, 2014 10:06 PM Flag

    I'm going to rewrite them and take out some things and repost them in a little while and see if that flies. t

  • Reply to

    10 billion buy out -CBST---ISIS worth 8 billion -

    by amgnjim Dec 7, 2014 1:57 AM
    jetmanbash jetmanbash Dec 7, 2014 9:52 PM Flag

    Yahoo keeps blocking my Part II and Part III response. t

  • Reply to

    10 billion buy out -CBST---ISIS worth 8 billion -

    by amgnjim Dec 7, 2014 1:57 AM
    jetmanbash jetmanbash Dec 7, 2014 9:25 PM Flag

    Should be part III for part III, anyway let me know what you think. Another butcher job by really professional shorts who have fed off of the gravy train for way too long. The recent rise in short interest was because uninformed shorts were waiting for another snafu. They haven't really been paying attention to what is really going on with ISIS new drugs and they were waiting for a pay check come Monday. I hope that they get pimxed badly. Take care. t

  • Reply to

    10 billion buy out -CBST---ISIS worth 8 billion -

    by amgnjim Dec 7, 2014 1:57 AM
    jetmanbash jetmanbash Dec 7, 2014 9:20 PM Flag

    It is all #$%$ Boxcar. Here is the info that I've discussed with my friends:

    1)I wonder what the definition of an ISR is here. I do know that with Lovenox about 30-40% of the time people get a big bruise at the injection site. No, technically that is not an injection site reaction because the med is acting as it should as an anticoagulant and thus technically the med is just demonstrating its action. But from a disconcerting standpoint it is significant with patients, I see it every day. So a pharm rep who is trying to sell the drug will see it that way, a patient who said the shot hurt and left this "big bruise" will see it another.

    2)The drug has not yet been promoted for going after this indication at all. It was a POC and as you noted Phase II. But if it were going after elective joint replacement surgery that would not be that big of a deal to use it compared to what that KOL said. Most orthopedic surgeons are so busy that they usually have to schedule your surgery for a joint replacement about a month out. In my state you can't get preop blood work, other testing, and medical clearance longer than one month from surgery, but I'm sure the drug could made to be given within that time frame.

    3)As far as having a 70 day time frame or somewhat longer before you see values go back to normal with Factor XI after the use of ISIS drug, as long as there isn't permanent damage in your ability to restart up the manufacturing process of Factor XI itself I don't see the big deal for this as a problem. Latest literature has been devoted to the patient who leaves the hospital and develops a postop VTE within 20 to 35 days postop after a joint replacement surgery. In fact I tell people that if they get any mysterious swelling in either leg.....even the un-operated one, or they get mysterious shortness of breath for up to six weeks after their surgery they are to report to the Emergency Dept.

  • Reply to

    10 billion buy out -CBST---ISIS worth 8 billion -

    by amgnjim Dec 7, 2014 1:57 AM
    jetmanbash jetmanbash Dec 7, 2014 10:27 AM Flag

    ISIS is worth more than $8 billion on their Factor XI inhibitor and ApoCIII inhibitors alone. t

  • Reply to

    A few things,,,

    by bcpiii Dec 5, 2014 10:45 AM
    jetmanbash jetmanbash Dec 6, 2014 5:06 PM Flag

    You've watched too much Dr. Ruth on TV with all of your analysis of everyone. The info is real, it is risky, the data coming out soon. People are all adults here and if it doesn't make it people are preparred for that. Keep trading and I hope you don't get a fat finger. t

ISIS
59.55+2.07(+3.60%)Dec 18 4:00 PMEST

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