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Isis Pharmaceuticals, Inc. Message Board

jetmanbash 427 posts  |  Last Activity: 6 hours ago Member since: Dec 29, 2004
  • Reply to

    I'm shorting this down to $20.

    by hunter249900 Dec 18, 2014 2:11 AM
    jetmanbash jetmanbash 6 hours ago Flag

    Again, as the Chinese would say, "you become very short man very soon.". t

  • jetmanbash jetmanbash 7 hours ago Flag

    I like and know OGXI very well. But I like even better the Tower of Power and that is ISIS. Their Factor XI inhibitor has the potential to be an over $12 billion dollar drug IMO. Here is the latest from Cramer on it:

    Have owned ISIS since it was $3 bucks, the potential is huge. Would urge longs here to just buy a little of it and hold for the foreseeable future. They have an SMA drug for orphan drug status, and an evolutionary drug for high triglycerides that many experts in lipidology say could become the master modulator of lipids. A one hundred share purchase five years from could be a huge investment. t

  • jetmanbash jetmanbash 7 hours ago Flag

    No he is picking out one individual stock that has a market cap below seven billion with one drug that he thinks will capture most of the $5 billion market. I believe that the market for this drug will potentially be bigger than that. First if you have 130,000 patients on renal dialysis and they are all getting this drug once a week at a cost of $16,000 per year that is $1.5 billion right there. This population has a 28 fold increase of being hospitalized compared to the general population per year for treatment of a cardiovascular event. They have a 14 fold increased chance of having a CV death compared to the general population. It would be very cost effective to use this drug to treat this population. ISIS would almost certainly get this population all to themselves because as unfair as it is this population also has an increased risk for a gastrointestinal bleed compared to the general population. It is so high that most of these patients are being under treated with aspirin alone. If look at all patients with atrial fibrillation who had a previous bleed, many of them despite an increased risk for a thromboembolic event aren't ever placed back on an anticoagulant because of risk. This population could also greatly benefit from this drug. An elective surgery patient who had time to get to a steady-state level with this drug could also benefit for low risk for thromboembolic event and yet almost no risk for a bleed. Cramer said that this drug could potentially pull in $5 billion, I say more like possibly $12 billion. t

  • Reply to

    The pump is over. Time for the dump.

    by hunter249900 Dec 17, 2014 9:53 PM
    jetmanbash jetmanbash 8 hours ago Flag

    As they say in China, "You be sad man soon." t

  • Reply to

    Cramer's Rant

    by balduscus 10 hours ago
    jetmanbash jetmanbash 8 hours ago Flag

    He is a momentum player in a 1000 areas at one time. Not many people work as hard as he does, nor do they have the experience that he has. t

  • Reply to


    by topgeardel Dec 15, 2014 12:40 PM
    jetmanbash jetmanbash Dec 16, 2014 1:00 AM Flag

    Remember DNDN is now DNDNQ. A lot of my friends would be LOL about you with your high arrogance to knowledge ratio. But stay as you are because you help make it a marketplace. t

  • Reply to


    by topgeardel Dec 15, 2014 12:40 PM
    jetmanbash jetmanbash Dec 15, 2014 6:24 PM Flag

    AMRN is going to get its tail kicked. Its fish oil isn't potent enough to treat the patients with really high triglycerides. Also, no one knows if adding more "oil", fish oil that is, could cause the high triglyceride population to develop acute pancreatitis. ISIS ApoCIII drug lowers your triglycerides by over 75%, it lowers ApoCIII by 80% and ApoCIII itself is a CV risk factor. It also lowers insulin resistance, raises you HDL......the good form of HDL by 55% and if you are a diabetic it lowers your HgbA1c by over 1.5% on average. It also causes about 2 to 10% myalgias as well. No way that AMRN is gong to be able to compete with that with their fish oil. More over I'm hearing from patients on Vascepa that starting at the beginning of the New Year many insurances will no longer cover it. t

  • Reply to


    by topgeardel Dec 15, 2014 12:40 PM
    jetmanbash jetmanbash Dec 15, 2014 5:11 PM Flag

    If you look at the biotech area In general RNN outperformed them. It outperformed many bigger known names in biotech. I don't believe you are looking at the big picture when you are making your assessment, only going along with what you hope happens. t

  • jetmanbash jetmanbash Dec 15, 2014 10:54 AM Flag

    They own 90% of all patents in ssRNAi technology, they are arguably the leader in genetic splicing, they are the leader in treating diseases that involve toxic and also repeating RNA, and they are undoubtedly the leader in ANS. Because they are the leader in RNA technology they have also become the leader in LICA delivery and are doing well in competing in the Gal-Nac space as well. And finally they will become IMO the leader In orphan drugs because of all of the above. They also because of this IMO lead the world in Huntington's disease, and ALS. t

  • jetmanbash jetmanbash Dec 13, 2014 6:30 PM Flag

    A big difference and your posts aren't arrogant compared to brand X. t

  • Reply to

    Decent day for worst day of the year.

    by aheitt2020 Dec 12, 2014 5:09 PM
    jetmanbash jetmanbash Dec 12, 2014 8:29 PM Flag

    Hey KG, good to have you here. Take a look at SCMP too. Hope to see you and G over the Holidays. t

  • Reply to

    Back She Comes

    by hbacon_99 Dec 12, 2014 2:34 PM
    jetmanbash jetmanbash Dec 12, 2014 8:24 PM Flag

    NO that is your version English teacher with superimposed jealous and hope that it tanks with no realization at all of the POSSIBILITY of something big happening here. And the lack of at least thinking that the line at 70 cents shows that the stock won't be moved down easily from that level based on the risk situation being in balance there. Unlike the cow who keeps thinking it is going to 39 cents. t

  • Reply to

    just one question

    by adel7 Dec 9, 2014 11:57 AM
    jetmanbash jetmanbash Dec 12, 2014 12:24 AM Flag

    Their antibiotic has a really good chance to be a really important drug. It is considered a neo-aminoglycoside. Drugs in that same family are gentamycin, tobramycin, along with some other older antiobiotics. They have still had great importance. The difference between this drug and those is that this drug will probably have broader antibiotic coverage. And unlike the older aminoglycosides this drug does not have any risk for oto-toxicity, and renal toxicity.

  • jetmanbash jetmanbash Dec 11, 2014 11:09 PM Flag

    You are the real psuedo-wanna-be English teacher always correcting everyone here. t

  • Reply to

    Just For Fun

    by topgeardel Dec 9, 2014 10:58 PM
    jetmanbash jetmanbash Dec 11, 2014 11:08 PM Flag

    You are the degrading person who accuses others of arrogance while dishing it out in dump trucks full. You seem to be the English teacher trying to teach everyone your "way." And in a nonhumble way I might add. Trading all the time going up against the big boys, paying commissions in, commissions out, short term gain tax, keeping tons of records. There was a guy on the ISIS board named sourdough who was like you, bragged a lot like you too. Everyone that I know and have known for a long time out did him in regards to their ISIS investment while he was a slave to the screen and made all of those payments and kept all of those records. Now everyone there has really outperformed and have less tax liability. Or are you one of those guys on TV at the discount brokeage firms where you buy and sell with no attention to what happens and the money just rolls in? t

  • Reply to

    Darkout -- it has been nine years

    by dogsdazed Dec 11, 2014 9:35 PM
    jetmanbash jetmanbash Dec 11, 2014 10:37 PM Flag

    Agree Dog, Dark is not a terrible person at all. And he is also very sharp as a person. He would however IMO be best able to serve himself and Man/Womankind by doing something different such as teaching little kids to read, or anything that would really make the world a better place. Also, I don't think he could invest in ISIS. t

  • jetmanbash jetmanbash Dec 11, 2014 10:55 AM Flag

    If the data continues to look good that time frame could work out perfectly in regards to their clinical trials coming out with results. t

  • Reply to

    Just For Fun

    by topgeardel Dec 9, 2014 10:58 PM
    jetmanbash jetmanbash Dec 11, 2014 12:43 AM Flag

    You really are one arrogant dude. Most of us here are little people looking for a good stock. Thank you so much about thinking about a flannel board. t

  • jetmanbash jetmanbash Dec 10, 2014 10:20 PM Flag

    You take care Dark, and look into RNN. t

  • Reply to

    A few things,,,

    by bcpiii Dec 5, 2014 10:45 AM
    jetmanbash jetmanbash Dec 9, 2014 10:22 PM Flag

    Self declared victory by the board Napoleon with a one person study that can't be verified no doubt. How about posting your trades in real time so everyone can see how tall Napoleon really is? t

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