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Isis Pharmaceuticals, Inc. Message Board

jetmanbash 4745 posts  |  Last Activity: 10 hours ago Member since: Dec 29, 2004
  • jetmanbash jetmanbash 10 hours ago Flag

    I'd take my lumps, sell early and move onto MSTX in you are interested in CHF treatments. t

  • Reply to

    Big dates ahead,,,,

    by bcpiii 23 hours ago
    jetmanbash jetmanbash 14 hours ago Flag

    Apparently this Tricia in IR from the Trout Group is on maternity leave. Will try to call in am and see who I get. t

  • Reply to

    Big dates ahead,,,,

    by bcpiii 23 hours ago
    jetmanbash jetmanbash 15 hours ago Flag

    I haven't, I'm going to again try and call IR and see if I can talk to anyone in regards to this and several subjects. With what has happened to CAR-T1 drugs in regards to solid tumors where that was a big let down, if this company's mission statement can come true in regards to their drugs with solid tumors we could see some :CAR-T1 like action" share price-wise with this stock. t

  • Wow, The Journal of Lipidology has an article about one patient on Juxtapid.......what an adventure:

    The lady took a couple of days of cough syrup and Tylenol and her liver enzymes went up 16 fold. She had trouble controlling her coumadin dosing, had a couple of small strokes......and the myth about less needle sticks all things considered could not possibly be further from the truth. The extremely low and volatile levels of Vitamin E would worry me for hearing damage long term.

    This is a very troublesome drug IMO and there is no real life data two years out that shows reduction in CV events. Like this article notes, the liver enzymes shot up for whatever reason. This juxtapid should not be used with coumadin IMO at all either. The competitor has shown and eight fold reduction in CV events over the two year post release real life data.....not seen with this drug juxtapid. In fact part of this article notes the patient hospitalized and discovered to have two small new CVA's. When you add up the dosing changes up and down, and the blood draws to monitor the drug because of this with liver enzymes and the watching for vitamin deficiencies net-net I'd bet there are way more needle sticks with this drug than with the competitor. And liver safety-wise a recent liver biopsy of patients on the competitor, six patients, showed NO liver problems after two years of real world use. t

  • Reply to

    Big dates ahead,,,,

    by bcpiii 23 hours ago
    jetmanbash jetmanbash 20 hours ago Flag

    I am anxious to hear what they have to say on both of those dates. If I can listen to the reports myself I'll post thoughts associated with that. I wanted to go to the annual meeting on June4th but have a conference I have to go to on June 3rd but will follow events as close as possible. Thank you for posting the dates. t

  • jetmanbash jetmanbash 20 hours ago Flag

    vaccinesaregoodexceptvicls, Chum you are making yourself look bad in not knowing the difference between a small molecule and an oligonucleotide RNA medication. That's OK, I forgive you. You need to go back and start throwing around the words prune juice and prune head to gear us up for big gains in the am. I hope and think we've solved your water problem with the tears after looking at the vicl chart every day. Now we have to find a way to cloth you Chums once you get out on the commune. I'd start right now in trying to develop cloths made of worm skin. You could then have your worm farms, your worm meat, and then worm cloths. If you Chums could pull that off and sell vicl while you still have some money left I think the commune will be a free-standing environment. That darn vicl has brain washed you you chums. Maybe if our bet comes through with ISIS at a 70:1 ratio by the 4th of July you Chums will see the light. t

  • Reply to

    I OWN THIS COMPANY!!!!!!!!!!!!!!!

    by herdergoat Apr 25, 2015 6:46 PM
    jetmanbash jetmanbash Apr 25, 2015 7:18 PM Flag

    I sure hope that you are a paid basher as I don't see how you are employable otherwise. Good luck to you though. Just ask that you remain as dramatic as you lose big money. Kind of like the GEICO lizard when he has a flat tire. t

  • Reply to


    by whiterain101 Apr 25, 2015 3:12 PM
    jetmanbash jetmanbash Apr 25, 2015 3:51 PM Flag

    I think an added new discovery. Triple negarive breast CA is one of the hardest to treat and the documented stopping of metastasis makes me think that this drug could be added to any and all breast CA treatment cocktails to stop mestatasis. We just have to be patient there is huge potential out there for us. A lot of market manipulators out there and the market always makes it so that the least amount of people are happy with how they played their cards when in situations like this. t

  • jetmanbash jetmanbash Apr 25, 2015 3:31 PM Flag

    vaccinesgoodexceptforvicls, No I feel very well thank you. I would point out to the neutral parties to go and check and see that you Chums that used to take weekends off are posting here all through the weekends to try and get your hateful message out. Take is again OK in my book because you or one of the Chums will invariably mention the magic words and we will be propelled higher next week. So thank you again for helping to make my friends and family notably richer. You guys are the best. If I were you Chums I would settle out in the Nevada desert somewhere. No state tax and you guys could get land relatively cheap there. You just need to find a way to get water. If you had all of the Chums look at a chart of vicl everyday, collected the tears, desalinated them, and purified them you Chums might be able to supply most of your own water needs. t

  • Reply to

    Proxy Vote

    by tommer1024 Apr 25, 2015 7:02 AM
    jetmanbash jetmanbash Apr 25, 2015 3:07 PM Flag

    I agree bcp. I look for them to really be successful. It is an unusal situation that their drugs have been so safe that it is taking an extra long time to find out the baseline toxic dose. If this is coupled with real CA treatment qualities I believe that these drugs could outperform the CAR-T1's. This would be especially true if the company could show wall street that they have a unique way for developing CA drugs that do not cause collateral damage. Looking forward to this summer. Hope you are doing well, t

  • Reply to

    CEO search

    by dj111177 Apr 25, 2015 9:18 AM
    jetmanbash jetmanbash Apr 25, 2015 3:01 PM Flag

    You know this drug could really put OPK up there in regards to respect and sales. OPK isn't doing that bad anyway. Dr. Frost is unique in that I've never seen a CEO buy shares of their own company like he has been doing. t

  • jetmanbash jetmanbash Apr 24, 2015 10:56 PM Flag

    As long as this is Paul Bunyon tall tales day, I bought 100K shares of GOOG at $65. t

  • jetmanbash jetmanbash Apr 24, 2015 10:54 PM Flag

    See you don't know the difference about anything mr. dogface. Vioxx is a small molecule, also mr. dogface, Vioxx is still sold in many places around the world. In good part its demise here relates to the legal environment that will hit vicl in two places. One will bad vaccines, and two will be the lawsuits where lawyers go after vj after another year of being the worst CEO in biotech. t

  • Reply to

    News is good, why down?

    by system_architect_enterprise Apr 24, 2015 12:34 PM
    jetmanbash jetmanbash Apr 24, 2015 10:52 PM Flag

    Dogface, You would do your cause better by learning more about vicl and telling those on the vicl board about that info. I know it won't happen, and I know that to be the case as there isn't any info coming from the vicl board that is important and thus you stay over here. You and the Chums will be jealous, cold, and broke come winter. I urge you to sell vicl and buy ISIS now. t

  • Reply to

    News is good, why down?

    by system_architect_enterprise Apr 24, 2015 12:34 PM
    jetmanbash jetmanbash Apr 24, 2015 10:48 PM Flag

    Nj, you and the Chums are basically jealous. And you know what that is OK. But your biggest weakness is that you don't know anything and you haven't kept up with any knowledge you just have hate. You have been a blessing here because of two things. The reverse VooDoo cheerleading, and any new interested but uninformed investors just see the same thing that comes out of you and the Chum's mouths. Like you know that asbestos is a good fire retardant but you haven't kept up on the fact that it is no good. Kind of like vicl is no good. A couple of Chums bad mouthed AGEN before so I find it hard to believe that the Chums have embraced it. In any case, thank you again for the prune juice/prune head chant to your Jamaican gods for the benefit of all longs here as they are all getting rich. t

  • jetmanbash jetmanbash Apr 24, 2015 7:58 PM Flag

    A list of the "boys" that didn't do well this week:

    Healthcare: AMPE (2.73 -65.31%), AERI (12.87 -62.31%), CALA (13.41 -27%), SPNC (26.52 -23.62%), ASMB (15.46 -21.03%), CLDN (13.68 -17.22%), CPRX (3.69 -16.14%), PTX (7.09 -15.09%)

  • Reply to

    Question about MSTX

    by mundomayagold Apr 24, 2015 8:10 AM
    jetmanbash jetmanbash Apr 24, 2015 7:57 PM Flag

    Both their CHF and sickle cell anemia data look good. I do know that a good part of the CHF data is coming out of Beaumont in Detroit. t

  • AGEN +1.9% (announces the final results from the Phase 3 study of GlaxoSmithKline's (GSK) candidate, RTS,S, demonstrated a statistically significant reduction against malaria in children),

  • jetmanbash jetmanbash Apr 24, 2015 8:25 AM Flag

    That should have been VICL, but there is nothing left to crash. Chums sell that garbage and fire tudywad, vaccinesgoodexceptvicls and move on to the commune before it is too late. t

  • it will a continued spiral downward. Nothing there, they got an extremely small amount that the Chums would have made fun of if ISIS had received that low of number. I wish the Chums themselves could have gotten it so they could get somewhere better to live. Not a fair world Chums, don't get cut with the double edged sword.....sell vicl and buy ISIS. t

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