No the ADXS platform is not presently tailored to individual tumor genes in individual people. To take a tumor cell remove it, bio-engineer it and return it to each individual patient is prohibitively expensive and time consuming That is why Dendreon is going bankrupt. The Advaxis listeria platform is inexpensive, and production is higly scaleable w quick turnaround time. Yes all cancers have individual genomes but they also have common traits by types such as proteins, enzymes, kinases and checkpoint inhibitors. So far the Advaxis flagship product has been proven to aggressively attack HER2 positive genotypes which affects a very significant % of the overall population. Roche/Genentech/Immunogen's monoclonal antibody Kadcyla for example is now becoming the standard of care in breast cancer where the patient is HER2 positive, which is determined quickly by testing the patient, not the tumor. Sales of this drug for this one indication are running around $3billion annually. By combining Advaxis' off the shelf product w Merck's checkpoint inhibitor Keytruda, you could get as near as I can determine a 2X-3X increase in T, NK cell activity and tumor response rate. This is a very big deal. There is no question in my mind that the course Advaxis is on is the right way to go. Look for a buy-out within 2 years @ 20-25 per share, maybe more.
It's speaks to Dan's long term vision for Advaxis and his passion and work ethic that he has been able to put together a team of the truly best and brightest in immuno oncology. I would say Advaxis is a frontrunner now and on the way to becoming a force. Probably be a cash raise next quarter. I'm ok with it- they're earning it step by step. Off thread a bit- anybody with some idle cash may want to buy some AKER ahead of what I believe will be a very big announcement. Company is developing a field use 5 minute finger #$%$ antibody/chromatograph test for the Ebola antibody. 97% predictive. Could be ready to ship by end of November. Stock is thin, company is growing fast with other rapid diagnostics and should be profitable in 2015 without Ebola test.
Very interesting. In light of the fact that the company should be EBITDA positive w DuraFit in 2015, it's unlikely that they will need to sell any more stock- unless they want to fast track commercial development of Spinel. So the value of the existing available shares increases. My guess is whoever bought the offering added some more this morning and may in fact be interested in a 13D stake. The single biggest problem with car/truck emissions control is the cost of the catalytic converter-pretty much everybody that owns a 100K+car or works on cars or smogs certificates cars has a catalytic converter gripe or eventually will. I did a quickie patent search- found the PGM from 2013 but not the new ones. If the IP is legit, this company and it's stockholders will be MAJOR winners.
He has misled investors about GIG's prospects for 5 years, refused to conform to GAAP metrics in a hardware business where everyone else reputable does. And he has back-doored cash and cash from stock at every opportunity. He has probably put on his cleanest underwear and brushed his hair, and stifled his neurotic Hebrew accent to appear as attractive as possible to GSIT directors and the cash hoard on which they sit. . I'm not goin' for it and neither are the Asians.
As a retired analyst- retired because I was good and made a lot of money, I would remind you fbg that you never want to compare your valuation to a company that is overvalued. The overvalued usually comes down. That said, the market cap for Advaxis could be 500 mil or perhaps more in 24 months assuming the data for the Keytruda/Advaxis combination is compelling, which the scientists believe it will be. I think enough data will be available in 16-24 months to make Advaxis a hot buyout candidate. If I am one of Bristol Myers, Astra Zeneca or Merck and I have a PD1 candidate the efficacy of which is signicantly enhanced by combining it w Advaxis I am going to try to buy the company before the other two do. This could be really good for Advaxis and could take the take out market cap much higher.
I would bet dollars to doughnuts, second thought, I bought a doughnut for $2 yesterday- anyway you get the idea. that the "investor", with whom this whole pump and dump was prior orchestrated, sold short 168,000 shares somewhere above 3.50 the day of "the PR Release" and then used the 1cent warrants grant to cover them- an immediate profit of 100grand. It's illegal of course, but it happens quite a bit. The director leaving at the same time no coincidence. A director to replace him from a mining company in Nevada w a less than stellar record of corporate governance also no coincidence. The Spinel technology, according to Lambert who has more school and papers on the subject than all the CDTI management combined, the amount of rhodium, palladium, platinum in catalytic converters is only about .5% and nothing including zirconium, lead, magnesium will convert NOX3- . Had the company run a profitable business, kept it's neck out of a noose, I would be inclined to take a wait and see approach on a new catalytic converter technology, despite the fact that the best organic chemists and automotive engineers in the world have been working on it fruitlessly for 30 years. But given the company's record, their human resources, and the tendency to overpromise to investors with extra checkbooks when people are chasing "story" stocks, I have a feeling this is not going to work out for retail investors.
The tank division I believe is the one division that has had tremendous growth prospects and opportunities, squandered by the ineptitude of Art's Way's business development/marketing not to mention inattention to the manufacturing process. Think about it. Natural gas, LNG, CNG industries have tripled in production and storage capacity past decade, and the water and process industries have also been healthy. Art's Way hasn't done jack. They're sitting on their butts, they're not competing. They're aggressive in pursuing acquisitions but they are not aggressive in operating and growing them. Look at all the Ebola treatment/ quarantine centers they could be supplying. They got their heads up they're butts there in Davenport.
They're getting way ahead of themselves saying airlines will go too far in adding capacity and that the oil price drop will be fleeting. Low oil 75-90 is here to stay. The U.S. is producing 9mil BPD and Canada 4.5 from existing developed shale fields- twice what they were producing just 5 years ago against a use rate of 19millionBPD that is stagnant to declining. This is a long term trend, not a blip. While it is true that shale wells have high decline rates, it's fairly easy and cheap to tie 15-25 of them into a single hub, and the supply of shale from already active deposits has an aggregate cost basis with current extraction methods of $40-45 per barrel so even at 75 everybody is making a good living and nobody shuts down. Who will shut down is subsalt, deepwater offshore and energy and labor intensive onshore- some of the tarsands. This may effect EXXON and ROYAL DUTCH and STATOIL AND PETROBRAS investments and developments. The supply demand situation will remain in parity around 80-85. And what is "too little too late"? One would think any self-respecting analyst, excuse the oxymoron, would reach a little further into Roget's to find a less abused cliche. I am a retired analyst and I became one because I wasn't judged good enough in math to be an engineer or good enough in English to be a writer, but If I were trying to hide that I was trying to influence the market on behalf of a hedge fund client who is stuck short with Jet Blue I would come up with something better. JetBlue is a good little company and they are growing rapidly and sustainable, IMO. I upgrade the stock to a Strong Buy with an $18-20 12 month target. People are flying again. It's a social phenomenon that is here to stay for the foreseeable future.
I showed it to a guy from Cal Tech who is automotive engineer in Fremont. He used to work for Toyota and now works for Tesla.. He says "no way". Only rhodium will catalyze nitrogen oxide. He said at best this design may work for a few thousand miles and then "load up" and have to be replaced or recharged. Like I said the unnamed "investor" who shorted the stock on the "disruptive" press release and then was granted free warrants at a lower price to cover made a hundred grand up front and can afford to right off a big loss on the rest of it against income for tax purposes..
You're an idiot and you're manic- bad combination and peculiarly ironic to be on this message board. Hopefully, MDX will become available to you
Listed exclusively on Nasdaq where the IPO was executed. There are some institutional owners who took positions before the IPO and added more in the IPO itself, including some very smart venture capital money managers from Israel. The original lock-ups have long since expired- these guys could have sold 26 and none of them did as far as I know. Tells you something. It is my understanding that today was the first day that management got to evaluate the unblinded data. The fact that the stock was up strong all day- even in a mostly down market also tells you something. Not sure when the news will be released. Could be tomorrow, could be Monday..
The stock of every company even peripherally involved in Ebola treatement containment is on fire. Lakeland Industries which makes HazMat suits and has been losing money has tripled their share price in the past month and gone from 8 to 20 this week alone. An investor- Frontier something or other was insistent on drawing out Majeskie- since Palmer was on the road- about bio-containment. She and Mack Sr. seemed a little uneducated to the opportunity and the investor didn't really ask insightful questions. When he asked about domestic quarantining or treatment facilities Carrie answered off the cuff that it may require individuated HVAC systems, but it doesn't. People show up -in Africa- tens of thousands per day to tents and makeshift huts - with some symptoms- fever, diarhhea, headache, fatigue . Caregivers in gloves and masks ask questions, take tests and park them, give them IV fluids and park them if they have the space or send them out. The danger in transmission is in body fluids, not in air. Whatever body fluids are generated at present, remain on the premises as new visitors come and go and the patients if they require observation or treatment are housed in a squalid, overheated, and undersanitized environment. If Art's Way set up a single Ultraviolet or silver ion filter in the HVAC system all the airborne bacteria/ viruses would be killed in the entire module. And of course because the surfaces are sanitary and easily flushed, the problems with body fluid transmission could be greatly reduced- the stalls could be open or screened for privacy. And bio-testing, diagnostics could be done in the module or preferably in a separate module in a cluster of modules. I believe every town in West Africa w a pop over 100,000 should have a campus. Maybe 20 intake screening and treatment/ quarantining modules and a lab module. Come on guys, get off your butts and help save the world
No doubt. Spana will be out playing golf and buying a new BMW on some poor sucker's rent money. He's going to play this game until somebody shoots him or the last sucker is broke whichever comes first. Sex drugs are BS. EIther you have it or you don't. If you don't and you want it- do the work. If you're looking for a quick fix, you will pay the price in cardiovascular events, headaches, vision, you'll be on that big pharma Western medicine merry go round that ends in premature death
Tesla was IPO'd specifically as a start-up with the intention of making a truly new automobile. Clean Diesel was an already public shell w an ongoing, if somewhat unexciting business. That original business as well as the people who ran it thru various iterations are in the history books. Think of it going forward as a start-up. There is a name change- a re-branding if you will- in the works, and what happened the past 4 years will be just a prologue in a very new book.
Look, I'm a marine biologist- I set up live reef sytems for people like Michael Bloomberg and I asked a client who runs a very successful hedge fund and graduated from UC as a chemical engineer to check this out for me.. He came back and said the technology seems to be an "exciting breakthrough" , that post loan amendment the company has enough cash to begin the Spinel commercialization stage. He listened to the conference call , said the CEO and CFO seemed "on the ball" He is prohibitied from buying microcaps for his clients, but he bought some for his own account yesterday and so did I. Gotta go DB, gotta get back to work.
The short interest is low. Nobody with any substantial net worth- fund or individual shorts this stock- which leaves the shorter profile to dilettantes and small potatos gamblers- with the exception of perhaps a hedger like a note holder to protect against a default. After this week's loan term amendment to 2016 those positions would most likely be covered and not be reinitiated until a spike in price/ due date approach.
It's not a pump and dump. There is some pumping- necessary to gain traction for a transformative technology in a huge, slow-moving industry. There's no dumping. I don't really see it as any different from Tesla. Most folks scoffed the first couple of years when Elon Musk was telling everybody they were going to fundamentally advance the automobile industry and they were raising money. The scale of course is different w CDTI at this point but the premise of disruptive technology in the automobile industry is the same. I remember when Mr. Toyota- the CEO himself came to S.F. and Elon took him for a ride in a prototype Model S. The next thing you know, Toyota wrote a check for $50million and signed over the Fremont production plant which had been producing Toyotas to Elon to produce Teslas. Something similar will happen here, wait and see.
Short positions have been building big the past few months just like short interest on the Airlines spiked right before 9/11 and it was proven after a determined effort by forensic accounting investigators that the Saudis had been using offshore decoy accounts to do it. I say blow the towelheads up! They talk outta both sides of their mouth and cannot be trusted AT ALL.
For $100 you can subpoena a shareholder's list and initiate a procedure to replace the board of directors with a new slate that will be less committed to nespotic management and more committed to increasing shareholder value.