I don't think shareholders of Citigroup, Sears, Freeport McMoran, Peabody Energy, Blackberry, AMD, etc are sharing your sentiments. It's called sector selection. Pick best of breed in the right sectors and you will do well over the long term regardless of euphoric bubbles.
Daviscupper, I remember you from the debacle of 1/30/13 when all hope was lost. Huge expectations were dashed. I did balance the downward spiral with ACAD holding from 1.80 to present day 30s+. Also, HALO, ISIS, SAGE and TROV have been very good winners to hold . Do you think our beloved, but battered Celsion has a good run left in her or is it an exercise in futility?