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Prana Biotechnology Limited Message Board

kadaicher1 16 posts  |  Last Activity: 1 hour 36 minutes ago Member since: Jan 23, 2004
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  • kadaicher1 kadaicher1 1 hour 36 minutes ago Flag

    Maybe now is the only opportunity we will get to negotiate some concessions from Syria and Hamas. That opportunity is being lost. It is doubtful Israel will ever give the strategic Golan Heights back to Syria. Now is the time to cut a deal, with half of Syria under serious threat of being lost. Makes the Golan Heights look pretty small. Working with the only countries capable of a credible fight, Syria and Iran, success may be assured without putting US troops on the ground.

  • kadaicher1 kadaicher1 3 hours ago Flag

    Not sure there is a lot of choice. Pre 9 11 the US had saved Muslims in Kuwait and more so in Kosovo facing genocide. Maybe the US is attacked more for what hey are, leaders of the free world.

  • kadaicher1 kadaicher1 3 hours ago Flag

    I don't think he is wrong to bomb ISIS in Syria, but I think there is perhaps a flaw in his final objective, which I think is to destroy Assad. They took out the strong men in Iraq and Libya and look how that worked out. For that matter the US and Britain were behind the removal of the Shah. Also a big mistake.
    He needs to talk to Assad and work with him for now.

  • Reply to

    0barna. lame duck war mongrel.

    by fabulous_pucks 3 hours ago
    kadaicher1 kadaicher1 3 hours ago Flag

    I think he could do a lot of damage if he takes out the strong man Assad. If the efforts to get rid of Assad had worked ISIS would be very much stronger, and maybe in control of Syria. The only country that successfully resisted ISIS is Syria. Take out Assad and all is lost. Is that Obama's plan.
    The Syrian Christians have backed Assad. They live there . Now we have the US shaping up to wipe out the Christians and Alahwites by arming so called moderates who will odds on go with ISIS. That is very dumb and depressing.

  • kadaicher1 kadaicher1 Sep 8, 2014 12:33 PM Flag

    Yes it is not too far away. Orphan drug was was a first step, and with a HD trials expert on board we are ready to run.

    Sentiment: Strong Buy

  • Reply to

    $4's

    by pharmaheromillionaire Sep 8, 2014 11:00 AM
    kadaicher1 kadaicher1 Sep 8, 2014 12:24 PM Flag

    If you are right there is hope on the horizon for HD patients. If they are successful they can pass ACAD, but they need some results. The new trial is bound to be aimed at the most likely patient group to gain benefit. Identifying that group is really all the Reach2HD trial was about. Of course we all wanted it to hit a home run, but I will take what they got.

    Sentiment: Strong Buy

  • kadaicher1 kadaicher1 Sep 8, 2014 12:17 PM Flag

    If I remember correctly PFE are one of the sponsors of the AIBL study. I am sure they know all about PBT2 and may be ready to make a move. PFE may be looking at the extension data with interest.
    I agree Prana are probably talking with several pharmas.
    I guess Prana can talk to anyone they like about the extension as it is no longer blinded.

    Sentiment: Strong Buy

  • kadaicher1 kadaicher1 Sep 8, 2014 12:09 PM Flag

    Thanks for that pierreluke. I think they are going to move on this HD trial very soon. I hope they are going after very early stage disease and even slightly pre onset. The last trial left little doubt in my mind they could succeed in that patient group. Docs can now predict onset with some accuracy if people get tested.
    This is going to be big news.

    Sentiment: Strong Buy

  • Reply to

    Good buying opportunity!

    by resource405 Aug 6, 2014 9:21 AM
    kadaicher1 kadaicher1 Aug 7, 2014 2:25 PM Flag

    You could be right, but they would need to show some signal in the extension trial. Maybe an aggressive Parkinson's program could do it.

    Sentiment: Strong Buy

  • Reply to

    Tau Joins APP in the Ironworks

    by interestingtome Aug 4, 2014 2:05 PM
    kadaicher1 kadaicher1 Aug 7, 2014 2:21 PM Flag

    Finkelstein has his own synaptic lab at the Florey. Ashley Bush is the head of the oxidization lab, Cherny is his deputy and Adlard is a senior research fellow at the same lab. Masters is division head.
    Combined with strong links to the labs at Harvard, there is some powerful research muscle driving this small company.
    Nice posts interestingtome, thanks.

    Sentiment: Strong Buy

  • Reply to

    Tau Joins APP in the Ironworks

    by interestingtome Aug 4, 2014 2:05 PM
    kadaicher1 kadaicher1 Aug 5, 2014 11:56 PM Flag

    Bush has backed his statement with some elegant research, whereas your statement is truly stupid, implying everything is already known about these processes.
    (Now, Bush and colleagues have discovered that samples of human brain tissue affected by Parkinson's disease contain lower levels of soluble tau but elevated levels of iron. This lack of tau protein, they suggest, could increase iron levels in the brain and cause neurodegeneration.

    The team tested what happened to transgenic mice without the tau gene. They found that at 12 months old the mice were cognitively impaired in a maze test and there was severe degeneration in the cortex and substantia nigra regions of the brain - the areas typically affected in Alzheimer's and Parkinson's, respectively. What's more, they observed that iron accumulated in these regions.

    When the team put 6 and half month old tau knockout (KO) mice on a diet containing the drug clioquinol, a non-toxic iron chelator, they found it halted iron accumulation in the affected tissue and completely rescued cognitive and pathological degeneration, providing evidence that iron causes neurodegeneration.

    'Treating a tau KO mouse with an iron chelator was not an experiment you would have predicted to be obvious from the existing literature,' says Bush. 'We were quite stunned by how profoundly clioquinol rescued the tau KO mice.' A further experiment revealed that a lack of tau impairs the trafficking of a protein involved in neuronal iron export.)

    Sentiment: Strong Buy

  • Reply to

    So what happens if...

    by daniel.kiely Aug 3, 2014 11:12 AM
    kadaicher1 kadaicher1 Aug 3, 2014 12:07 PM Flag

    That is the point, if they can win approval for HD and show some more in the IMAGINE extension, it could also be considered off label for AD patients.

    Sentiment: Strong Buy

  • Reply to

    So what happens if...

    by daniel.kiely Aug 3, 2014 11:12 AM
    kadaicher1 kadaicher1 Aug 3, 2014 12:02 PM Flag

    They have plenty to fund a HD trial and I think that is where they should be going. The Parkinson's drug should be in a position to add value before too long and may cover any dilution.
    It is too soon to speculate on AD trials before the end of the IMAGINE extension trial in my opinion. In such a very early stage of the disease the extra year may help PBT2 demonstrate gains and give us a further demonstration of slowing atrophy as placebo cross to drug arm.,

    Sentiment: Strong Buy

  • kadaicher1 kadaicher1 Jul 5, 2014 11:58 PM Flag

    I also think Prana are on the right track. They need to do more than slowing the atrophy. Prana have demonstrated they can affect the process and I agree now need to escalate the dose.
    There is a normal brain atrophy rate in the elderly and I would like to see them go after that as well. That may be where AD can be eliminated.

    Sentiment: Strong Buy

  • kadaicher1 kadaicher1 Jul 3, 2014 4:28 PM Flag

    Here, but unable to attend.Everything changes so fast. When the first stage of IMAGINE ended, and all they saw to that stage was a reduction in brain atrophy, we didn't know brain atrophy was the most reliable marker of degeneration. Now we know. Many were saying the drug is right and the dose too low. Now we have crossovers in the extension trial to confirm drug related reduction in atrophy rate. Question is will they go after AD again with a higher dose, or easier targets like early HD and PD with 434, or even a combination. I hope their talks will be available on line.

    Sentiment: Strong Buy

  • Reply to

    PRAN HAS HIGHEST CASH POSITION EVER OF 41 MILLION

    by rkf302 Jun 30, 2014 2:20 PM
    kadaicher1 kadaicher1 Jul 3, 2014 1:13 AM Flag

    Prana can do a lot with 10 million. 41 million has to be very comfortable for them. When the Phase3 HD is announced there should be a spike. The new Parkinsons drug should cause some interest. The remaining AD results will be very interesting and will shed more light on future direction there. I would like to see a major effort into Parkinson's and HD before the final AD results.

    Sentiment: Strong Buy

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