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Pfizer Inc. Message Board

kccjfc 31 posts  |  Last Activity: May 27, 2016 8:15 PM Member since: Apr 17, 2008
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  • Reply to

    Finra regsho for the week

    by maybeesornot May 5, 2016 7:13 AM
    kccjfc@prodigy.net kccjfc May 27, 2016 8:15 PM Flag

    Fools are born every day.

  • kccjfc@prodigy.net by kccjfc May 25, 2016 8:49 PM Flag

    There are two contacts listed under clinicaltrials.gov for ctso's REFRESH study. One is Steve Sisk, a ctso employee with a Masters in Pharmacy, the other is Sarah Grbyz, a biomedical engineer who graduated from Worcester Polytechnic Institute in Worcester, Massachusetts in 2006. It's a top notch excellent engineering school. Ms. Grbyz now works for Boston-Biomedical, a private company based out of Cambridge, MA(think M.I.T, Harvard, Tufts, etc). Boston-Bio's focus is cancer.

    What's she doing with ctso?

    kfc

  • kccjfc@prodigy.net kccjfc May 23, 2016 10:02 PM Flag

    The management of patients with epithelial ovarian cancer with no or minimal residual disease at second-look laparotomy after aggressive surgery and platinum-based chemotherapy has not been definitively established. We report the results of a randomized study comparing three more courses of the same chemotherapy inducing the response (21 patients) with whole-abdomen radiotherapy (20 patients). Thirty-eight patients responded to first-line chemotherapy and three had stabilization of disease. In eight patients tumor debulking was performed at second-look laparotomy. No severe toxic effects were noted in both arms. Bowel obstruction occurred in one patient treated with radiotherapy. At a median follow-up of 22 months, 11 of 20 patients in the radiotherapy arm and 6 of 21 in the chemotherapy arm progressed and 9 and 3 patients died, respectively. Although the number of randomized patients is small we stopped the trial because of the survival and progression-free survival advantage of chemotherapy-treated patients.

  • kccjfc@prodigy.net kccjfc May 23, 2016 9:29 PM Flag

    Danny,

    Does PCR apply to ovarian cancer? I always thought it pcr(pathological complete response) was associated with breast cancer.?

    Thanks,

    kfc

  • Reply to

    The Boy Who Cried "Wolf" Too Often

    by bitesr May 11, 2016 4:14 PM
    kccjfc@prodigy.net kccjfc May 11, 2016 11:28 PM Flag

    CTIX's Edward Walters keeps the ducks in line(which may prompt LE to overspeak). Read his(EW's) resume, he knows what he's doing and is well respected. He's the Field General in this battle, not Leo.

    kfc

  • Reply to

    Awful 10Q.....

    by metuchen1969 May 11, 2016 4:37 PM
    kccjfc@prodigy.net kccjfc May 11, 2016 6:36 PM Flag

    On September 29, 2015, the Company entered into a Warrant Amendment and Exercise Agreement (the “Amendment”) with Lambda Investors, LLC (“Lambda”), the Company’s largest stockholder who owns approximately 62% of the Company’s outstanding common stock. Pursuant to the Amendment, the Company agreed to reduce the current exercise price of the 2007 Warrants by 50%, to $0.15 per share, in exchange for Lambda’s agreement to exercise the 2007 Warrants in their entirety immediately following the modification.

    I think we see Mieyal resign pretty soon. Trying to minimize losses based on the above "agreement"? It appears to me that that these guys are white collar crooks (Nephros/Lambda/Amron/Davidson/Mieyal). Hate to say it, ebut have been here a long time. Hope I'm wrong.
    Did anyone expect to see them offer assistance to Flint, MI based upon their public statements? If a GI grunt can supposedly filter water from an unknown pool of water anywhere in the world with their filter, why did Flint go with Brita?

    kfc

  • kccjfc@prodigy.net kccjfc May 10, 2016 10:25 PM Flag

    Bingo,

    In todays world we all have, and know friends, past classmates ,etc, who work in "finance". Some more knowledgeable than others. I'm a member of yours, which you can not trace. It's all who you know.

  • kccjfc@prodigy.net kccjfc May 10, 2016 3:24 PM Flag

    Won't claim to be knowledgeable on the subject, just cut and pasted from an article I was reading and was kind of wondering if that's the reason clsn opened their first office in in Walchwil, Switzerland last October. It's more likely because de Wit hangs his hat in Switzerland(I think).

    kfc

  • Reply to

    Finra regsho for the week

    by maybeesornot May 5, 2016 7:13 AM
    kccjfc@prodigy.net kccjfc May 9, 2016 9:00 PM Flag

    Bingo,

    Who in their right mind would buy this pos?

  • kccjfc@prodigy.net kccjfc May 9, 2016 8:42 PM Flag

    Part 2

    Comparison between a branch office and a subsidiary in Switzerland

    The branch office is easier and cheaper to set up than the subsidiary, but when it comes to liability, the subsidiary will not be affected by changes in the parent company considering its autonomy.

    From the taxation point of view, both types of companies are subject to the corporate tax on their income in Switzerland, however in some case the branch office may offer more advantages from the taxation point of view for the parent company.

    When it comes to transferring earnings from a branch office to its headquarters, there are no withholding taxes, but for subsidiaries the withholding taxes on dividends can be sent to the parent company.

    The branch office is easier and cheaper to set up than the subsidiary, but when it comes to liability, the subsidiary will not be affected by changes in the parent company considering its autonomy.

    From the taxation point of view, both types of companies are subject to the corporate tax on their income in Switzerland, however in some case the branch office may offer more advantages from the taxation point of view for the parent company.

    When it comes to transferring earnings from a branch office to its headquarters, there are no withholding taxes, but for subsidiaries the withholding taxes on dividends can be sent to the parent company.

    The branch office can engage in any type of activity such as concluding contracts and transactions but when it comes to liability, anything that happens to the parent company will extend to the branch office as well.

    Waiting for developments.

    EOM,

    kfc

  • When setting up a business in Switzerland a foreign company can decide upon opening a branch office or a subsidiary. The most common type of company used so far has been the subsidiary, but the branch office is starting to gather popularity as well.

    When considering the type of structure the company wants to establish in Switzerland it must be kept in mind the purpose of doing business in Switzerland and the independency the new office will have.

    Both types of structures are submitted to the Swiss commercial laws the same way.

    If you want to open a branch office or subsidiary, you can address to our lawyers in Switzerland.

    Branch Office in Switzerland

    The branch office in Switzerland is a satellite of the foreign parent company with no legal and separate identity. The parent company will be accounted liable for the branch office’s liabilities and activities. The Swiss branch office is allowed to conduct any operation that would represent the parent company and within the parent company’s business purposes. Swiss branch offices are treated as any other company when it comes to income taxes, but no tax is applied to gains transferred to the parent company.

    The Swiss branch office must be registered with the Swiss Commercial Register and requires at least a Swiss resident in the management board and a registered office.

    The Swiss subsidiary

    Unlike the branch office a Swiss subsidiary is a company with an independent and legal identity. The subsidiary will be created respecting the Swiss legislation and is a separate entity which makes the liabilities of its undertakings limited to its assets.

    The Swiss subsidiary can be regarded as an independent company with a majority of shareholders and management board in the parent company. A subsidiary is usually registered as a Swiss limited liability company.

    Opening a subsidiary in Switzerland does not require any business permits, only registration with the Commercial Register.

    kfc

  • Reply to

    Pretty discouraging action..

    by sam_0534 May 2, 2016 1:14 PM
    kccjfc@prodigy.net kccjfc May 9, 2016 7:34 PM Flag

    Agree,

    Good Knight Irene, sold all my shares today. Enough is enough.

  • Reply to

    What's the difference....

    by kccjfc Mar 17, 2016 11:46 AM
    kccjfc@prodigy.net kccjfc May 6, 2016 12:27 PM Flag

    Appears CELSION EUROPE LIMITED was incorporated on 04/03/2016 in Berwick Upon Tweed, UK(northeast corner of England bordering Scotland). MT listed as Director. This makes two clsn listed properties in Europe(the other being in Walchwil, Switzerland).

    kfc

  • kccjfc@prodigy.net kccjfc Apr 20, 2016 12:25 AM Flag

    Is there a first name(or last name, if Engels is the first name) associated with your referenced "Engels". Do say.

    thanks,

    kfc

  • Reply to

    fair valuation for CFP?

    by mikerobsat Apr 18, 2016 1:21 PM
    kccjfc@prodigy.net kccjfc Apr 18, 2016 8:34 PM Flag

    Mikerobsat,

    A very fair question to ask. How to analyze it is difficult to answer (in my mind)due to the company's history.

    So the newest news is the S100 Point of Use filter is approved.

    What benefit does this filter provide the consumer? per their 4/14/16 pr" it has received 510(k) clearance from the U.S. Food and Drug Administration (“FDA”) to market its S100 Point of Use filter designed to filter Environmental Protection Agency (“EPA”) quality drinking water to retain waterborne bacteria to assist in infection control."

    Question: To what extent does "Environmental Protection Agency (“EPA”) quality drinking water " NEED "to retain waterborne bacteria to assist in infection control". Is it current law that a hospitas and/or dialysis clinics provide faucets/shower heads/water system feeds with better than "(“EPA”) quality drinking water "? If yes, then I think sales could skyrocket. If these institutions(hospitals/clinics) currently comply with the law, then the law will have to change towards Nephros' specifications.

    kfc


    Read More »

  • Reply to

    china

    by gmr32003 Apr 7, 2016 3:13 PM
    kccjfc@prodigy.net kccjfc Apr 7, 2016 8:10 PM Flag

    cbidgoodpaul,

    Thanks for the reply. I'm aware of the stats you noted. Just trying to clarify with gmr32003 on the number of months that MT has stated the masses consider curative.

    MT is clear that tdox + rfa yield 80 months to date. I believe he's(MT) has also stated that for these patients with intermediate HCC, the comparative standard of care (RFA) yields a 53 months overall survival benefit. I thinks he can be quoted, numerous times, stating for this indication(intermediate HCC), 60 months is considered curative.

    kfc

  • Reply to

    china

    by gmr32003 Apr 7, 2016 3:13 PM
    kccjfc@prodigy.net kccjfc Apr 7, 2016 7:04 PM Flag

    gmr32003,

    I believe MT has often cited 60 months as the definition of "curative" for HCC.
    What is your source of the 80 month rate you mention?

    Thanks,

    kfc

  • Reply to

    Jeez even NVNT is moving

    by huncher1 Mar 31, 2016 1:39 PM
    kccjfc@prodigy.net kccjfc Apr 6, 2016 11:04 PM Flag

    Are you accusing Merlin(MASLOW) and Manny as, likened to, snakes in the grass?
    I agree!
    Nothing but bums IMHO.

    kfc

  • Reply to

    Logged In for Conference Call

    by biopharmr Mar 30, 2016 10:41 AM
    kccjfc@prodigy.net kccjfc Mar 30, 2016 11:17 PM Flag

    They said back on:
    11/11/14 that "Euro-Dignity is expected to launch in first half of 2015".
    4/15/15 "Euro-Dignity is set to begin later this quarter" (2015 Q2)
    7/6/15 ""We are aggressively pursuing opportunities to expand this program into Europe through the EURO-DIGNITY trial in which we expect to treat our first patient very soon." (Dr Borys).
    11/3/15 Hire Edwin de Wit ".....will be invaluable as he establishes broad oversight of Celsion's interests in Europe,"
    3/30/15 Said first site for Euro-Dignity will be enrolling in April(2016) and intend to have all sites up and running by end of Q3(2016).
    Can't help but wonder.....
    Missed initial projection by at least a year. Hopefully with boots on the ground in Europe now things will go more smoothly.
    Gen-1 sounds very promising for Ovarion/ peritoneal cancer(the reason I'm even in this stock was an inquiry I made to Dr Borys back 08 or 09 about peritoneal cancer(my cousin was just diagnosed with it). He advised they were not targeting it at that time but gave me some leads, which I waqs(am) grateful for. Unfortunately, she passed in 2012, but glad to see this pursuit by clsn. Another tough one.
    Optima, once they get enough wind beneath the wings(China) it should take off. HCC requires a long runway, learned that via the HEAT study.
    Dignity- Tough undertaking. I agree with MT in not pursuing it in US.
    It's good to see they reduced operating costs a little and plan to spend 10%-15% less this year.
    No method of application yet for Glio(missed the 3-4 months mentioned last November). Preclinical work will hopefully be complete by eoy. MT noted last cc that Glio could(he didn't say would) move to number one if things worked out, another tough endeavor. Will cut them slack on this.
    Bottom line is the bottom line, which, at this point, must come out of the hides of those spearheading what could presently be described as a debacle. Four peoples salary(da officers) eat ~8% of COSTS.
    Cut the #. Cut Ex salary and hire.

  • Reply to

    Earnings and guidance

    by idjut_know_nothing Mar 30, 2016 9:30 AM
    kccjfc@prodigy.net kccjfc Mar 30, 2016 10:01 PM Flag

    "dr" meiyal and arty amron, et al have been "masters" of forward looking statements. Ekfcxplains their inability to keep help(CEO's(where are yea Ernie Elgin and Norman Barta(thx for the metasorb tip so many moons ago))

PFE
34.61+0.18(+0.52%)May 27 4:02 PMEDT