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H. J. Heinz Company Message Board

kerguelen4 1 post  |  Last Activity: May 1, 2016 5:00 PM Member since: Jan 23, 2000
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    Dystrophin Quantification

    by greyzone513 May 1, 2016 4:36 PM
    kerguelen4 kerguelen4 May 1, 2016 5:00 PM Flag

    Eteplirsen-produced dystrophin would be a "spliced" protein lacking part or all of the region produced by exon 51. So one question is whether or not the eteplirsen-produced dystrophin is electrophoretically and/or Immunologically similar to "normal" dystrophin. It may be then that the Western Blot assay results could be misleading.

    Sentiment: Hold