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Aradigm Corporation Message Board

kgrichard5 33 posts  |  Last Activity: Oct 5, 2015 4:29 PM Member since: Feb 9, 2009
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  • kgrichard5 kgrichard5 Oct 5, 2015 4:29 PM Flag

    Hw thanks for the sources. Adam F. will be the last broadcast I'll listen to. Even if the ADCOM is 100% supportive of ETEP, he will try to spin the meeting to help save the ridiculously high 29 million shorts (shares). He is a reporter/analyst who usually maintains an agenda. If he is long SRPT, he will advocate. I know he has written some questionable SRPT articles and still may have some short associations to protect. Either way, I never sense his analysis contains objective or unbiased perspective. KGR

  • kgrichard5 kgrichard5 Sep 30, 2015 4:59 PM Flag

    Pearsby, I realize it is Happy Hour for you, so I'll be gentle. Number one, the dispute is insanely desperate and will not fly. BMRN has no choice but to try and throw anything and everything at the wall and hope something sticks in hopes to salvage something from their extremely poor investment. Secondly, SRPT will contend and appeal this to the end, which will take years. Bottom line, this is the line in the sand demonstrating that BMRN concedes they have an inferior product, and not by a little, but a lot. Now go back to slamming beers. KGR

  • The first statin was approved on the MOA of inhibiting the HMG-CoA reductase pathway (Mevacor), then came Zocor, Crestor, Lipitor...all approved based on the same inhibitory pathway. All were on the market at the same time, however, some were far more efficacious and had lower toxicities. Same with ACE inhibitors, 10 on the market with essentially the same MOA, but different tweeks in the labeling from different studies. My point. If there were no law suits there from follow on products that were better, how is that not the same case with ETEP and DRISA. The recent debacle from Hilary and this 5 year patent dispute before resolution favors the longs with patience and perhaps further accumulation. This patent will never fly, the drugs may utilize the same Pathway/MOA/Patch, doesn't matter..... ETEP is far more effective and efficient. End of story. KGR

  • Reply to

    remember ...

    by simp08801 Sep 28, 2015 5:20 PM
    kgrichard5 kgrichard5 Sep 29, 2015 12:36 PM Flag

    Very good post. I think if the dystrophin data is compelling and convincing all other parameters will be fully supported.

  • Reply to

    BMRN over srpt?

    by neo17a Sep 22, 2015 2:51 PM
    kgrichard5 kgrichard5 Sep 22, 2015 3:50 PM Flag

    First of all, Adam is a well informed Hack. Secondly, by 12/27 we will have enough data to ascertain the efficacy, safety and dystrophin production of ETEP. Drisa will be sitting on a failed P3, subgroup spinning, no dystrophin validation and a noncommittal confirmatory trial...testing the FDA. The FDA will be looking at this data prior to deciding on the Drisa denial/approval. The FDA will have privies to data that we will not see. However, if the ETEP data is compelling, you have it all backwards. PDUFA can always be moved up from February if the FDA s convinced of a superior product. I think Glaxo, the data, toxicity and the failed trials have it right. KGR

  • Reply to

    Just some friendly advice

    by kgrichard5 Sep 18, 2015 1:11 PM
    kgrichard5 kgrichard5 Sep 20, 2015 8:52 PM Flag

    Oneway, I am not arguing with how well the shorts have done. I am just feeling the short days are over (IMO..if that makes your insecurity level feel better). No need to get defensive. KGR

  • This technology admittedly has to take time for proper timeliness for initial intervention, duration of therapy and frequency of cytokine attenuation, but certainly a potential game changer in an unmet disease state. Hold your investment! We have catalysts galore ahead of us!

  • The day of reckoning for the shorts are closely upon us. As I have said for all these years, hold tight to your investment, especially at these prices. In fact accumulate! Our day will come shorter ( pun intended) than anticipated. Have a great weekend fellow longs. KGR

  • Reply to

    Just some friendly advice

    by kgrichard5 Sep 18, 2015 1:11 PM
    kgrichard5 kgrichard5 Sep 18, 2015 4:11 PM Flag

    Can't argue that many shorts have done well. Those who rode it from 55 to 11 (highly unlikely they hit on both ends, but possible) and covered are no longer shorts, their either out, or went long. If their still holding, they screwed themselves out of 29 bucks and will only get worse. There are also many shorts who bought between 12 and 20 and have already got their clocks cleaned and it will only get worse if they don't get out. That's the advice that was intended to be imparted. Those who are STILL short, their day of reckoning is closely upon them in a disastrous way. BTW, the real longs who bought in at .55 pre split (AVII) and accumulated at 12 post split are smiling big today and that smile I believe will become even more vibrant. Finally, I despise shorts for wishing for a technology or company to fail that can advance DMD prospects for kids....that's simply out of principle, not financial astuteness. KGR

  • kgrichard5 by kgrichard5 Sep 18, 2015 1:11 PM Flag

    Shorts, cover. You have approximately 3 hours to get out before the weekend and each upcoming catalyst rich unknown Monday a.m. Also, there is so much discussion on this board regarding the comparison of ETEP to DRISA. That is like comparing an NFL team to a Grade school team. They do not belong on the same field! Every time we use DRISA as a standard of comparison, it diminishes ETEP. It is time to focus on the attributes of ETEP without bringing an inferior product into the conversation. IF they both happen to hit the open market via FDA approval, everything will take care of it's self, in very short (no pun intended) order. Have a great weekend longs. KGR

  • kgrichard5 by kgrichard5 Sep 15, 2015 3:56 PM Flag

    letting their strangle hold go due to the imminent upcoming developments and catalysts. I can not imagine being a short at this time. It must be an extremely painful ordeal. Holding through each weekend , dreading a big Monday a.m. gap up takes kahuna's, or stupidity. It will happen and finally deliver justice and a pay off for the patients, parents and patient longs! KGR

  • A dip due to a Dip writing an article is a gift for accumulation....Meaningless.

  • kgrichard5 kgrichard5 Sep 2, 2015 2:07 PM Flag

    The later the ADCOM the better for SRPT. More conformational safety data, more parental testimonials and supportive demand for approval, more musculoskeletal and cardiopulmonary data supported by dystrophin data and 6MWT and cardiorespiratory function data. Conversely, BMRN will get weaker with time and data, especially when standing side by side to ETEP. KGR

  • kgrichard5 kgrichard5 Aug 28, 2015 11:52 AM Flag

    You could make the same case for Dow Chemical, Ford and many others stocks that were beaten down (2008/2009) to scraps. Dow Chem went fro 6 to 52, they had the same CEO and still there. The Macro market dynamics determined most of that, not the CEO. KGR

  • Reply to


    by devilsyankeefan Aug 25, 2015 4:17 PM
    kgrichard5 kgrichard5 Aug 26, 2015 10:31 AM Flag

    Sorry, just having fun. I have been on this board for 14 years and he is probably the most obnoxious poster ever.

  • Reply to

    NDA accepted!!

    by hwsimpsonshero Aug 25, 2015 5:18 PM
    kgrichard5 kgrichard5 Aug 25, 2015 5:26 PM Flag

    Awesome!! Like I said in a previous post, I could care less what the pps does between now and PDUFA. This is a major victory for the DMD families. ETEP will be the clear choice as more children experience it's pristine and effective treatment results for their horrific disease. Also, this is the spark to the other Exons being studied. This is absolutely awesome. Sorry I am so Giddy....14(AVII) years and holding. KGR

  • Reply to


    by devilsyankeefan Aug 25, 2015 4:17 PM
    kgrichard5 kgrichard5 Aug 25, 2015 4:59 PM Flag

    Nice multiple ID's My Beloved Devil. Either that, or kevin is your puppet (if you know what I mean)...since he responds in your favor within 1 minute on every post. Cowards have multiple IP's. Your Understandingly Sympathetically Sensitive to Insecurity...Beloved...Pearsby BTW.....Quits!!! Both your ID's are on Ignore...I win...haha

  • kgrichard5 by kgrichard5 Aug 25, 2015 4:51 PM Flag

    pps wise, Macro, Micro. Even if the market drags us down with an NDA acceptance. It is still great news long term. ETEP is advancing through all the necessary steps and can be a viable and effective treatment for the DMD children. Block out the pps tomorrow. Good, bad or indifferent. It will be great news for ETEP, SRPT and the DMD families. That is what we all need to focus on. JMO KGR

  • kgrichard5 by kgrichard5 Aug 25, 2015 1:47 PM Flag

    Is almost a no brainer to me. They are saying, "OK, we'll start looking at all your data that we have been telling you we need for the last two years". Simply taking the data package a reviewing it....not approving the drug. With the rolling NDA, conditional approval, ADCOM, AA and denial all options after this package acceptance. Unless I am missing something or there is some unprecedented dynamic, why would they not be ready to start unpacking the package. KGR

  • Reply to

    I am certain of this

    by simp08801 Aug 24, 2015 4:31 PM
    kgrichard5 kgrichard5 Aug 24, 2015 5:07 PM Flag

    Agreed. Their lottery ticket never seems to run out of amo, but I do believe, one day will make their last 2 years a waist of time. GLTA KGR

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