Could we see OPK over $10 this morning? Rayaldee will be huge - I reviewed the press release from OPKO on May 29th.
Rayaldee is a first-in-class oral vitamin D prohormone treatment being developed for SHPT in patients with stage 3 or 4 CKD and vitamin D insufficiency. It has a proprietary modified-release formulation designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels (at least 30 ng/mL) while avoiding upregulation of CYP24A1, a cytochrome P-450 enzyme which reduces the desired parathyroid hormone (PTH)-lowering efficacy. Gradual elevation of serum total 25-hydroxyvitamin D prevents excessive elevation of serum calcium and related vascular and renal calcification. Such side effects limit the value of current vitamin D hormone therapies. Rayaldee is expected to address the approximately 20 million patients in the U.S., and many more elsewhere, with stage 3 or 4 CKD, SHPT and vitamin D insufficiency.