AVEO Pharmaceuticals, Inc. Message Board
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assuming its this article..
Why Oculus Innovative Sciences (OCLS) Offers The Potential For Dramatic Returns In The Wound Care MarketSentiment: Strong Buy
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for you ingerdicle I am everyone you want me to be....the fact is once you are the class A hole...everyone begins to sound and look the same to you.....must be a reason for that..but you are a bit to ingerdicked to appreciate that.....and please, do not respond to me every again...because gracefully..I will never respond to you again. Have a great life you whack job...
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who ever dubbed you ingerdick had the right idea...you really are an ingerdick...have a few beers and start chanting I am ingerdick soon you will get the idea... ok..ingerdick ?
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Ingerprick..its clear why people don't like you..you really are a first class jerk. You must be miserable wreck with whatever friends and family you have. You need to go seek help if this is your outlet in life.
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no trades..
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Chemistry of Microcyn and the Fallacy of the Bleach Story (as clarified on SNOPES)
by launchbird •May 16, 2013 11:13 PM[1] Granum, P.E., Magnussen, J., The Effect of pH on Hypochlorite as Disinfectant, International Journal of Food Microbiology 4(1987) 183-187
[2] Kitaori, N, The Sterilization Properties and the ESR Spectral Intensity of Hypochlorite Acid, Electrochemistry 73(11) 2005 962-964
[3] Haas, C.N., Karra, S.B., Kinetics of Microbial Inactivation by Chlorine I; Review of Results in Demand-Free Systems, Water Research, 18(11), 1984, 1443-1449
[4] Hidalgo, E. and Dominguez, C., Growth-Altering Eeffects of Sodium Hypochlorite in Cultured Human Dermal Fibroblasts, Life Sciences, 67, 1331-1344, 2000
[5] Barnhart, b., Chuang, A., Lucca, J., Robert, S/, Liewehr, F., and Joyce, A., An In Vitro Evaluation of the Cytotoxicity of Various Endodontic Irrigants on Human Gingival Fibroblasts, Journal of Endodontics, 31(8), 613-615, 2005
[6] Barnhart, b., Chuang, A., Lucca, J., Robert, S/, Liewehr, F., and Joyce, A., An In Vitro Evaluation of the Cytotoxicity of Various Endodontic Irrigants on Human Gingival Fibroblasts, Journal of Endodontics, 31(8), 613-615, 2005
[7] Gordon, G. et al, Predicting Liquid Bleach Decomposition, American Water Works Association Journal, 89(4) 1997 142-149
[8] Adam, L.C. et al, Hypochlorous Acid Decomposition in the pH 5-8 Region, Inorganic Chemistry, 31, 1992 3534-3541
[9] The United States Pharmacopeia, 2009, USP32-NF27, Volume 3, page 3577
[10] Kikawa, S., Kitaori, N, Improvements in the Bleaching Effects of Electrolyzed Water and Sodium Hypochlorite by the Addition of Sodium Chloride, Electrochemistry 76(5) 2008, 330-333,
Kitaori, N., Takahashi, M, Improvements in the Sterilization Performance of Sodium Hypochlorite, Electrochemistry 73(2) 2005 141-144
[11] Kitaori, N., Takahashi, M, Improvements in the Sterilization Performance of Sodium Hypochlorite, Electrochemistry 73(2) 2005 141-144 -
The Microcyn™ Platform Technology generates stable, highly efficacious pH-neutral products based on the science of hypochlorous acid (HOCl). This chemical is a highly efficient, but under most conditions, an unstable antimicrobial agent that is generated by human cells as a defensive agent.
Occasionally, through a lack of understanding of chlorine chemistry, the Microcyn Technology is erroneously described as dilute bleach. Bleach is an alkaline solution (pH 11) of sodium hypochlorite (NaOCl) which is the sodium salt of hypochlorous acid (HOCl), the active ingredient in the Microcyn Technology. These two chemicals exist in a pH-driven equilibrium. At pH 7.4, there are equal amounts of both chemicals in solution while at the alkaline pH of bleach the solution is greater than 99% sodium hypochlorite. The chemical properties of these two compounds, and thus Microcyn Technology and dilute bleach, are vastly different.
Antimicrobial Efficacy: Hypochlorous acid, the active ingredient in Microcyn Technology, is 70 times more efficacious than the active ingredient in bleach, sodium hypochlorite. It has been long established that hypochlorous acid is a much stronger antimicrobial agent than sodium hypochlorite[1][2][3]. In a comparison test against Bacillus atrophaeus spores, Microcyn Technology was able to achieve a 6-log reduction at a diluted concentration of 38 mg/L Free Available Chlorine (FAC) while it required over 3000 mg FAC to achieve the same reduction with diluted bleach at pH 11
Toxicity: The high concentration of actives required for effectiveness with dilute bleach make this product toxic; Microcyn Technology has been shown to be non-toxic. There have been numerous toxicity studies undertaken on hypochlorous acid and sodium hypochlorite. While there are some minor procedural variations in the exact values, it is generally agreed that these compounds are not toxic in levels under 150-200 mg/L FAC[4],[5],[6]. Microcyn Technology is very efficacious at levels of Free Available Chlorine below the point at which toxicity begins to become an issue. Alkaline dilute bleach, however, requires significantly higher levels of actives and therefore has major toxicity issues. This has been the issue with using sodium hypochlorite products such as Dakin’s solution.
Stability: Diluted bleach products such as Dakin’s solution have limited stability requiring generation at the point of use while bottled Microcyn Technology is stable over long periods of time. Bleach is an alkaline product simply because the elevated pH gives the product stability[7]. If bleach pH is lowered below pH 11 the solution stability grows worse until a very unstable solution is obtained at pH 7[8]. The U.S .Pharmacopeia [9] has set a shelf life for acidified, diluted sodium hypochlorite topical solution (pH 7.8-8.2) at 7 days. At neutral pH, Microcyn Technology products have shelf lives of eighteen months and beyond. The unique chemistry behind Microcyn Technology generates stable hypochlorous acid in a bottle. There is no other stable bottled hypochlorous acid product available.
Chemistry: The mechanisms by which Microcyn Technology functions are the result of tightly controlled chemistry. The science of chlorine in solution revolves around chemical equilibriums between compounds of varying reactivities. It is possible through minor modifications to solution chemistry to make major changes to product stability and efficacy. It has been demonstrated that products with the same pH and FAC can have vastly different properties[10],[11]. The chemistry which provides Microcyn Technology with its unmatched stability also strongly influences the mechanisms by which the product actives function. Microcyn Technology is not just an antimicrobial; it has been shown to possess highly useful anti-inflammatory, anti-histamine and vasodilation properties. These are the result of tightly controlled chemistry and not something obtainable by simply diluting bleach.Sentiment: Strong Buy
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wow..well I guess the smallest piece of good news will really spike this one..
Sentiment: Strong Buy
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always nice to have one....mental mush....just ignore the fool from now on..he is not worth anyones time or effort....
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Ingerdicker69 told everyone that OCLS was a bad investment when it was trading for $20!!!
by ingersol69 •May 13, 2013 12:07 PMingerdick delcared GENIUS !!!
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He told larry..its just a SQL Database..any one get one one those !!!!
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they fired him because he kept telling them its just bleach.....it will never sell..anyone can mix up a batch !
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he was turned down..the CEO said " you just don't get it"
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its really the only explanation for his off the wall eratic mumbo jump....drinking bleach will do this to you..
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smart investor with a long biotech background...
Sentiment: Strong Buy
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darts from board to board floating ont the the fart of the day..is he a paid castle jestor ???? Kind of like background noise....to make you feel like there is a scene taking place...
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stock price was smashed by a two bit stock manipulator and has nothing to do with the fundamentals of the company..
Sentiment: Strong Buy