Accurate site prediction of gastrointestinal cancer by novel methylated DNA markers: Discovery & validation
Purpose: Methylated DNA markers can discriminate upper from lower GI neoplasms (Gastroenterology 2013;144(5):S84). It is unknown if organ-specific molecular prediction of GI tumor site can be achieved.
Results: From the top 100 markers, 95 were validated and used for rPart modeling. A 3- marker panel (chr12.133484978-5047, BMP3, chr11.123301058-255) was selected for the universal detection of GI neoplasms, as it classified neoplasms and control tissues with 95% accuracy. Two markers (chr7.25896389-501, QKI) then assigned lower vs upper GI neoplasms with 94% accuracy. Finally, 3 markers (PDGFD, ELOVL2, PCBP3) called pancreaticobiliary vs gastroesophageal neoplasms with 94% accuracy. All 8 markers applied in a single model (Table) accurately predicted control vs tumor by site [88% (p
he meant ~ one MT/million. While I'd like to see these guys succeed it's hardly anything to get excited about. The only thing that will save their hinnies is PLA blending. The ONLY action to focus on is in single use hospital items and fibers. imho.
Look for the /r/Solazyme - it's what's called a subreddit. there is a sign up process but it's no big deal. solazyme_investor runs the subr and deftly moderates.
Not an unreasonable thought, but I think the pathway is different from current triglyceride path. Given the scope of their R&D they're likely looking at these other pathways but they know where the focus has to be near term. They do look at mixotrophic scenarios and have previous research that points to work in other fields.
I was just catfishing. These half-baked arguments have been heard before on SA. I mean, this is the same person who considers a blood based screen superior. I was just hoping to ask a few "simple" questions and get him writing pages.
simple question (I think). If one is a high prescribing FIT doc what is the rationale for not using CG to reduce incidence of CRC diagnosis in ones practice?
Hilarious, and we're the cult members? The day someone develops a blood-based detection for pre-cancerous tumors that matches CG's numbers I'm in. The smell of desperation in the morning ... BWAHAHAHAHA HA.