Jubilant HQ is based in India they would be a good liaison for BCRX and the Indian govt.
Come on Stonehouse, let's crack the first country for approval of Rapivab!
(Received and Accepted 17 February 2015)
Emerging Problems in Infectious Diseases
The Third Wave: H7N9 Endemic Reassortant Viruses and Patient Cluster
China - Researchers say two H7N9 bird flu cases announced in February are a health care worker cluster - Shantou, Guangdong province
.A recent cluster of infections in a hospital setting in Shantou, China, is worth discussing (Table 1). Two attending physicians in a respiratory unit at a local hospital developed pneumonia like symptoms on the same day in early February. One of them was subsequently diagnosed with H7N9 and developed ARDS.
The other physician did not develop ARDS and had a milder course of illness. Repeated testing for H7N9 remains equivocal and sero conversion will be used to determine H7N9 infection status of this patient. Both patients had no known recent exposure to live poultry. A third patient who also spent time in the same respiratory unit in early February has tested positive for H7N9 and had no known recent exposure to live poultry.
More free advertising:
"More antiviral medicines, including peramivir and laninamivir as well as oseltamivir and zanamivir, are now available to treat influenza and reduce the duration and severity of infection."
Remember, 9-12 months to deliver SNS order:
Feb: 2015 (excerpt)
Over the past two years, H5N1 has been joined by newly detected H5N2, H5N3, H5N6, and H5N8 strains, all of which are currently circulating in different parts of the world. In China, H5N1, H5N2, H5N6, and H5N8 are currently co-circulating in birds together with H7N9 and H9N2.
The H9N2 virus has been an important addition to this mix, as it served as the “donor” of internal genes for the H5N1 and H7N9 viruses. Over the past four months, two human infections with H9N2 occurred in China. Both infections were mild and the patients fully recovered.
Virologists interpret the recent proliferation of emerging viruses as a sign that co-circulating influenza viruses are rapidly exchanging genetic material to form novel strains. Viruses of the H5 subtype have shown a strong ability to contribute to these so-called “reassortment” events.
H5N1 infections in Egypt
The sudden increase in the number of H5N1 human infections in Egypt that began in November 2014 and continued during January and February 2015 awakened concern. From the start of November to 23 February, Egypt reported 108 human cases and 35 deaths. The number of cases over this period is larger than yearly totals reported by any country since human H5N1 virus infections re-emerged in late 2003.
So who is this Dr. Jiandani? Notice this statement: "Clinical Decision making in patient care and Policy matters pertaining to ICU"
Dr. Prakash Jiandani has had an illustrious career in Critical Care. He has attended national and international conferences and been invited to give talks in various seminars, CMEs, National and International conferences on topics related to critical care, Malaria, Sepsis, Ventilators, haemodynamic monitoring, infection control, ARDS , antibiotic use, etc.
He was awarded the ‘Best Doctor Award’ at LTMMC Hospital in 1992. Dr. Jiandani has been a continuous ongoing clinical teacher for more than 24 years. He is also involved in teaching nursing staff, technicians and physical therapy students.
M.B.B.S. /M.D. (General Medicine) - Lokmanya Tilak Municipal Medical College (University of Mumbai)
Intensive Care: Setting guidelines, Quality Control and maintaining highest standards of patient care.
Designing and implementing Hospital infection control policies for ICU
Training of all ICU personnel for various procedures and infection control
Clinical Decision making in patient care and Policy matters pertaining to ICU and otherwise
Clinical Training of all Resident Doctors, Fellows and Staff of ICU
3. Peramivir: This is another form of antiviral treatment approved by the US Food and Drug Administration recently to fight the H1N1 pandemic. Unlike the tamiflu which is taken orally or relenza that’s inhaled, peramivir is injected intravenously to adult patients suffering from H1N1 influenza type A.
‘One advantage of this medication is that you just need one shot of injection and don’t have to follow up with a routine course of medication. However, this injection is available in the USA with a huge demand at the moment and has not reached the Indian shores yet. But we are hopeful,’ informs Dr Jiandani.
Jubilant head quarters are located in India and they have manufacturing there.
The big issue is getting through the govt. layers for approval and pricing.
Black market in India for Peramivir?
Peramivir Injection - Pune
17 Feb, 2015 Pune, MaharashtraIndia
Quantity : 10 Units
We are looking for Peramivir Injection.
Specifications :- 20ML.
Kindly send us detail and quotation for the same.
Approx. Order Value : 3,000 to 10,000 INR
Application/ Usage : It will be used for swainflu pateint at kem hospital.
Need this for : Our End Use
Want to buy : Immediately
Frequency : One Time Requirement
Preferred Location : Suppliers from Local Area will be Preferred
Peramavir Medicine Injection - New Delhi
18 Feb, 2015 New Delhi, DelhiIndia
Quantity : 10 Pieces
We are looking for 260Mg Peramavir Medicine Injection.
Kindly quote us price for the same product.
Application/ Usage : Used for saving life of Swine flu patient.
Need this for : Our End Use
Want to buy : Immediately
Frequency : One Time Requirement
Preferred Location : Suppliers from all over India can contact
Expert urges India to sequence swine flu virus
Today, 01:01 PM
With swine flu (H1N1) claiming over 800 lives in India this year, a world-renowned scientist in viral pathogenesis has called for the need to sequencing the circulating strains in the country to find out if the virus is mutated.
Voicing concern over high mortality rate, Rafi Ahmed, director, Emory Vaccine Center in US' Atlanta, has also called for screening the samples for H3N2 and influenza type B besides H1N1 virus.
Talking to reporters here Tuesday, he has also recommended that instead of the current monovalent vaccine which targets only H1N1, India should go for a trivalent vaccine to provide protection from H2N3 and type B as well.
Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza
Official Title: A Phase 3, Randomized, Open Label, Active-controlled Study to Evaluate the Safety, Pharmacokinetics and Effectiveness of IV Peramivir Compared to Oral Oseltamivir in Pediatric Subjects With Acute Uncomplicated Influenza
Estimated Enrollment: 72
Study Start Date: February 2015
Estimated Study Completion Date: June 2018
Ages Eligible for Study: 2 Years to 17 Years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
H2H is on their mind, proof by what they are doing:
Hong Kong (HKSAR) - The Centre for Health Protection (CHP) of the Department of Health (DH) today (February 24) reported the latest updates on the third imported human case of avian influenza A(H7N9) in Hong Kong this winter, and again urged the public to maintain strict personal, food and environmental hygiene both locally and during travel.
Epidemiological investigations by the CHP have so far located 17 close contacts and 99 other contacts of the patient.
(A) Close contacts
The close contacts will be put under quarantine and prescribed with antiviral presumptive treatment until the completion of the five-day treatment, or 10 days since last exposure to the patient, whichever is earlier. They include:
* An asymptomatic family member of the patient who tested negative for influenza A virus;
* Five asymptomatic healthcare workers (HCWs) involved in Queen Mary Hospital (QMH);
* Seven in-patients admitted to the same cubicle as the confirmed patient in QMH among which six were asymptomatic while the remaining one is under tracing; and
* Three patients and one who accompanied one of them attending the same private clinic in Aberdeen with the confirmed patient. They are all asymptomatic.
The Lady MacLehose Holiday Village in Sai Kung under the Leisure and Cultural Services Department has been converted to a quarantine centre for asymptomatic close contacts, including the HCWs involved in QMH.
(B) Other contacts
Other contacts have been put under medical surveillance and they include:
* Another asymptomatic family member who visited the confirmed patient in QMH;
* 77 HCWs involved in QMH;
* 15 asymptomatic clinic contacts including a private doctor, staff and patients of the private clinic; and
* Six colleagues of the patient among whom one had mild upper respiratory tract infection symptoms before exposure to the patient while the rest are asymptomatic.
Feb. 23, 2015 (excerpt)
University of Hong Kong microbiologist Dr Ho Pak-leung said the bird flu epidemic on the mainland seems to be moving south through Guangdong and therefore closer to Hong Kong. Some 54 cases have been reported in Guangdong, mainland authorities said.
Ho warned that H7N9 bird flu could mix with seasonal influenza H3N2 – the deadly strain that is causing current flu outbreaks in the city. As of Saturday, 243 people have died of flu in Hong Kong this year.
“It is possible that the two viruses could mix together and mutate,” Ho said. “The outcome is very hard to predict. The worst outcome could lead to human-to-human transmission.”
Earlier, Secretary for Food and Health Dr Ko Wing-man also raised concerns that the two viruses could mix to create a more contagious disease.
Ho, meanwhile, expected new bird flu cases would be reported after the Lunar New Year as more Hongkongers returned from the mainland after the holidays.
At this point, this is all the PR we get for this event, excerpt from the cc:
Dr. Sheridan: "We're also pleased with additional analyses of the results of our proof-of-concept study OPuS-1 has been selected for presentation at the upcoming AAAAI Conference in Houston, Texas. Dr. [indiscernible] from University Hospital Frankfurt will present a poster on February 23 that further explores the relationship between 4161 drug levels, pharmacodynamic affects and clinical benefits.
Despite a small sample size of 24 subjects, these analyses support associations between drug levels and both degree of enzyme in a patient and clinical benefit. Dr. Marcus [indiscernible] from Charité University Hospital Berlin will deliver an oral presentation on February 24th that details the improvement in quality of life and reduction in disease burdens during 4161 treatment, and explores the benefits of this drug in different anatomical sites of attacks. Although there was only four weeks of 4161 treatment in OPuS-1, disease burden was reduced and patient quality of life improved."
Report published Feb. 1
The Ebola virus could be weaponized to kill thousands of people in Britain, UK germ warfare experts have warned.
...Though few details are known about a possible plan, the report warns of “the feasibility of a non-state actor (NSA) exploiting the Ebola outbreak in West Africa for bioterrorism.”
In the light of the given turmoil this stuff gets scarier.
Stonehouse said that Ebola would be the first indication for an NDA last week at Leerink. Possible timeline of 2016 filing.
How much pressure from people dying will it take for India to make a move on Peramivir?
New Delhi: Swine flu is spreading its tentacles and has claimed 624 lives across the country in the last 45 days.
"There is no explanation and reason behind this spurt... The virus is the same H1N1 strain since 2009. There has been no mutation.
"So, it's very difficult to explain why in a particular year it has come down so drastically and, then, the very next year, it shot up again," Panda said, adding, however, that "the rise is a cause of concern".
(Reuters) - India has seen a sharp rise in the number of swine flu deaths and reported cases this year, prompting officials to investigate the cause and step up efforts to combat the virus.
Husky, I don't see them selling the rights but a low price for India is a given. The snowball of global approvals is what I want to see in the coming year(s).
I don't know what BCRX will do with this info. but I don't expect it on a cc slide. I imagine they'll announce the event in a separate PR. This presentation is added "color" to what we already know.
I don't care what the shorts do, I care what BCRX does and the record shows they have performed excellent and have a strong list of catalysts for 2015.