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Ligand Pharmaceuticals Incorporated Message Board

markak1515 22 posts  |  Last Activity: Nov 19, 2014 10:37 AM Member since: Apr 15, 2005
  • markak1515 by markak1515 Nov 19, 2014 10:37 AM Flag

    Go to clinicaltrials.gov and type in "macrogenics." Look how many failed drugs are listed there: MGAWN1, RAV12, I would also put teplizumab in that category. These guys are well respected for some reason but they've never accomplished anything, all they do is sign deals and collect milestones. Drug fails, move on, sign more deals, collect more milestones. It's like a biotech pyramid scheme.

    The collaborations that MGNX has set up are the only thing to like here, but even their collaborators are flying blind. The recent Takeda agreement did not specify targets. Takeda is just interested in exploring the platform further.

    Bispecifics are not exactly new. Micromet has been working on this since at least the early 2000s according to their publication record. Has anyone out there seen any data showing that bispecifics can do anything but deplete CD19+ cells? Nope.

    Furthermore, while MGNX management brags that they have cash to 2017, look at the completion date for most of their phase 1 studies. 2017. So in 2 years, this company will be out of cash and ready for phase 2...if any of their molecules show activity at all.

    Don't be fooled by the string of deals Macrogenics has put together. People are interested in the DART platform, but their interest will soon fade when they start seeing phase 1 safety data.

    Sentiment: Strong Sell

  • markak1515 by markak1515 Nov 17, 2014 5:36 PM Flag

    Looks like they all had their trading plans set to trigger if the stock hit $23. Kind of sad.

  • Reply to

    What's Wrong With This Board...???

    by golongin2008 Nov 12, 2014 6:00 PM
    markak1515 markak1515 Nov 17, 2014 9:57 AM Flag

    I would be happy to cover at $21 or 22.

  • Reply to

    What's Wrong With This Board...???

    by golongin2008 Nov 12, 2014 6:00 PM
    markak1515 markak1515 Nov 16, 2014 10:29 PM Flag

    I'd say it's easy money. Market overall is at all time highs, MGNX business development guy is willing to let A LOT of shares go at $23-25/share. Any molecules that have a chance of working are phase 1 or pre-clinical. What is going to happen to move the stock up? Nothing, at least not in the next few weeks.

  • Reply to

    CC

    by steve.higgins16 Nov 15, 2014 6:32 AM
    markak1515 markak1515 Nov 15, 2014 2:17 PM Flag

    A few questions/comments:

    1) QIDP status comes with automatic fast track. So why would you bother applying for fast track and then applying for QIDP separately? Why not just apply for QIDP and then get both from 1 application? There must be a reason, but I don't understand it at this point. Anyone else know?

    2) The Neutrolin monitoring program - this is a great idea and I'm glad the data are looking extremely favorable. There's just one problem. Neutrolin is not selling in the EU and it's NOT because people don't believe it works. It's because TauroLock with Heparin is well established, probably around the same price or maybe cheaper, and people have no compelling reason to switch.

    3) I plotted cost of sales and net revenue for the last 3 quarters. The lines are at least headed in the right direction. We started with $12k in rev and COS over $81k. Now rev has gone up 4X and COS has dropped to $37k. So while all these numbers are quite small, at least the trend is favorable.

    4) 2 analysts on the call from Dawson James and Maxim. As far as I know neither one currently covers the stock. It would be nice to get more coverage as the CRMD story matures.

    There have to be companies at least considering buying CRMD at this point. For maybe $100-150M, you get a product which has beyond a shadow of a doubt, been proven to be safe and effective, you have the US market which is completely untapped (no competition) with an easy 1 and done study for approval, then you throw in the wild-card of the EU litigation and a possible $50M in revenue annually if their lawsuit is successful (and additional potential sales in other countries which accept the CE Mark), and it seems like a tremendous deal and a no brainer acquisition.

    When there is little doubt that the phase 3 study will be successful, that's when you acquire instead of partner. Why partner at this stage? No risk of failure and you'll just end up paying more post-phase 3.

  • Reply to

    GAIN Act not filed yet???????????

    by luckytrufflepig Nov 14, 2014 9:14 AM
    markak1515 markak1515 Nov 14, 2014 9:49 AM Flag

    props to Doug for asking the question to get more clarity on that issue.

  • Reply to

    5:51am PST

    by myklecg Nov 14, 2014 8:52 AM
    markak1515 markak1515 Nov 14, 2014 9:41 AM Flag

    Let's just hope they deliver their fast track/QIDP Christmas present. I"m not really sure why they bothered to file a separate application for fast track because QIDP comes with automatic fast track status. I must be missing something...

  • Reply to

    Earnings Out today

    by myklecg Nov 13, 2014 3:06 PM
    markak1515 markak1515 Nov 13, 2014 7:23 PM Flag

    If you want an EPS story, buy Apple or something. Yes, rev sucks but there is a clear reason. It starts with T and ends with Pharm. Lawsuit has been filed.

  • Reply to

    What's Wrong With This Board...???

    by golongin2008 Nov 12, 2014 6:00 PM
    markak1515 markak1515 Nov 13, 2014 6:01 PM Flag

    Anyone mentioning a buyout is nuts. First of all their business development guy just sold over $500k in stock. He would be the one orchestrating the buyout if there was one. Secondly, their only late stage drug is margetuximab which is an undifferentiated asset which has yet to prove itself in the clinic and there are already approved drugs out there that are likely equivalent or possibly superior to margetuximab. No one is going to buy the copmany for margetuximab. Beyond that they have only very early stage stuff. Big pharma does not pay premiums for completely unproven molecules. No one is going to buy an oncology company pre-phase 2. I'm short from $25. These guys are 5 years from even having a mature phase 2 data set from a molecule that is commercially viable. If the market corrects this could easily be a $10 stock.

  • Reply to

    CC Nov 15th?

    by luckytrufflepig Nov 6, 2014 10:50 AM
    markak1515 markak1515 Nov 6, 2014 5:42 PM Flag

    I'm not so sure now. The guidance says fast track can be applied for at time of IND filing or after. No idea if QIDP follows those same rules. One would think they would want to file for QIDP as soon as possible, but who knows.

    Call just scheduled for 9 am EST on Friday 11/14 with numbers after close 11/13.

  • Reply to

    CC Nov 15th?

    by luckytrufflepig Nov 6, 2014 10:50 AM
    markak1515 markak1515 Nov 6, 2014 12:21 PM Flag

    that was sarcasm in case it wasn't obvious. I'm actually hoping they are waiting to hear from FDA regarding QIDP, and hopefully we get a joint QIDP/Q3 earnings call. QIDP/fast track would be big news worthy of a conference call, even if it's just a dog and pony show

  • Reply to

    CC Nov 15th?

    by luckytrufflepig Nov 6, 2014 10:50 AM
    markak1515 markak1515 Nov 6, 2014 11:33 AM Flag

    no I think they've having a special Saturday call in order to enhance analyst participation. Their usual "announce the call 48 hrs in advance and schedule it at 6 am for half the country" just isn't cutting it.

  • Reply to

    QDIP Regulations.....

    by czar2558 Oct 27, 2014 6:39 PM
    markak1515 markak1515 Oct 29, 2014 12:10 AM Flag

    CRMD definitely filed paperwork for QIDP or maybe breakthrough when they filed the IND, that's just how it's done. We will hear by 11/21, I suspect much sooner.

  • Reply to

    Warrants......

    by czar2558 Oct 28, 2014 5:56 PM
    markak1515 markak1515 Oct 29, 2014 12:06 AM Flag

    March 2015, not sure of exact date. If the stock is above the strike, then warrant owners will buy stock at $3.43, CRMD gets the cash and issues new shares to the warrant holder. So it's dilutive but "naturally" dilutive. I would love to see the warrants exercised because it means 1) the stock is north of $3.43 and 2) CRMD's cash situation would improve dramatically (4.5M warrants x $3.43 = $15M)

  • Reply to

    Cytokine

    by darkroast33 Aug 7, 2014 12:50 PM
    markak1515 markak1515 Oct 20, 2014 9:33 AM Flag

    It looks like the most advanced ebola vaccine is an adenovirus expressing an ebola surface glycoprotein...don't believe Thermovax would work with a live virus vaccine.

  • Reply to

    Cytokine

    by darkroast33 Aug 7, 2014 12:50 PM
    markak1515 markak1515 Oct 17, 2014 10:44 AM Flag

    I wasn't saying they should get into Ebola, but if they were going to do it, leveraging the Thermovax platform would be the way to go.

    I'm surprised the stock recovered so quickly from the dip to the $1.30s. I'm still waiting for the next round of financing to add to my position....

  • Reply to

    Cytokine

    by darkroast33 Aug 7, 2014 12:50 PM
    markak1515 markak1515 Oct 15, 2014 9:34 PM Flag

    How exactly is SNGX going to mitigate cytokine storm? Straube is going to invent a new molecule? In CAR T therapy, the lethal effects of cytokine storm have been ameliorated by treating with tocilizumab, implying that IL-6 is the key "toxic" cytokine in the storm. It's an expensive drug though, dosed by IV infusion, which must be refrigerated, not something we can easily roll out to western Africa.

    I can understand making an argument for SNGX to get into Ebola but the more rational and realistic approach would be to develop a heat stable vaccine which could be easily distributed in Africa without the cold chain. This would not be a trivial undertaking, but SNGX could easily create a lot of hype and a 2X in the share price just by announcing they are working on it.

  • Reply to

    SGX230 a perfect fit!

    by darkroast33 Sep 24, 2014 4:25 PM
    markak1515 markak1515 Oct 15, 2014 10:25 AM Flag

    These analyst price targets are completely ridiculous. Griffin is basically Randall Kirk's marketing arm. Vista I believe is paid coverage. This is not going anywhere near $7 anytime soon...that's just reality.

  • Reply to

    Cytokine

    by darkroast33 Aug 7, 2014 12:50 PM
    markak1515 markak1515 Oct 15, 2014 10:24 AM Flag

    And your point is???

  • Reply to

    Slow Death

    by garyjc2 Oct 6, 2014 1:05 PM
    markak1515 markak1515 Oct 9, 2014 6:46 PM Flag

    In 1 day, yes. In weeks or months, no!

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