We present data showing that IDH2 R140Q mutant expression leads to DNA and histone hypermethylation that can be reversed on treatment with AGI-6780, a potent IDH2 R140Q inhibitor. Previous studies have shown that IDH1 and IDH2 mutations functionally block cellular differentiation and that this block is dependent on elevated levels of 2HG.9,10 The results reported here provide mechanistic insight into the roles IDH mutations and elevated 2HG play in blocking cellular differentiation through epigenetic reprograming.
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They have an understanding of the opiate system in the CNS. They also did the impossible - made a form of olanzapine without weight gain.
Pancreatic cancer is an extremely difficult disease to treat, in part because of a hyaluronan-rich matrix which shields these tumors against chemotherapy," said Daniel D. Von Hoff, M.D., F.A.C.P., lead principal investigator of the study and Chief Scientific Officer for Scottsdale Healthcare's Virginia G. Piper Cancer Center Clinical Trials and Physician-In-Chief for the Translational Genomics Research Institute (TGen). "Ongoing translational studies indicate that PEGPH20 may deplete this matrix component from pancreatic tumors and alter the tumor environment in a way that renders these cancers more vulnerable to therapy."