red_bull, you are acting like you are one of those Jakafi-lobby guy!! Just look at the explanation in appropriate scientific and authentic documents to see why Dr. Tefferi or others at Geron did not consider this to be a serious problem!! Are you more knowledgeable than Tefferi who tried this drug on many patients and studied the side effects deeply? Do not loose sight of the fact that this drug is the first known life-saving drug for DYING cancer patients and not those Lipitor or Tylenol users who will live much much longer!! Use your common sense before becoming a devils' advocate, please!!
Thanks, spectro. You and paldridge are the only one with good comments so far; of course I see five thumbs up and one down! Well, in a democracy, the power of people doesn't work if people remain subdued or silent.
MLV guys are bunch of WS guys who live only in the WS world and have very little outside knowledge or even common sense. They do not understand the power of patients and lawyers. When these #$%$ find that there are other factors that will force the FDA to speedup the process, they will tell their client to buy Geron. They flip-flop often like that!!
Perhaps a certain restricted word if not a link! I did not type the entire link and just a part of it and yet was not allowed until I removed that and deliberately misspelled or played such other trick.
Yes, Black, I read that post from Irish day before yesterday. I believe that the FDA can not stop patients already taking Imetelstat treatment and corresponding studies being performed. My understanding is that the FDA asked Geron (and also perhaps Mayo) to stop admitting any more new patients. This clarification is not sought by any questioner from Scarlett during the CC. However, in my view, the FDA can not dare to stop any on-going treatment because if it does so and a patient dies, it will be subject to a lawsuit. Thus, the FDA action, in my view, to stop any actively recruiting trial is simply meant to delay the process. Whether their intent is good (in case it wants to clarify sticking points prior to a fast-track approval) or bad (just knit-picking), I am just assuming at this point that it's the latter based on the Jakafi lobby's propaganda all over the media, including the MPN Forum and scientific gatherings and journals (like the one by Dr. Silverman from NY City).
beavertail, look at the Scarlett's statement in his CC on 12th (Seeking Alpha already has issued the draft - Yahoo Finance). He explains all this in the detail. I suggest readers of this post to study the statement by Scarlett.
Well, the word ALL is used in the announcement by Geron. My point is not this or that trial, but the ET and PV both are halted and the proposed Geron's MF trial is also delayed for the same reason (since it's not yet started, delaying means halting!) if you are are knit-picking for grammatical error.
That has been going on for quite some time and if you follow other biotechs their MMs also do the same!! MMs manipulate trading in a way that it remains active and the buy-sell activity brings them more business. Their best clients get preferential treatment and the MMs help them while helping themselves. All that is kept subtle as far as possible. The SEC allows this as long as it's within the guideline; but, these WS crooks know that SEC can't monitor every little thing that goes on in the market because the SEC doesn't have enough resources or capability to monitor and catch culprits when it has to do so for tens of thousands of securities all across our several exchanges!! Unless you fill out the complaint form giving specific details, I bet the SEC won't even look at what is going on for a tiny exchange entity like Geron!!
What conspiracy? Perhaps a nut or two at the FDA brainwashed by the Jakafi lobby propaganda may have prevailed at the FDA. The idea may be just to put roadblocks in the licensing of Imetelstat so that the Jakafi suppliers can shovel in additional billions from all over the globe before Imetelstat is allowed to hit the market, primarily from the cancer centers all across the U.S.A.!! And, what does it cost to do that to the lobby - hardly a few million dollars? Do you see the huge net advantage they have?
Hey, we live in a capitalist country where money seems to rule, isn't it?!! We, the people must lodge a forceful opposition to such practices to beat them; otherwise, this kind of things will go on. After all, we are a democracy and we, the people, must take power in our hands and not let it go to the WS dogs. Simply complaining on this ineffective board won't do it!!!
Make sure that no web site is included in the material you copy and post. That happened to me several times. The Yahoo monitoring is computerized and a robot decides if the post is allowed or not!!
Those who are suffering from the deadly MF, ALM and MDS or even ET and PV and their immediate family members MUST lodge a forceful complaint through their Representatives and Senators against the FDA's incomprehensible halt of all Imetelstat trials just under the excuse of a concern for the persistent ow-grade liver function damage. I believe such damage is known to have been caused by even excessive use of hard liquors and drugs like Lipitor approved by the same FDA for use by much healthier people than Imetelstat will be used for. For example, the MF patients that will be in the trial for Imetelstat will be primarily those who will die anyhow within a few months to hardly a couple of years without the Imetelstat treatment! Also, patients for the other cancers will be in the same boat, unlike those who use Lipitor!! Furthermore, these are just Ph 2 trials, the FDA has sufficient time to observe any exceptional damage by the time Ph 3 of the trials complete and the FDA grants the license. Then, why so much fuss by the FDA now just for the low-grade damage that the doctors even at the famous Mayo are not concerned about?
Two law firms have already announced their intent to investigate and file class-action suits. If these go through, the FDA may have been afraid that its misdeed and perhaps their suspect hanky-panky relationship with the Jakafi lobby will also be exposed!! The FDA bosses must now be arguing among themselves about the all-trial halt action just for low-level liver damage that possibly can be repaired and is no different than using Lipitor already approved by them!! Oh, what a circus it is going to be!! Let us just watch the fun things going on at the FDA.
May be the phone call was placed by a nut who is on the hot seat at the FDA now. The FDA bosses are now scared by the inquiry from the four Congressmen and pressure from the cancer patients and families suffering from the deadly cancers!! I suspect that the letter now would be much more compassionate than the verbal order!! Kind of about face by the FDA!!
Black, that's why I have been screaming all along that Jakafi agents must have been at the FDA. What else could be any stronger reason for the incomprehensible halt for ALL trials, especially if the persistent lower-grade liver damage is the only reason and for patients who are going to die in a short time anyhow if the treatment is not available to them!! Buddy, even the hard liquor, and extended use of Lipitor and Tylenol (both approved by the same bloody FDA) are known widely to cause perhaps more liver damage than that!!
The FDA action, to me, is strongly suspect of being influenced by the Jakafi guys who are also controlling what comes out of the NY City financial district, the most immoral place in the country where extreme greed and, hence, cheating and lying prevail. Piper Jaffray and others belong to that place.
nom, if you look at each pre-market trade to-day, it started @ $1.77 or thereabout because someone retail had a buy order but it started falling all the way to $1.70 until 8:00AM, meaning those were initiated by retail sell orders.
After 8:00AM when the SP was nearly $1.75, ,you will find those were also small retail trades all the way till market opened. However, during this time, the sell orders exceeded the buy orders and, hence, the SP kept dropping from $1.75 to $1.61 just before the market opened. But, just at the opening, apparently an institution placed an order for a total of approx. 1M shares and that caused a spike from $1.62 to $1.95. This huge buy order was followed almost immediately by a sell order of almost the same size that brought down the SP to $1.75. Do not forget that for each share sold there must be a buyer and vice versa. The SP is lowered if a sell order preceds a buy order and vice versa if the SP goes up.