Amarin Corporation plc Message Board
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Japanese doctors analyzed JELIS data and reported their findings in Journal of Atherosclrosis and Thrombosis in 2011 and 2012. Here are conclusions from 2011 article.
Pure 96% EPA(EPADEL) reduced Inflammation as measured by AA/EPA ratio by half. Their conclusion-Inflammation was key to reduction in CV events.
Conclusion from 2012 Study:
DHA correlates with LDL. However EPA has no correlation.
This is consistent with LOVAZA raising LDL by 49%.
Majority of Cardiologists believe than LDL and C_RP are important indictors to focus on in therapy. Lower LDL and C-RP are impprtant.
EPADEL and VASCEPA lower C-RP,besides Trigl.
There was a cardiologist on Dr.OZ TV show--Dr,Sinatra. He said he focuses on Trigl./HDL ratio-as that has shown to cause CV events.He does not prescribe Statins.
Recently--Dr.Topol questioned the wisdom of high dose of Statins because of raised risk of diabeties from Statins in NY Times Op.Ed. -
What is your sugar levels--fasting ?
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Do you take Lipitor or some other Statin?
Statins tend to affect Sugar-Type 2 diabeties.
I am amazed at HDL fluctuation. -
I tried Plusepa before Vascepa was available. That helped HDL from 44 to 52.LDL down from 93 to 76.But that is over one year. I still take Lipitor 20mg./day.
My biggest problem with Lipitor is borderline Type 2 diabeties --135 vs,.it should be no more than 110 with fasting.My blood report since last 6 years has shown diabeties concern.I have cut down from 40mg./day of Lipitor--but substituted Vascepa --I will wait 12 months to see the impact on sugar.
I am very regular on exercise--eat salmon one/twice a week. No red meat at all.Rely on Veg./fruits/nuts/beans etc.Eat Fish/meat 4 times/week. -
Before Vascepa,I took Fish oil for several years,then switched to Plusepa--. Plusepa worked wonders lowering my TG under 100 and LDL went down and HDL went up.
I showed that data from 2009 to 2013 to my doctor.He knew my TG problem and Lipitor did not help much.He was convinced.
Now RX for Vascepa is approved by my insurance-but Plusepa is not.I was paying roughly 2$ per 1 gram pill for Plusepa. Vascepa is much cheaper option. -
Sales Rep. are giving doctors 2 Vascepa Cards and 4 free samples for starters(to see if taste/size OK) for patients.With Card-- price drops by 100$ for first prescription without INSURANCE.
With Insurance-cost is ZERO for first prescription. -
I got my first prescription--paid ZERO with Coupon and United Health insurance(Caremark).
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JELIS data is being analyzed by researchers in Japan as it is full of very interesting information for 18000 persons in Japan. 2 articles were published in Journal of Atheroscelerosis/Thrombosis in 2011 and 2012 .
Conclusion: Inflammation was reduced by 50%--as measured by EPA/AA ratio
DHA is positively correlated with Bad Cholestrol-LDL
EPA is not correlated with LDL
Dr.Yokoyama in an interview with Heartwire in 2007 speculated that Inflammation was perhaps KEY to CVD reduction. The article in 2011 confirmed it.
Dr.Barry Sears of Zone-Diet--best seller book--told me that Americans have very high AA/EPA ratio--compared to Japanese--that is why CVD is very high in America compared to Japan.
Dr.Sears told me that Reduce-IT study should have included 6 gram/day dosage of VASCEPA also-to get the best results.
If you recall, Astra Zeneca's CRESTOR used C-RP to select the patient population for Jupiter study.The average C-RP was 4.3-- any value over 3.0 is considered HIGH-Risk of Heart attack. Jupiter Study showed great results after 2 years of complete data in 2009.FDA approval document shows that it is recommended for people with C-RP over 2.0.
Vascepa with Lipitor should show good results.
JELIS used Epadel with Zocor and Pravachol. - Reply to
Pharmaepa CEO tells Feuerstein--his sales up sharply with Vascepa publicity.
by mtdsus •Apr 5, 2013 11:54 AMAlso they sell thru providers--implies doctors.
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Pharmaepa CEO tells Feuerstein--his sales up sharply with Vascepa publicity.
by mtdsus •Apr 5, 2013 11:54 AMAKANZ-- please read and comment.
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AF article quotes CEO of Pharmanet saying-His sales up due to Vascepa publicity.
I checked the prices-- 25$ plus shipping(discounts available) for 60 Pills--but 2 Pills contain 560mg. of EPA.That is 2 $ per 1 gram EPA.
In 2013-- with Coupon--you can get Vascepa for less than 1.1$ per 1 gram pill for first prescription and 1.3$ per 1 gram pill. If you have insurance--your cost is ZERO for first prescription.
Phramaepa is sold mainly thru PRIVDERS according to their website and it is not FDA approved.
My guess is that providers make money for selling this product.
AKANZ --please comment? -
2 studies published in 2011 and 2012 using JELIS data--proves:
1) EPA lowers inflammation in arteries.
2) DHA raises LDL--EPA does not. -
This researcher has been doing research on this subject for over 10 years.Heartwire asked him to comment on JELIS study.
ORIGIN study was a big study for 6 years for Fish Oil--paid by Fish Oil manufacturers/marketers. It failed and results were announced in July,2012.This study was done in USA.
Check out his Bio on Harvard--these studies show up. -
Heartwire had 4 articles on JELIS and VASCEPA incl.Anchor trials. Recently,an article headlined:
DHA is positivly correlated to LDL-confirming Lovaza data showing LDL up by 49%.
Actually Dr.Mozaffarian was interviewed about JELIS study in 2007.Here is what he said,
" This study used 1800mg./day of EPA in addition to 250mg./day as part of Japanese diet."
Origin Study in USA--last year created more damage for Fish Oil among Cardiologists.This study used over the counter-Fish Oil and Dr.Bhatt Audio commented on this study.
This professor did another study for Surgical patients-giving them Fish Oil before/after surgery--Study was discontinued after 2 years of poor results-last year.
One of top Cardiologist told me that he would like to see the results of Reduce-It. He considered JELIS results weak- he did not elaborate what weak means.This top Cardiologist knows Dr.Bhatt well and respects his competence in conducting "Strong-Proper studies".
By the way--Amarin left sample of Vascepa and couple of Free Card with my internal medicine doctor 2 days ago.He is going to try Vascepa with 2-3 patients,then after 4 months--if results are good--change prescription for other patients.He trusts his own research --with his patients blood reports to assure him that Vascepa is better than Lovaza. -
My doctor received literature and a visit yesterday after he contacted Amarin .It took 4 weeks.
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If you have registered on VascepasavingsDOTcom and printed coupon--take it to the pharmacy(Walmart ,Wegman ,CVS etc.) and show them your Drug insurance card.
I did that--ZERO payment for 120 Pills of 1 gram for first time.
Make sure that the Pharm.asst. properly processes the Coupon.Wegman's did NOT--so I asked them to recheck--and 10 min. later-said--YES--zero charge. -
Jelis data was analyzed by Itakura -not involved in JELIS original study in 1999-2005.
Their 2 article in 2011 and 2012:
1) DHA correlated with LDL-- higher DHA leads to higher LDL
2) EPA not correlated with LDL--higher EPA does not raise LDL. (remember Jelis used 1.8 gram/day of additional EPA for Japanese who eat .250gram/day of EPA in diet.
3) REDUCTION in CVD due to INFLAMMATION--used EPA/AA ratio for Placebo using 10mg./day of Zocor or pravastatin versus Statin with 96% EPA-Epadel -
Earlier I said- 25$ --but spoke to pharm.asst.She said-coupon was not used--then she applied the coupon and I ended paying Zero for first prescription. I was paying 245$ for PLUSEPA /month as it is Not covered by Insurance.
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Using coupon from vascepasavingsDOTcom-- I only paid 25$.Rest picked up Amarin and my insurance(Caremark-Wegman's)
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Please go to VascepasavingsDOTcom and this way you can save 100$ for first prescription and 75$ for next prescription in 2013. This way--you get it very cheap. I have drug insurance--Wegman pharmacy(Caremark affliated) told me that after applying these coupon-cost was 93.68$ for 120 Pills for one month. I have to pay 25$ only out of remaining 93.68$. 25$ charge for first month for 120 Pills is great.