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Synta Pharmaceuticals Corp. Message Board

munificent_gnome 3 posts  |  Last Activity: Aug 11, 2015 10:00 AM Member since: Mar 17, 2000
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  • Reply to

    Mgm and bio

    by munificent_gnome Aug 10, 2015 2:40 PM
    munificent_gnome munificent_gnome Aug 11, 2015 10:00 AM Flag

    Thanks Mgm and bio. I bought more of both today for the long term. GLTU.

  • munificent_gnome by munificent_gnome Aug 10, 2015 2:40 PM Flag

    Do you own more IDRA or TROV? Which do you think has a greater upside? TIA.

  • Reply to


    by emptor_of_ooze Jul 17, 2015 7:15 PM
    munificent_gnome munificent_gnome Jul 17, 2015 8:32 PM Flag

    Treatment of two patients with generalized pustular psoriasis with the interleukin-1β inhibitor gevokizumab.
    Mansouri B1, Richards L2, Menter A1.

    Generalized pustular psoriasis (GPP) is a severe, potentially life-threatening inflammatory dermatosis, which is traditionally difficult to manage. Recent evidence suggests that interleukin (IL)-1 plays a central role in the disease pathogenesis, and thus makes the use of IL-1 inhibitors potentially effective. Two patients with severe, recalcitrant GPP were enrolled in an open-label, expanded access study to receive a new IL-1β inhibitor, gevokizumab. The two patients had a respective 79% and 65% reduction in GPP area and severity index scores at weeks 4 and 12, with some improvements in quality-of-life instruments. There were no significant adverse events related to the study medication, although one patient developed an abscess in a haematoma secondary to an injury. Both patients showed substantial initial clinical response to gevokizumab, with no significant laboratory abnormalities noted. These cases illustrate the growing need for targeted, efficacious therapies for this severe, debilitating disease. Prospective randomized control studies are required to further assess the safety and efficacy of IL-1β inhibitors for the treatment of GPP.
    © 2014 British Association of Dermatologists.

    Hoping Xoma can rise up from the ashes like a phoenix!

    Sentiment: Strong Buy

2.03+0.01(+0.50%)Sep 4 3:59 PMEDT