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SIGA Technologies Inc. Message Board

musherga 156 posts  |  Last Activity: Apr 7, 2015 10:15 AM Member since: Apr 19, 2007
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  • Reply to

    improving insulin sensitivity

    by musherga Apr 6, 2015 12:39 PM
    musherga musherga Apr 7, 2015 10:15 AM Flag

    Not Afrezza specifically. Injectables do this too. But the injectables carry much higher risk of "stacking" the insulin levels which can cause hypoglycemia. The key is tighter control of the peaks with safety.

  • musherga musherga Apr 7, 2015 10:07 AM Flag

    I have observed that advertising ramps up near the end of a products life. Tamiflu is a good example

  • What I'm seeing in research papers is that controlling post prandial BS levels decreases the amount of basal insulin needed for control. Taken together this can produce a significant reduction in A1c. A1c is a proxy for tissue damage caused by high blood sugar. Afrezza will eventually get labeled for prediabetics and gestational diabetes IMO

  • Reply to

    Has the DSC decided to review this again?

    by hosaquavas Mar 31, 2015 2:38 PM
    musherga musherga Apr 1, 2015 3:04 PM Flag

    No decision in the appeal. Siga has submitted opening arguments. AFAIK next is PIP rebuttal. Bankruptcy proceedings come up again in June at NY court.

  • Reply to

    Roth Analyst...

    by bionerd51 Apr 1, 2015 5:19 AM
    musherga musherga Apr 1, 2015 9:48 AM Flag

    Chapter 1 in How to Win Friends and Influence People

    "If you want to gather honey, don't kick over the beehive"

  • Reply to

    This is what will sell it to the Drs

    by brewman228 Mar 26, 2015 2:19 PM
    musherga musherga Mar 26, 2015 4:11 PM Flag

    Awesome control. I believe this product will eventually be used to treat metabolic syndrome. 34% of adults in the US had this condition in 2009.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 1:29 PM Flag

    Thinking of losing another 20 pounds and exercising more to get off metformin. It would be tempting to take a hit of A and eat a half gallon of ice cream, though.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 9:53 AM Flag

    Normal range for A1c levels weren't established until after a major shift from fat to simple carbohydrate began to occur in our diet. I think we will find that a good fasting BS level is closer to 50 than 100. The bs spikes also affect lipid transport such that more fatty acids accumulate in blood, raising triglycerides and LDL cholesterol.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 9:45 AM Flag

    I think there is an acceptance of high blood sugar levels as long as the mean stays in a range above normal for A1c. But A1c is just a proxy for glycation. Other tissues (besides red blood cells) are affected by high sugar levels. A1c can be maintained by lowering the baseline or reducing large excursions from the base. I think the spikes are more important because they cause the T2 disease itself, presumably by causing insulin resistance over time in persons genetically predisosed.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 9:30 AM Flag

    Not surprising. Another excerpt from the article:
    As Schafer hypothesized, insulin has two classes of action: (i) excitatory (autacoid), for example stimulating glucose uptake and lipid synthesis; and (ii) inhibitory (chalone), for example inhibiting lipolysis, proteolysis, glycogenolysis, gluconeogenesis and ketogenesis. These dual actions are illustrated in Fig. 1, where insulin’s well recognized action in stimulating lipogenesis from glucose (in rat adipocytes) is illustrated.6 What perhaps is less well known is insulin’s simultaneous inhibitory action on lipolysis. It is quite clear from Fig. 1 that both these actions occur simultaneously over the same concentration range. They are both mediated through the same cell membrane receptor. These actions of insulin in vitro were discovered in the late 1950s when it was also shown that insulin stimulated glucose uptake by rat muscle. It was extrapolation of this last observation in rat muscle to explain the pathophysiology of diabetes that was erroneous. The consequence of this error was the (fallacious) concept of insulin being ‘required’ for glucose entry into cells rather than just accelerating glucose uptake. The hyperglycaemia of diabetes was interpreted as a ‘damming back’ of glucose in the blood stream as a consequence of a lack of insulin. This became established teaching and, although the concept was shown to be erroneous in the mid‐1970s, the teaching has not changed. Consequently, therapy has been based on a flawed concept.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 5:25 AM Flag

    It may well be the case that the spikes and subsequent damage are what cause derangement in glucose managent. Certainly reduction in the magnitude of sugar levels around mealtime will slow progression of disease. I believe under the right circumstances type 2 diabetes can be reversed. This except from the british journal of anesthesia explains why.

    Insulin normally has a tonic inhibitory control (what Schafer termed ‘chalonic’ action) on the supply of energy substrates arising mainly from metabolism in the liver, muscle and adipose tissue. Normally insulin ensures sufficient release of appropriate substrate to allow humans to cope with the eventualities of life in a highly controlled manner. Once insulin deficiency develops this control is lost, and energy substrates are over‐produced and flood the system. The metabolic consequences result from the excess of substrates not (as is often misconceived) by a lack of energy substrate getting to the tissues.

    I'm a pre-diabetic, on metformin.

  • I did some research. Here is my conclusion: it is important to control bs spikes. The so-called basal levels primarily inhibit gluconeogenesis, the process whereby glucose is synthesized in the liver. This mechanism provides glucose for glucose-dependent tissues while sugars are not being assimilated from food. Without insulin, blood sugar rises while fasting. But basal levels are not adequate in the face of sugar liberated during digestion of food, especially simple carbohydrates. The digestive process triggers a rapid but transient release of insulin from the pancreas that triggers uptake of glucose by tissues that can sink the excess. In some individuals up to 70 times the basal levels are secreted normally to control exogenous sugar. Excessive sugar causes glycation of protein, whereby crucial proteins are rendered inactive due to permanent binding with sugar that occurs above threshold concentrations. Afrezza closely mimics this normal response to eating, thus preventing glycation. It does so first because it becomes available via the lungs in seconds rather than tens of minutes as is the case with injection. Secondly the molecule does not require preprocessing in the liver before it can be utilized.

  • Reply to

    MNKD on the safety of Afrezza

    by nostradonuts Mar 19, 2015 10:19 PM
    musherga musherga Mar 19, 2015 11:10 PM Flag

    According to the american cancer society you are wrong:

    Smoking

    Tobacco smoking is by far the leading cause of small cell lung cancer. Most deaths due to small cell lung cancer are caused by smoking or exposure to secondhand smoke.

  • Reply to

    The movie the Jerk.

    by mcflyonthewall Mar 19, 2015 10:54 PM
    musherga musherga Mar 19, 2015 11:01 PM Flag

    Go find your special purpose.

  • Reply to

    MNKD on the safety of Afrezza

    by nostradonuts Mar 19, 2015 10:19 PM
    musherga musherga Mar 19, 2015 10:59 PM Flag

    high-concentration insulin given repeatedly into the same injection site for many decades has not generated even one report of a subcutaneous sarcoma in 90 years in tens of millions of people.

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 8:56 PM Flag

    It has been known for months stock would be delisted. If it doesn't hold I will be buying more. All the institutions that can't own pinks are already gone. Today's action is just buzzards looking for bones to pick. Look at all the covering into the close.

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 4:01 PM Flag

    bught another 5k

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 2:24 PM Flag

    to make money, silly.

  • musherga by musherga Mar 19, 2015 2:20 PM Flag

    scientific journal Basic and Applied Social Psychology has banned articles that use P-values. The problem is that the null hypothesis is ambiguous when applied to propositions that reject it.

    " P value calculations tell you only the probability of seeing a result at least as big as what you saw if there is no real effect. (In other words, the P value calculation assumes the null hypothesis is true.) A small P value — low probability of the data you measured — might mean the null hypothesis is wrong, or it might mean that you just saw some unusual data. You don’t know which."

  • musherga by musherga Mar 19, 2015 1:51 PM Flag

    new ticker symbol for the stock when it hits the OTC (pink sheets) stock exchange.

SIGA
2.050.0000(0.00%)Mar 19 4:00 PMEDT