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SIGA Technologies Inc. Message Board

musherga 63 posts  |  Last Activity: May 22, 2015 9:32 AM Member since: Apr 19, 2007
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  • I did some research. Here is my conclusion: it is important to control bs spikes. The so-called basal levels primarily inhibit gluconeogenesis, the process whereby glucose is synthesized in the liver. This mechanism provides glucose for glucose-dependent tissues while sugars are not being assimilated from food. Without insulin, blood sugar rises while fasting. But basal levels are not adequate in the face of sugar liberated during digestion of food, especially simple carbohydrates. The digestive process triggers a rapid but transient release of insulin from the pancreas that triggers uptake of glucose by tissues that can sink the excess. In some individuals up to 70 times the basal levels are secreted normally to control exogenous sugar. Excessive sugar causes glycation of protein, whereby crucial proteins are rendered inactive due to permanent binding with sugar that occurs above threshold concentrations. Afrezza closely mimics this normal response to eating, thus preventing glycation. It does so first because it becomes available via the lungs in seconds rather than tens of minutes as is the case with injection. Secondly the molecule does not require preprocessing in the liver before it can be utilized.

  • What I'm seeing in research papers is that controlling post prandial BS levels decreases the amount of basal insulin needed for control. Taken together this can produce a significant reduction in A1c. A1c is a proxy for tissue damage caused by high blood sugar. Afrezza will eventually get labeled for prediabetics and gestational diabetes IMO

  • Reply to

    Spirometry

    by pengrinc May 11, 2015 6:51 PM
    musherga musherga May 12, 2015 2:04 AM Flag

    I was a respiratory therapist for over 20 years and did hundreds if not thousands of PFT's. Not one of them was read by a pulmonologist and very few were done in a facility where any physician interpreted the tests. It's a simple procedure to get the FEV1 and there are relatively inexpensive hand held devices to do it. My opinion is that the FDA is captured by BP and the PFT label requirement is the result of competitor pressure on the board. I predict that experience will show that while some reactive bronchospasm occurs no long lasting impairment in pulmonary function will be seen with habitual use.

  • Reply to

    Todays price action only suggests 1 thing

    by delayed_gratified May 20, 2015 4:00 PM
    musherga musherga May 20, 2015 4:10 PM Flag

    bullish flag

  • Reply to

    More magical predictions

    by csmclemore Apr 20, 2015 11:47 PM
    musherga musherga Apr 21, 2015 11:16 PM Flag

    OK I've watched the arguments and read the decision (again). But I'm not totally clear on what you're saying, save for the speculation bit.

    What I see is that SC found that a type 2 agreement is operant, and therefore expectation damages *can* be applied. The problem for VC is that he already found that a lump sum is too speculative, and that specific performance is out because the lats was incomplete; missing essential terms even though economic terms were definite enough to be enforceable. Further clouding the economic terms in the LATS is evidence that there was discussion of differing economic terms after the date of the term sheet.

    Now he goes back and reverses himself saying a lump sum is supported by the record by way of expert testimony and a formula he devised to apply it. And yet the economic terms of the LATS provide no means for arriving at a lump sum owing to the temporal and probabilistic characteristics of the proposition.

    I think what you're saying is that since there's no clear way to come to a fair and accurate way of determining what the value of the license was in 2006 using either of the two methods available under a type 2 agreement, the court can only award reliance damages.

  • Reply to

    why afrezza is superior

    by musherga Mar 25, 2015 5:11 AM
    musherga musherga Mar 25, 2015 5:25 AM Flag

    It may well be the case that the spikes and subsequent damage are what cause derangement in glucose managent. Certainly reduction in the magnitude of sugar levels around mealtime will slow progression of disease. I believe under the right circumstances type 2 diabetes can be reversed. This except from the british journal of anesthesia explains why.

    Insulin normally has a tonic inhibitory control (what Schafer termed ‘chalonic’ action) on the supply of energy substrates arising mainly from metabolism in the liver, muscle and adipose tissue. Normally insulin ensures sufficient release of appropriate substrate to allow humans to cope with the eventualities of life in a highly controlled manner. Once insulin deficiency develops this control is lost, and energy substrates are over‐produced and flood the system. The metabolic consequences result from the excess of substrates not (as is often misconceived) by a lack of energy substrate getting to the tissues.

    I'm a pre-diabetic, on metformin.

  • Reply to

    MNKD on the safety of Afrezza

    by nostradonuts Mar 19, 2015 10:19 PM
    musherga musherga Mar 19, 2015 11:10 PM Flag

    According to the american cancer society you are wrong:

    Smoking

    Tobacco smoking is by far the leading cause of small cell lung cancer. Most deaths due to small cell lung cancer are caused by smoking or exposure to secondhand smoke.

  • Reply to

    SP Rise

    by twaavi Mar 4, 2015 11:21 AM
    musherga musherga Mar 9, 2015 9:53 PM Flag

    Somebody got ahold of sigas opening briefing early. Could be defense attorneys betting on their case.

  • Reply to

    Spirometer facts

    by rf1sweet May 12, 2015 3:08 PM
    musherga musherga May 13, 2015 1:01 AM Flag

    FEV1 is all the FDA said. But I understand more comprehensive measurements with a printout are needed for reimbursement of the test these days. If MD didn't care about using the PFT as a revenue generator they could use a very inexpensive device without a printer and just put the FEV1 in the progress notes. We used these flowmeters all the time to monitor asthmatics in the hospital. I see one on ebay with several washable mouthpieces for 50 bucks. The idea is to get a baseline and then monitor to make sure there's no drug-induced sensitivity which would cause wheezing/bronchospasm or inflammatory process that impairs flow. Inhalation of powders in pulmonary disease is well-established. We started using cromyln sodium powder in the early 70's. Since the insulin is synthetic I don't see why there would be any allergic issues. The TS carrier is supposedly inert. I think the concern came from AE of cough in the trials. Some coughing is experienced with other inhaled powders used to treat COPD but the benefit outweighs the side-effect and the cough usually goes away, just like cigarette smoking.

    Sentiment: Buy

  • Reply to

    Bank of America

    by my_taxes_are_2_high May 21, 2015 9:47 AM
    musherga musherga May 21, 2015 10:15 AM Flag

    means they're buying

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 8:56 PM Flag

    It has been known for months stock would be delisted. If it doesn't hold I will be buying more. All the institutions that can't own pinks are already gone. Today's action is just buzzards looking for bones to pick. Look at all the covering into the close.

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 4:01 PM Flag

    bught another 5k

  • musherga by musherga Mar 19, 2015 2:20 PM Flag

    scientific journal Basic and Applied Social Psychology has banned articles that use P-values. The problem is that the null hypothesis is ambiguous when applied to propositions that reject it.

    " P value calculations tell you only the probability of seeing a result at least as big as what you saw if there is no real effect. (In other words, the P value calculation assumes the null hypothesis is true.) A small P value — low probability of the data you measured — might mean the null hypothesis is wrong, or it might mean that you just saw some unusual data. You don’t know which."

  • Reply to

    Explain to me why people are selling

    by deej8888 Mar 19, 2015 2:21 PM
    musherga musherga Mar 19, 2015 2:24 PM Flag

    to make money, silly.

  • Reply to

    Roth Analyst...

    by bionerd51 Apr 1, 2015 5:19 AM
    musherga musherga Apr 1, 2015 9:48 AM Flag

    Chapter 1 in How to Win Friends and Influence People

    "If you want to gather honey, don't kick over the beehive"

  • Reply to

    Has the DSC decided to review this again?

    by hosaquavas Mar 31, 2015 2:38 PM
    musherga musherga Apr 1, 2015 3:04 PM Flag

    No decision in the appeal. Siga has submitted opening arguments. AFAIK next is PIP rebuttal. Bankruptcy proceedings come up again in June at NY court.

  • musherga musherga Apr 20, 2015 11:17 AM Flag

    Good find. Explains the clinical picture and the rationale for small N.

  • Reply to

    More magical predictions

    by csmclemore Apr 20, 2015 11:47 PM
    musherga musherga Apr 22, 2015 1:16 PM Flag

    The box being the paradox that there can be damages when the amount is arbitrarily chosen. This would seem to be the definition of punative.

  • Reply to

    hmmm interesting

    by itellthefuture777 May 18, 2015 12:40 AM
    musherga musherga May 18, 2015 10:51 AM Flag

    got me thinking about whether nitroglycerin could be lyophilized for inhalation.

  • musherga musherga May 22, 2015 9:32 AM Flag

    I think this also means that a catheter/well can't be used.

SIGA
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