Here's a quote on Arena's Belviq from the article: "Belviq’s national ads began in mid-April, and an executive at one of the pharmaceutical companies behind the treatment told Bloomberg News that sales increased 43 percent from the previous quarter. "
Eisai has a collaboration agreement with Biogen Idec to develop and commercialize Alzheimer's disease treatments. (see ESALY Yahoo profile to verify). I would not be surprised to see Eisai and Biogen give ARNA $75-100 million or so in a partnership on Alzheimer's disease.
You are the dumbass - look at what you just wrote. The fact is that ARNA has less than twice the shares that OREX has, and the CEO of OREX, even after his buy today, only owns less than 17% of the market cap that Jack owns. Dumbass!
Even after the OREX CEO bought 50,000 shares today, Jack still holds 7 times the number of shares in ARNA that the OREX CEO holds in OREX. Yes, it's true. Look it up! Yet there are people here that think OREX CEO is wonderful, and Jack isn't. Most retail investors are such clueless idiots. It is no wonder that most of them lose money.
He is still holding 60% of those shares. He still holds 361,039 shares. Jack had a huge part of his net worth in this company. He would be stupid to not sell some shares and diversify. I am extremely bullish on ARNA and firmly believe it will double within the next 6 months but yet I don't hold as many shares as Jack does, even though my net worth probably exceeds his.
"We have continued to see encouraging advancements in the US commercialization of BELVIQ, including a 43% quarter-over-quarter increase in estimated total prescriptions and estimated total per week prescriptions surpassing the 10,000 mark," said Jack Lief, Arena's President and Chief Executive Officer.
I just doubled my position today and had a terrible time getting shares. I watched the specialist push through block after block at a half penny above my blocks. I finally got my executions but it is obvious that some fund or institution is buying in big, and that is why they pushed it down here today. (this was not HF action) I have to believe that big money rolled out of OREX on that 47 page label and black box warning and is now coming into ARNA. Anyways, thanks for the shares to whomever sold to me and to you shorts!
This is a great benchmark against other drugs and shows that Arena will clearly become the winner.. However, this actually is too rapid of weight loss. Your heart is responsible for pumping blood and oxygen throughout your body. When you gain or lose weight, your heart must adjust to accommodate more or less body weight. Your heart is a muscle, rapid weight loss can place a lot of stress on your heart and your heart valves. As your weight changes so does your blood pressure and heart rate. You could experience irregular heart rhythms and other problems with this rapid of .weight loss. I believe their dosage needs to be adjusted downward. I caution anyone who is losing weight this rapidly to reduce dosage and slow it down.
Once you have a seizure you are much more easier subject to more - even after quitting the drug! You could not pay me enough to take that drug.
Because it contains bupropion, Contrave has a boxed warning to alert health care professionals and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.
Contrave can cause seizures and must not be used in patients who have seizure disorders. The risk of seizure is dose-related. Contrave should be discontinued and not restarted in patients who experience a seizure while being treated with Contrave.
Contrave can also raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure. The clinical significance of the increases in blood pressure and heart rate observed with Contrave treatment is unclear, especially for patients with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease, since patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Blood pressure and pulse should be measured prior to starting the drug and should be monitored at regular intervals, particularly among patients with controlled high blood pressure prior to treatment.
Would you prescribe this to an obese person with high blood pressure, which happens to be about 80% of the obese in my experience?
Yes, what you said is very true. However most doctors are not stupid enough to prescribe it and will point out the negatives to patients and prescribe BTW - I have 2 doctors in my family and am close friends with 6 other doctors, all of whom are Republicans.
A University of Bristol team, with funding from the British Heart Foundation (BHF), has now identified that a target found to be critical in the brain's regulation of body weight, is also crucially involved in the development of obesity-associated conditions. Researchers describe the mechanism behind a key molecule, known as melanocortin-4-receptor (MC4R), whose mutation or loss in both human and animal models has shown to cause severe obesity with type 2 diabetes.
While previous studies have shown that small activators of the molecule, which increase MC4R activity, have the desirable effect of reducing food intake and insulin secretion from the pancreas (important to suppress the development of type 2 diabetes), it is not clear how, at the same time, they trigger the undesirable effect of increasing blood pressure.
The team has now identified a mechanism for MC4R-mediated regulation of the activity of the autonomic nervous system to maintain appropriate blood pressure and insulin levels. The autonomic nervous system, which regulates internal organs and processes that are not under our control, is split into the parasympathetic and sympathetic nervous system, commonly exerting opposing influences on the structures they supply with nerves.
Researchers demonstrated that the activation of the MC4R inhibits parasympathetic neurons in the brain stem area of the central nervous system (CNS), while activating sympathetic neurons in the spinal cord. The team further demonstrates, in genetically-modified mouse models of human loss of MC4R function, that MC4Rs in these CNS areas are to blame for the development of obesity-induced increases in blood pressure.
80% of Obese people have problems with high blood pressure. Contrave raises blood pressure. This is a major concern and is one more reason why doctors will not prescribe it. Belviq lowers blood pressure.
Do not take Contrave, even if you are a non-responder to Belviq! Bupropion is a very dangerous drug. I have been on many forums these are just a small example of comments: Mommayiam - I had a Grand Mal Seziure while I was on this medication! I am so ticked off because now I am consider high risk of having antoher regardless of being off the meds. This medication needs to be pulled.
Posted over a year ago - Reply
Tscov - I had six months of undiagnosed DEBILITATING PAIN that was not controlled by pain medication. I also was an emotional wreck. I cried at the drop of a hat. I experienced memory loss confusion and speech problems. I was unable to care for myself. I was bedridden for months. Gradually I was able to stand and then walk for a day or two. I progressed to be able to move more. At the beginning I couldn't even hold anything due to pain and weakness. I went to a dozen doctors who were unable to diagnose my condition. Finally I was able to see a pain management doctor who had me discontinue the use of the generic wellbutrin XL. My pain has greatly subsided. The stress and pain and of course medical expenses were tremendous.Before I was diagnosed I had x-rays, ultrasounds Ct scans MRI's and an exploratory surgery. I was unable to perform daily activities and could not bend down due to the pain. I could not even wear normal clothing because of the abdominal pain. I was only able to wear wide banded sweats. It was horrific.
Posted over a year ago - Reply
Kirstenalexis - I was taking the generic anti-depressant for about two weeks and experienced memory loss, confusion, speech problems, nausea and dizziness, exaggerated emotions including unprovoked anger and had a Grand Mal Seizure a week ago today (I'm not epileptic nor have I ever had a seizure before). I was sitting up on the edge of my bed when the seizure began and fell off, injuring my shoulder and scratching my face on my hardwood floor. I've since discontinued the medication and am slowly regaining my short-term memory, but I'm unable to remember anything from when I started the drug. If there is any information about a class action lawsuit, I would like to know about it. More people need to be aware of the possible side effects as they seem to be fairly common and serious.
Posted over a year ago - Reply
Ryansgranny - I would like to know if anyone took it and continued to gain weight. I have put on 30 pounds and my blood sugar is crazy. The doctor told me that taking stuff like that can put on weight but I never imagined that it would do this to me.
Posted over a year ago - Reply
Duba - Well reading all this is some what's surprising about three years ago my Dr. took me off of Celexa and put me on Wellbutrin because she said it would help you lose weight and it would help me with the sexual side effects that I was having with the Celexa. During the time of changing over I was taking the Celexa and the Wellbutrin at the same time to the Dr.'s orders I wound up having a seizure at the wheel and going through a red light and hit someone. When the paramedics arrived they were calling on a medevac helicopter to take me into the hospital. So they put me back on the Celexa only.
There is a big difference between depression and thoughts, and actual attempts at suicide like Cotrave components caused. That's why Contrave gets Black Box Warning and Belviq gets no adverse warning.
Yes, it will be a huge win for Arena. Like I said, after Takeda has convinced doctors that they should be prescribing weight loss pills, Arena sales reps will come in and show all the negatives in that approval letter and the Black Box Warning and the safety profile of Belviq and the doctors will prescribe Belviq. This is a huge, huge win for ARNA!