agreed. they are setting it up for another run to 16 to write more call options with October strikes
it is so obvious hy buy the short term calls. if you are going to buy calls go for leaps jan 2016 pick any strike.
knwo if the hedgies would grow a pare they would drop it $12.
is IO going up and SI down or are both moving up?
Francesco congrats on the Os.
Raymond - there is always next year, but after that they move to Montreal.
ys and lots of it. funny thing i sleep well at night. no cold sweats. zilch.
PFS benefit and less toxic. the less toxic wil not change from Piii results. all it eeds to do is hold onto PFS benefit. arugably if the PFS is the same they have a c ase for approval based on less toxic.
yes I know the CEO is das dirty as they come. it does not chnage the science. sometimes a good horse wins even with a crooked jockey.
realioty is the pps is a play thing for the hedge funds with such a small public foat. not a big fan of the CEO but he is honest with a track record.
yes corporate america is not only corrupt but broken.
but the question at hand is will aldox be approved in 2nd line STS? if so, then money to be made from this share price.
he cannot short it.
they need to cash more premiums in October. September's haul was $1 million +. easy money
low retail float enables the game to be played and replayed.
nice if they would play the game in the $20's post React results.
we collectively need to become more agressive. propose a new set of directors at the next annual meeting. see if the IO will get behind this move, if so it will be the start of real change.
is there a securities lawyer on the BOARD?
they need to find a large investor to manipulate the share price to get it done
ceo is a distraction - focus on PIII STS trial in 2nd lne setting - if it meets PFS target it gets approved.
they have the cash to complete this study. SCLC also seems promising. GBM is a long shot with long odds, but like a good horse race the pay off is huge
tough to do an offerring at $1 of any size.
will let you know what they say. literature search is all over the place. if HSA unbound to dox does not cross the BBB in humans then the glio study is likley a waste of time. If it does then results could be interesting. Mouse model not the same as humans. its not about uptake and release by the cancer, that is the easy part its about croosing bbb, mouse barin is less "tight", more leaky than human brain.
Nanoparticles made of human serum albumin (HSA) and modified with apolipoproteins have previously been shown to transport drugs, which normally do not enter the brain, across the blood-brain barrier (BBB). However the precise mechanism by which nanoparticles with different apolipoproteins on their surface can target to the brain, as yet, has not been totally elucidated. In the present study, HSA nanoparticles with covalently bound apolipoprotein A-I (Apo A-I) as a targetor for brain capillary endothelial cells were injected intravenously into SV 129 mice and Wistar rats. The rodents were sacrificed after 15 or 30 min, and their brains were examined by transmission electron microscopy. Apo A-I nanoparticles could be found inside the endothelial cells of brain capillaries as well as within parenchymal brain tissue of both, mice and rats, whereas control particles without Apo A-I on their surface did not cross the BBB during our experiments. The maintenance of tight junction integrity and barrier function during treatment with nanoparticles was demonstrated by perfusion with a fixative containing lanthanum nitrate as an electron dense marker for the permeability of tight junctions.
you play for nickles and dimes, i could not be bothered with loose change.
i bet large on 5 - 10 baggers, with measured downside risk.
time will tell who is right.
my other biotech holding is cldx. same approach have been in it since the $3s.
lost sme bucks on binary bets, but thats ok, i was bored.
cytr is not a binary bet, its a buy and hold.
i will hold for aldox approval in 2nd line STS based on PFS and low cardio.
the rest does not fuss me. yes the ceo is a bloW hard. yes he scammed GALE shareholders by pumping and dumping. but at cytr he pumped, but i did noT ee the DUMP, DID YOU?
my take is that aldox will cross BBB. as for safety and efficacy its a complete unknown. mouse model gives me no comfort. at $3 no downside to this study with a huge upside potential if they get lucky.