Considering the previous methods for assessing AD included autopsy and brain studies after death and considering A2-73 is a potential breakthrough in treatment then Cogstate verification and validation as a effective measurement tool of treatment efficacy this potential collaborative reporting is great to see. The accuracy and credibility of the Cogstate methods may lead the way in reporting some trial findings.
If the information is packaged as we expect w/bullet proof test methods and trials data/results then $25 is easily doable. This has never been done before.
Just in case we need a context for this investment. copied from Yahoo...
Common Symptoms of Alzheimer's, by Stage
Problems retrieving words or names
Cannot recall details from personal history
Unaware of surroundings
Trouble retaining new information Disoriented in terms of place and time
Major personality changes
Forgetting where objects have been placed
Difficulty choosing proper clothing for the season
Full-time care is required
Changes in mood
May wander or become lost
Loss of ability to walk, sit, and eventually swallow
May experience behavioral and personality changes
Increasing difficulty communicating
Withdrawal from social situations
Vulnerable to infections
Source: Pharmacy Times
These stages are general descriptions, as each individual with Alzheimer's experiences it in a unique way. Mental, physical and functional phases often overlap, the time in each stage varies widely from patient to patient and not every patient experiences all Alzheimer's symptoms.
Memory problems and changes in behavior and thinking are common as people age, so tests are needed to rule out other causes of symptoms that appear to be related to Alzheimer's. Some conditions (such as stroke, tumor, Parkinson's disease, sleep disturbances, adverse effects of medication, infections or non-Alzheimer's dementia) can mimic the symptoms of Alzheimer's disease, but many of these conditions are treatable and possibly reversible.
The amount of time an individual can live with Alzheimer's can range from three or four years, if older than 80 years when given a diagnosis, to as long as 10 years or more if younger than 80 years. Alzheimer's can only be definitively diagnosed after death, however, by linking symptoms with examination of brain tissue in an autopsy.
Stage 1: Mild/Early (Lasts 2 to 4 Years)
Alzheimer's disease begins slowly and initially involves the parts of the brain that control thought, memory and language. In the very early stag
"Alzheimer's can only be definitively diagnosed after death, however, by linking symptoms with examination of brain tissue in an autopsy"....Getting analysis right is critical. IMO, the stakes could not be higher.
I have an idea for a new drug. Small pill which you take when you need to lapse into a coma for a day(s) or so. No side issues. Take it, sit at your desk as usual, all functions normal...when it wears off you awake to whatever......as good as new. Question, what would such a new drug be worth? Ideal for such days as today.
Well, there it is then....we already have a name for this new drug...we will call it the .."So What".. pill.
And, for some we could sell in mass quantities...perfect.
DIGITAL BIOMARKERS CONFERENCE AGENDA
12:15 p.m. Lunch All 60 minutes
1:15 p.m. CogState Paul Maruff, PhD
Chief Science Officer, CogState, Ltd. 20 minutes
To the extent that AVXL relies on COG results to verify A2-73 results(claims) then peer reviewed validation of the method at this conference is relevant and positive.
Exactly correct attitude as we suspected. BTW, this has never been done before. At some point someone will have to declare victory.
" so that there can be no doubt as to the cause-effect relationship"
Considering the critical nature of this analysis, I am confident every precaution is being used. I watched Dr M. video (see mouse story) this week and he looked about as loose as he could be. Many good observations made here about CAG and the scope of their operations. My read of the tea leaves is, they have the analysis done, the results are strong. They understand that the BP/scammers, etc will attack whatever they say. I am amazed there have been no signs of leakage. I'm dying over here.