I realize that is is hard to hear the negatives and challenges facing a drug/company when you believe so heavily in it. I get it but instead of everyone talking about manipulation from hedge funds, big pharma doesnt want it to work, SEC should investigate Adam F, where the stock price is going to be, etc... You should be looking at similar past trials and think about some of the reasons why the drug may not work after all. Just sayin, but it is your money. By the way I am not short this stock and definitely not long
2 reasons why they are allowing it.
1)immunotherapy has been proven to be safe
2)because it uses the patients own cells
If this was a chemo drug there would be no chance in hell they would allow it. They did not allow compassionate use because it was proven effective. It was allowed for the above reasons only.
You may want to do a little research of the difficulties on treating this disease
1) GBM has been difficult to treat with immunotherapy because of their immunosuppressive nature and the immune privilege provided by the BBB. The physical isolation of brain by the BBB, low or absent expression of human leukocyte antigens (HLA) on brain cells can suggest that the requirements for initiation of immune responses within the brain are significantly more stringent. Collectively, these observations led many to accept the idea that immune surveillance does not occur within the brain.
2) Gliomas are genetically unstable, heterogeneous and highly infiltrative; all characteristics that lend glioma cells superior advantages in resisting therapies. One interaction required for efficient effector cell lysis of tumor cells is effector binding to tumor cell surfaces. GBM tumor cells have developed strategies to prevent their adhesion by immune effector cells. The same mechanisms in place that protect gliomas from rejection by the host immune system may also impede the ability of brain tumor immunotherapies to eradicate the tumors or to suppress their growth.
Personally I am looking forward to a GBM drug that can block a cloaking mechanism used by cancer cells to hide from a patient's immune system. These drugs have shown great results. Dendritic immunotherapy with a de-cloaking mechanism may just have chance however it still would be greatly challenged due to some of the reasons above. Most wont believe this by I truly want NWBO to succeed for the patients sake however I believe there are just too many challenges for this drug to work. If you want to place a bet on their success go for it, I just wouldn't bet the bank on it.
Shorting stocks is an important part of the market and can make one a lot of money if done right so nothing against that. SSH is not one that I would risk shorting however as if they would receive a buyout offer it would be a minimum of 3-4X todays market cap. That would cost shorts their shorts and would be hard to recover from. HTWR received a 300 million buyout offer from THOR and one could easily argue the potential for SSH is far greater. So if you want to short SSH more power to you, just not one of the smarter moves in my opinion. Personally I feel it results of the current trial show similar efficacy to previous results than the trial will get stopped early. Obviously that is down the road aways but again one would see huge jump in the PPS and shorts would be screwed.
Shorts better hope for some bad news or they will have one heck of a time trying to find shares to cover. Nice to see she is holding strong so far on this red day.
Hah you guys are too funny. Thanks for the laugh.
I feel sorry for those individuals like yourself that are paid to promote scam companies.
You NWBO cult groupies are hilarious. Just to let help you out.
1)Big Pharma is not threatened by NWBO. They are using extremely old technology that big pharma has already tried knows doesn't work. They are interested in PD1/PDL1 inhibitors which actually do work for solid tumors and many other indications
2) Adam F. does not write articles for his friends that are short NWBO. He writes about NWBO because the company is very clearly a scam and wants the world to know.
3) MM are not taking down the stock or taking out stops. They could care less about NWBO
4) Being added to Russel index will not shoot this to the moon. Take a look at some previous bio stocks that were added in previous years. Did almost nothing to affect the share price.
All of these conspiracy theories are hysterical. True sign of a cult stock indeed. Ok now, lets see those thumbs down, I want to see at least 20 of them.
I am not long nor short NWBO. I would probably take out a short position if Fidelity had some shares to short but they dont. My main purpose it to inform new shareholders what kind of company they are invested it. It makes me upset that Linda is purposely putting out lie after lie to fool shareholders and for her financial gain. She will unload her shares when the timing is right sort of like GALE leadership did after their pumping campaign. I know, I know, you all are big boys and did you DD, etc, etc....
That is because the article was too large. Here is the rest of it for you.
Our view of NWBO management would be greatly improved if NWBO would hire a CFO and separate the financial and accounting responsibilities away from the CEO.
Our mission at Red Acre Investments is to provide actionable analysis on binary events, special situations, and mispriced securities. To take advantage of our analysis and Get Ahead of the Curve, Sign-Up for the Free Red Acre Review Today
Suppose for example you are analyzing a public company whose CEO has, earlier in their career, held a high post at a previous public company that turned out to be a colossal scam. Next, suppose that that CEO consolidated all fiscal responsibility in their company by also being the CFO and principal accounting officer. Now suppose that that same CEO had a separate company that provided critical services to the public company in question, and, due to the CEO's role as CFO was able to negotiate a deal where the related company was partially paid in stock at prices well below what shareholders would pay on the open market. Next suppose that the company in question repeatedly made misleading and inappropriate comparisons between very early stage data from their product compared to the standard of care - both in their SEC filings as well as in statements to the press. Now suppose that a competitor whose therapy, though a bit different, nevertheless used the same basic therapeutic approach and recently showed disappointing results suggesting that early trial results were successful due to cherry-picked patients. Finally suppose this company has delayed and missed timelines on trial enrollment as well as announcements of results. All of these factors weigh in on the skepticism side of equation. On the hope side are a very small single-center open-label trial showing promising results but which may be explained by cherry-picking. And a recent move by a European country to allow it's citizens who have only months left to live to try the company's experimental therapy on a compassionate, last-resort basis. Of course, this is not a theoretical situation, this is exactly the situation that NWBO is in right now.
Without a doubt, should DCVax-L work, investors long NWBO will do well. however, based on the situation as we see it, we cannot find the conviction to hold the stock long term. Our view is that DCVax-L will ultimately fail.
Very well written and you are exactly right. Lindas job at Enron was persuading underdeveloped countries that they needed Enron's Electricity/Power. Of course she had to lie to the leaders of the country and our government to get it done. This job is no different and suits her strengths perfectly. She is "selling the dream" to poor retail investors even though she knows DVAX does not have a chance.
Rumors of corruption arose in 1995 when Enron executive Linda Powers told a subcommittee of the U.S. House that $20 million had been spent "educating" Indians. Indian politicians and news media alleged the money was used to buy political influence.
"They bought over all the political parties … who were opposing them," charged Pradyumna Kaul, a management consultant whose Anti-Enron Front is waging a separate court battle to have the Enron contract voided.
type "enron and the dabhol power plant linda powers" into google search engine. You may want to know the person running this company. People do not change. She lied for financial gain with Enron and you think she will not do the same here?
Oh I see, so if you are not convicted then you did nothing wrong. So your saying OJ Simpson was innocent then?
Yes she will make money however it will be at the expense of NWBO investors. NWBO stockholders will lose their ass.
It is not a mis-statement at all. It is "oh crap we are busted lets stop the lies and correct our statement before the *$#* really hits the fan" statement.