share your feelings, have been in ttnp for quite some years, suffered through iloperidone and other candidates that never materialized, but now I am hoping for a well deserved and long awaited for reward.
btw, what happened to my long time friend windsurfar, he more than a decade ago pointed out that implants would some day be the most valuable titan product.
AbbVie ($ABBV) has expanded its cystic fibrosis deal with Galapagos ($GLPG), positioning the Belgian biotech to pocket $250 million (#$%$218 million) more than under the original agreement if it hits all of its milestones. The dialed-up deal follows a shift in focus from double to triple combinations of cystic fibrosis drugs, an evolution that has increased the early-phase workload Galapagos is shouldering.
Galapagos is aiming to start testing its triple combination in humans next year.
Orkambi: Investors can't seem to reach a consensus trajectory for the drug's early launch, except that it's been slower than everyone first believed it would be.
The sell side and the buy side already have cut Orkambi sales estimates this year. The worry now is that another downward revision might be necessary if Vertex's first-quarter earnings coming later this month come up short.
q, VRTX pipeline certainly would warrant a higher share price, but fact is, VRTX has lost much more value than its peers. So there must be specific reasons. In my opinion it is the lack of forecast for Orkambi sales. Management indicates that in real life application Orkambi might not be as good as expected. VRTX needs to give reliable forecasts for Orkambi, if they do not provide that guidance the sp will continue to decline.
VRTX refusal to issue forecasts for sales of Orkambi has contributed significantly to investors uncertainty. Highlighting potential drop-out rates for patients on Orkambi has confused investors, too. Next CC with quarterly sales of Orkambi in April may bring some clarity. Until then I expect more volatility in sp.
is it really a worthwhile effort to highlight potential problems of the lead product? VRTX ought to focus on the big picture: sales potential iva and orkambi, VX-661, second gen. compounds, non cf pipeline etc.
Right now VRTX keeps providing the impression that it is facing problems with orkambi. The sp reacts accordingly.
why is VRTX participating in such conferences when they have nothing to talk about, but potential drop-out rates for orcambi? Such discussions will not enhance investors trust in the company.
I agree that a take-over is highly unlikely. Guess, all of us don't understand why VRTX has lost one-third of its value in the last few months. There have been no negative setbacks that might explain the drastic loss in value.