"Do We Really Need to Continue Pharmacotherapy for Opioid Use Disorder (OUD) Indefinitely? “It is unclear whether pharmacotherapy for opioid use disorder (OUD) should be continued for short or long-term. Before the introduction of buprenorphine, methadone was the primary pharmacotherapy for OUD in the United states.
Because of its specific pharmacokinetic properties methadone was recommended for long-term use with some justification. The introduction of buprenorphine, however, has altered the treatment protocols. although Buprenorphine adverse effects and withdrawal symptoms are milder than for methadone, they are not
negligible. Therefore, the indefinite prescription of buprenorphine is only justified when there is a significant benefit. studies that have compared short and longterm treatment with buprenorphine protocols do not show a significant benefit of long-term treatment over relatively short-term (few months) treatment protocols. Obviously, ultra short-term treatment lasting a few days has very little or no benefit. Protocols that use buprenorphine, for 3 to 9 months, are as effective as long-term treatment, for years to lifetime, without the financial and medical consequences of the long-term treatment.”
no quest, I don't care who sells or holds. it is your money, lose it any way you choose. I do care about the next round of gullible traders that only see the "jonny-pump" posts and fake articles about gold standards and such. I also care about the lack of science and facts, and how the promotion of theory based recovery is in reality destroying lives of truly innocent people, and not the #$%$ attempting to profit from their misfortune. heroin addiction and Rx addiction are not the same thing, yet the trial didn't really differentiate the two, did it? oh, the barrels will be rolling when they try to dance around the definition of abstinence and what the trial's end results actually mean. no one in their right mind will approve or prescribe a 6 month implant to prolong detoxing. it simply does not make sense, just ask a real doctor, not some phony treatment shrink trying to validate his profession.
I'm referring to buprenorphine with or without naltrexone. The claims of superiority have nothing to do with actually curing addiction. There are intentionally no "real" long term studies, because the majority of addicts who are hoodwinked into taking another addictive drug like this almost always relapse in the end. Titan's study consisted of so-called stabilized addicts. They had 90 days of a lower dose of subutex prior to getting the implant, which as you know, has a higher plasma concentration of the drug found.
c'mon jonny-pump, even you can figure this one out. will addicts be showing up that ER to get their arm amputated due to gangrene?
in fact the failure rate is ridiculous, unless you consider continued addiction to a narcotic 100 times more powerful than morphine a success. the implant does not cure or help addicts. daily drinking and alcoholism were the norm back in the 50's and 60's. imagine if they just switched the addicts to hard liquor and claimed success. that is what they are doing to pill popping addicts hooked on codeine and percs. this stupid drug is ruining more lives than it supposedly saves.
"Suboxone does have some value in the actual temporary detox process, where it can be administered to curb the potential discomfort of opiate withdrawal. We don’t deny this. However, suboxone has withdrawal potential of its own, so it must be very carefully limited and monitored with the goal of being tapered completely just like the opiates themselves. Used in this manner, it is a tool that has a very limited scope in its benefits, but those benefits exist.
However, that is not where the suboxone story ends. The replacement drug therapy lie is that you will NEED a continued regimen for life or you are certain to return to problematic opiate use. As is the case with all the recovery society half-truths they miss the all-important point with the replacement drug model, and that is why the person likes to get high in the first place! Because this portion of the issue is ignored completely and goes unanswered, the person eventually stops their suboxone treatments (because suboxone doesn’t get you as high as heroin in comparable respective dosages) and returns to opiate use and is seen by recovery society members as a recovery failure. As a whole, suboxone replacement therapy it is a remarkably ineffective and damaging method to deal with problematic opiate use because the reasons for one’s use are never addressed in this model."
At Maryland Addiction Recovery Center, we do not believe in a “harm reduction model” of treatment. We do not believe in a long-term “maintenance” model of treatment. We DO believe that Suboxone is a useful medication to aid someone in getting off opiates altogether and we DO use it at MARC utilizing a detox protocol. Some of us are former opiate and heroin addicts now in long-term recovery. Some of us have dealt firsthand with a Suboxone maintenance model and have dealt with the issues of getting off Suboxone. We believe that there is a better way, that actual recovery exists, that you can be free and clear and not need to be medication dependent in this way. We believe that no opiate addict is a lost cause and we don’t believe in selling an addict or their family short by offering an easier, softer way. We believe in actual treatment, comprehensive addiction treatment that supports long-term, sustainable recovery. We believe that any addict can recover
"These patients were attempting to overcome addictions to powerful narcotics like heroin and OxyContin and many doctors offered Suboxone as the answer to these patients. However, regardless of the justifications or rationalizations from many within the medical and addiction treatment field, the basic premise of a Suboxone maintenance program is trading one illegal drug for a legal drug. It is saying “take this pill and you’ll be okay” or “take this pill and it will take care of your addiction.” Basically, patientss going into a doctor’s office to find away to “overcome their addiction” are years later finding themselves still physically dependent and addicted to a substance. Suboxone keeps opiate withdrawal symptoms at bay, but does not offer any actual treatment and clearly does not offer a solution for overcoming addiction. Take the Suboxone supply away from a person on a Suboxone maintenance program and there is little doubt that they will turn to heroin or OxyContin or another form of opiate once withdrawal symptoms begin. This is not the patients fault- they were sold a faulty bill of goods by many of those people prescribing Suboxone."
Don't let common sense cloud your judgment. A 6 month implant for the most unpredictable class of people is beyond irresponsible. What will happen when one doesn't come back? How long before the implant turns TOXIC? If you do not know the answer, you have not done your dd.
what does that have to do with a 6 month implant? there already are cheaper and more effective drugs and treatment options. perpetual drug addiction maintenance is a scam. there is no use for the implant, no one will be lining up for it, and no doctors are going to be pushing it. it is a failed concept with disastrous consequences for the patient/client/victim.
I do not know any such thing, and neither do you. It is not highly likely to go up 30% for any reason, approval or not.
The only news coming will be delays followed by lower shareholder equity. Braeburn is part of a venture capital group. They are not "too invested" to buy Titan for any premium. They already own what little value there is, never mind buying Titan's debt. I'm sure Apple Tree can always use the write-off.
unfortunately, you are living proof that treatment doesn't work. my advice to you is to buy more ttnp. take a pay day loan, second mortgage, or borrow it from your family, but buy as much as you can and never look back.
Sentiment: Strong Sell
the fact that they didn't cut the divi and insiders continue to buy is a good sign. why are they hiring an acquisition specialist? i didn't see anything in the filings, but I'm sure there will be a mention of it at the cc.
ticker exel has been most kind to me this year. I sold out of it a month ago, and started to take another/new position in it beginning today. check it out for an interesting trade idea for the next 6 months.