correct -the republicans have done everything in their power to have Obama fail just for their reelection
yet you probably believe in a employer based healthcare either way the republicans are against a employer based healthcare, pensions, and unions. So then we are forced to have our own healthcare (anyway), 401k and fight for our own rights against a system the capitalist corporations own backed by the republican party.
Although ibrutinib has been found to be a potent inhibitor of BTK and downstream signaling of the BCR pathway, data have also been generated that suggest that ibrutinib can inhibit other important pathways. Studies have shown that ibrutinib is able to inhibit activation and function of human basophils. BTK is also able to inhibit the secretion of tumor necrosis factor-α, IL-1β, and IL-6 from primary monocytes, particularly those present in autoimmune arthritis.6 Furthermore, BTK inhibition inhibits the release of histamine, tumor necrosis factor-α, IL-8, and monocyte chemoattractant protein-1 from activated human mast cells. In B-cell malignancies such as multiple myeloma, BTK inhibition also inhibits multiple cytokines and chemokines secreted by autoclasts and bone marrow stromal cells. Furthermore, BTK inhibition with ibrutinib also decreased stromal cell-derived factor-1–induced migration of multiple myeloma cells and down-regulated macrophage-inflammatory protein-1α in multiple myeloma cells.7
As shown in the article by Dubovsky et al,1 the small molecule ibrutinib, which inhibits BTK signaling and suppresses malignant B-cell growth, also inhibits ITK and thereby skews the development of T cells toward a Th1 phenotype. The authors show in neoplastic mouse models, including a mouse model of CLL and parasitic infection models using Leishmania major and infectious disease models using Listeria monocytogenes, that ibrutinib is able to specifically promote Th1 responses, resulting in improved outcomes. These findings strongly suggest a pleiotropic mechanism of action of ibrutinib. Not only is there a specific inhibition and downregulation of BCR signaling directly inhibiting the proliferation and survival of the malignant B cell, there is also inhibition of ITK with a dramatic change in the tumor microenvironment promoting a Th1 response that promotes immune regulation that inhibits malignant cell growth (see figure). The findings of this study suggest that ibrutinib may be successful in the treatment of a variety of diseases, particularly B-cell malignancies, because of its effect not only on the malignant B cell and on the immune response and tumor microenvironment.
blaming all wrong with the economy to Obama care is just wrong. The 40 hr work week has been decimated by the republicans/corporations the past decade.
wmd is poisonous gas? Geez that's a no brainer who doesn't have poisonous gas - -I thought we bombed that- - look it up - -we bombed the poisonous gas bunkers - -its a restricted area due to high level of poison
W r u talking about - -that era was a service related field including housing/construction jobs and waiters - the so called corp were slimming down and sending everything to china/mexico while improving white collar pay